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    ARHGAP26 Rho GTPase activating protein 26 [ Homo sapiens (human) ]

    Gene ID: 23092, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ARHGAP26provided by HGNC
    Official Full Name
    Rho GTPase activating protein 26provided by HGNC
    Primary source
    HGNC:HGNC:17073
    See related
    Ensembl:ENSG00000145819 MIM:605370; AllianceGenome:HGNC:17073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRAF; GRAF1; OPHN1L; OPHN1L1
    Summary
    Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
    Expression
    Ubiquitous expression in brain (RPKM 7.0), gall bladder (RPKM 4.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q31.3
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (142770377..143229011)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143301685..143760366)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (142149942..142608576)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene FGF1 promoter C Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:142024170-142025369 Neighboring gene Sharpr-MPRA regulatory region 3450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142039508-142040008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142040009-142040509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047003-142047511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047512-142048019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142049247-142049746 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142052360-142052880 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:142064129-142064998 Neighboring gene fibroblast growth factor 1 Neighboring gene FGF1 promoter B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142150581-142151416 Neighboring gene long intergenic non-protein coding RNA 1844 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142176991-142177492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16477 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142242364-142242980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142242981-142243597 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142243598-142244214 Neighboring gene Sharpr-MPRA regulatory region 7053 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142275426-142276332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:142296188-142296688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:142296689-142297189 Neighboring gene uncharacterized LOC107986457 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142362256-142363097 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142361413-142362255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23321 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:142388320-142389519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23324 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142416478-142417238 Neighboring gene uncharacterized LOC124901097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23326 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:142469655-142470246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142472885-142473646 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:142473647-142474407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23327 Neighboring gene uncharacterized LOC124901098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23329 Neighboring gene ARHGAP26 intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142586801-142587300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142593978-142594526 Neighboring gene uncharacterized LOC124901099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142594527-142595075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23335 Neighboring gene uncharacterized LOC124901100 Neighboring gene nuclear receptor subfamily 3 group C member 1 Neighboring gene ribosomal protein L7 pseudogene 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease. Wang K, et al. J Mol Neurosci, 2022 May. PMID 35171450
    2. The role of GTPase-activating protein ARHGAP26 in human cancers. Zhang L, et al. Mol Cell Biochem, 2022 Jan. PMID 34716859, Free PMC Article
    3. Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells. Wangxia LV, et al. Saudi J Gastroenterol, 2019 Mar-Apr. PMID 30719998, Free PMC Article
    4. Hypoxia-induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA-ROCK-PTEN pathway. Li M, et al. J Cell Biochem, 2019 Jun. PMID 30592323
    5. Involvement of Rho GAP GRAF1 in maintenance of epithelial phenotype. Regev M, et al. Cell Adh Migr, 2017 Jul 4. PMID 27588930, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
      Title: GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
    2. CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.
      Title: CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.
    3. Missense Variants in <i>GFRA1</i> and <i>NPNT</i> Are Associated with Congenital Anomalies of the Kidney and Urinary Tract.
      Title: Missense Variants in GFRA1 and NPNT Are Associated with Congenital Anomalies of the Kidney and Urinary Tract.
    4. Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease.
      Title: Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease.
    5. The role of GTPase-activating protein ARHGAP26 in human cancers.
      Title: The role of GTPase-activating protein ARHGAP26 in human cancers.
    6. Data indicate that hypoxia-induced Rho GTPase activating protein 26 (ARHGAP26) deficiency inhibits ductus arteriosus smooth muscle cells (DASMCs) proliferation and migration through activating the RhoA-ROCK-PTEN pathway.
      Title: Hypoxia-induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA-ROCK-PTEN pathway.
    7. ARHGAP26 upregulation in SKOV3 cells significantly inhibited SMURF1 upregulation-induced cell migration and invasion. Overall, SMURF1-mediated ubiquitination of ARHGAP26 may promote invasion and migration of ovarian cancer cells via the beta-catenin pathway.
      Title: SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.
    8. High ARHGAP26 expression is associated with adenomyosis.
      Title: RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
    9. This study showed that the circARHGAP26 is overexpressed and its downregulation inhibits cell proliferation and promotes cells apoptosis in GC cells.
      Title: Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells.
    10. GRAF1 plays a role in the maintenance of normal epithelial phenotype and its depletion leads to an epithelial-mesenchymal transition-like process that might be involved in neoplastic transformation.
      Title: Involvement of Rho GAP GRAF1 in maintenance of epithelial phenotype.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Juvenile myelomonocytic leukemia
    MedGen: C0349639 OMIM: 607785 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42530, KIAA0621

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 26
    Names
    GTPase regulator associated with focal adhesion kinase pp125(FAK)
    oligophrenin-1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016711.2 RefSeqGene

      Range
      5008..463642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1127

    mRNA and Protein(s)

    1. NM_001135608.3 → NP_001129080.1  rho GTPase-activating protein 26 isoform b

      See identical proteins and their annotated locations for NP_001129080.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC004782, AC008533, AC012630, AI888512, BC068555, BX342449
      Consensus CDS
      CCDS47297.1
      UniProtKB/TrEMBL
      A0A0S2Z536, A0A2X0SSF1
      Related
      ENSP00000495131.1, ENST00000645722.2
      Conserved Domains (4) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:704 → 759
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

    2. NM_001349547.2 → NP_001336476.1  rho GTPase-activating protein 26 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC004782, AC005348, AC008533, AC012630
      Consensus CDS
      CCDS87332.1
      UniProtKB/TrEMBL
      A0A0S2Z508, A0A2R8YGB3
      Related
      ENSP00000495827.1, ENST00000642734.1
      Conserved Domains (4) summary
      cd12064
      Location:631 → 686
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:328 → 527
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_015071.6 → NP_055886.1  rho GTPase-activating protein 26 isoform a

      See identical proteins and their annotated locations for NP_055886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC004782, AC008533, AC012630, AF141884, AI888512, BC068555, BX342449
      Consensus CDS
      CCDS4277.1
      UniProtKB/Swiss-Prot
      O75117, Q5D035, Q9BYS6, Q9BYS7, Q9UJ00, Q9UNA1
      UniProtKB/TrEMBL
      A0A2X0SSF1
      Related
      ENSP00000274498.4, ENST00000274498.9
      Conserved Domains (5) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:759 → 814
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 364
      PH; PH domain

    RNA

    1. NR_146198.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004782, AC005348, AC008533, AC012630

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      142770377..143229011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268402.5 → XP_005268459.1  rho GTPase-activating protein 26 isoform X23

      See identical proteins and their annotated locations for XP_005268459.1

      UniProtKB/TrEMBL
      A0A0S2Z508
      Conserved Domains (5) summary
      cd07636
      Location:19 → 225
      BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
      cd12064
      Location:667 → 722
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:364 → 563
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 371
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:267 → 364
      PH; PH domain

    2. XM_047416970.1 → XP_047272926.1  rho GTPase-activating protein 26 isoform X5

    3. XM_047416985.1 → XP_047272941.1  rho GTPase-activating protein 26 isoform X20

    4. XM_047416991.1 → XP_047272947.1  rho GTPase-activating protein 26 isoform X30

    5. XM_047416993.1 → XP_047272949.1  rho GTPase-activating protein 26 isoform X32

    6. XM_005268398.6 → XP_005268455.2  rho GTPase-activating protein 26 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SSF1
      Conserved Domains (4) summary
      cd12064
      Location:723 → 778
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:328 → 527
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_017009248.3 → XP_016864737.2  rho GTPase-activating protein 26 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SSF1
      Conserved Domains (4) summary
      cd12064
      Location:678 → 733
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:328 → 527
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    8. XM_005268399.6 → XP_005268456.2  rho GTPase-activating protein 26 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SSF1
      Conserved Domains (4) summary
      cd12064
      Location:668 → 723
      SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
      cd04374
      Location:328 → 527
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_047416976.1 → XP_047272932.1  rho GTPase-activating protein 26 isoform X13

    10. XM_047416981.1 → XP_047272937.1  rho GTPase-activating protein 26 isoform X18

    11. XM_047416969.1 → XP_047272925.1  rho GTPase-activating protein 26 isoform X4

    12. XM_047416966.1 → XP_047272922.1  rho GTPase-activating protein 26 isoform X1

    13. XM_047416967.1 → XP_047272923.1  rho GTPase-activating protein 26 isoform X2

    14. XM_047416971.1 → XP_047272927.1  rho GTPase-activating protein 26 isoform X6

    15. XM_047416972.1 → XP_047272928.1  rho GTPase-activating protein 26 isoform X8

    16. XM_047416973.1 → XP_047272929.1  rho GTPase-activating protein 26 isoform X9

    17. XM_047416979.1 → XP_047272935.1  rho GTPase-activating protein 26 isoform X16

    18. XM_047416978.1 → XP_047272934.1  rho GTPase-activating protein 26 isoform X15

    19. XM_017009250.3 → XP_016864739.2  rho GTPase-activating protein 26 isoform X22

      UniProtKB/TrEMBL
      A0A0S2Z508
      Conserved Domains (3) summary
      cd04374
      Location:328 → 527
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    20. XM_047416986.1 → XP_047272942.1  rho GTPase-activating protein 26 isoform X21

    21. XM_047416989.1 → XP_047272945.1  rho GTPase-activating protein 26 isoform X29

    22. XM_011537611.4 → XP_011535913.2  rho GTPase-activating protein 26 isoform X28

      Conserved Domains (3) summary
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:328 → 484
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    23. XM_006714774.5 → XP_006714837.2  rho GTPase-activating protein 26 isoform X26

      Conserved Domains (3) summary
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:328 → 479
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    24. XM_011537610.4 → XP_011535912.2  rho GTPase-activating protein 26 isoform X27

      Conserved Domains (3) summary
      cd01249
      Location:231 → 335
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:328 → 479
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:15 → 189
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    25. XM_047416983.1 → XP_047272939.1  rho GTPase-activating protein 26 isoform X20

    26. XM_047416977.1 → XP_047272933.1  rho GTPase-activating protein 26 isoform X14

    27. XM_047416987.1 → XP_047272943.1  rho GTPase-activating protein 26 isoform X24

    28. XM_047416984.1 → XP_047272940.1  rho GTPase-activating protein 26 isoform X20

    29. XM_047416990.1 → XP_047272946.1  rho GTPase-activating protein 26 isoform X20

    30. XM_047416974.1 → XP_047272930.1  rho GTPase-activating protein 26 isoform X11

    31. XM_047416975.1 → XP_047272931.1  rho GTPase-activating protein 26 isoform X12

    32. XM_047416980.1 → XP_047272936.1  rho GTPase-activating protein 26 isoform X17

    33. XM_047416988.1 → XP_047272944.1  rho GTPase-activating protein 26 isoform X25

    34. XM_047416982.1 → XP_047272938.1  rho GTPase-activating protein 26 isoform X19

    35. XM_047416992.1 → XP_047272948.1  rho GTPase-activating protein 26 isoform X31

    RNA

    1. XR_007058592.1 RNA Sequence

    2. XR_007058593.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      143301685..143760366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352138.1 → XP_054208113.1  rho GTPase-activating protein 26 isoform X23

    2. XM_054352119.1 → XP_054208094.1  rho GTPase-activating protein 26 isoform X5

    3. XM_054352135.1 → XP_054208110.1  rho GTPase-activating protein 26 isoform X20

    4. XM_054352146.1 → XP_054208121.1  rho GTPase-activating protein 26 isoform X30

    5. XM_054352147.1 → XP_054208122.1  rho GTPase-activating protein 26 isoform X32

    6. XM_054352118.1 → XP_054208093.1  rho GTPase-activating protein 26 isoform X33

    7. XM_054352125.1 → XP_054208100.1  rho GTPase-activating protein 26 isoform X34

    8. XM_054352116.1 → XP_054208091.1  rho GTPase-activating protein 26 isoform X3

    9. XM_054352121.1 → XP_054208096.1  rho GTPase-activating protein 26 isoform X7

    10. XM_054352124.1 → XP_054208099.1  rho GTPase-activating protein 26 isoform X10

    11. XM_054352128.1 → XP_054208103.1  rho GTPase-activating protein 26 isoform X13

    12. XM_054352133.1 → XP_054208108.1  rho GTPase-activating protein 26 isoform X18

    13. XM_054352117.1 → XP_054208092.1  rho GTPase-activating protein 26 isoform X4

    14. XM_054352114.1 → XP_054208089.1  rho GTPase-activating protein 26 isoform X1

    15. XM_054352115.1 → XP_054208090.1  rho GTPase-activating protein 26 isoform X2

    16. XM_054352120.1 → XP_054208095.1  rho GTPase-activating protein 26 isoform X6

    17. XM_054352122.1 → XP_054208097.1  rho GTPase-activating protein 26 isoform X8

    18. XM_054352123.1 → XP_054208098.1  rho GTPase-activating protein 26 isoform X9

    19. XM_054352131.1 → XP_054208106.1  rho GTPase-activating protein 26 isoform X16

    20. XM_054352137.1 → XP_054208112.1  rho GTPase-activating protein 26 isoform X22

    21. XM_054352136.1 → XP_054208111.1  rho GTPase-activating protein 26 isoform X21

    22. XM_054352144.1 → XP_054208119.1  rho GTPase-activating protein 26 isoform X29

    23. XM_054352143.1 → XP_054208118.1  rho GTPase-activating protein 26 isoform X28

    24. XM_054352141.1 → XP_054208116.1  rho GTPase-activating protein 26 isoform X26

    25. XM_054352142.1 → XP_054208117.1  rho GTPase-activating protein 26 isoform X27

    26. XM_054352129.1 → XP_054208104.1  rho GTPase-activating protein 26 isoform X14

    27. XM_054352139.1 → XP_054208114.1  rho GTPase-activating protein 26 isoform X24

    28. XM_054352145.1 → XP_054208120.1  rho GTPase-activating protein 26 isoform X20

    29. XM_054352130.1 → XP_054208105.1  rho GTPase-activating protein 26 isoform X35

    30. XM_054352126.1 → XP_054208101.1  rho GTPase-activating protein 26 isoform X11

    31. XM_054352127.1 → XP_054208102.1  rho GTPase-activating protein 26 isoform X12

    32. XM_054352132.1 → XP_054208107.1  rho GTPase-activating protein 26 isoform X17

    33. XM_054352140.1 → XP_054208115.1  rho GTPase-activating protein 26 isoform X25

    34. XM_054352134.1 → XP_054208109.1  rho GTPase-activating protein 26 isoform X19

    35. XM_054352148.1 → XP_054208123.1  rho GTPase-activating protein 26 isoform X31

    RNA

    1. XR_008487101.1 RNA Sequence

    2. XR_008487102.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNA1.1 GenPept UniProtKB/Swiss-Prot:Q9UNA1

    Gene LinkOut

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