Trpv3 transient receptor potential cation channel, subfamily V, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpv3provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily V, member 3provided by RGD
Primary source: RGD:1564531
See related: Ensembl:ENSRNOG00000019606 AllianceGenome:RGD:1564531
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium channel activity and identical protein binding activity. Involved in positive regulation of calcium ion import and response to heat. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Used to study alopecia and dermatitis. Human ortholog(s) of this gene implicated in colorectal cancer; congenital stationary night blindness; keratosis (multiple); migraine with aura; and schizophrenia. Orthologous to human TRPV3 (transient receptor potential cation channel subfamily V member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 30.3), Spleen (RPKM 9.3) and 6 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (58382054..58413657)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (57883546..57915865)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (59829755..59863780)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient Receptor Potential Vanilloid 3 (TRPV3) in the Cerebellum of Rat and Its Role in Motor Coordination.
Title: Transient Receptor Potential Vanilloid 3 (TRPV3) in the Cerebellum of Rat and Its Role in Motor Coordination.
MiR-103 could attenuate cardiomyocyte hypertrophy partly by reducing cardiac autophagy activity through the targeted inhibition of TRPV3 signalling.
Title: MiR-103 inhibiting cardiac hypertrophy through inactivation of myocardial cell autophagy via targeting TRPV3 channel in rat hearts.
the activation of TRPV3 aggravated pathological cardiac hypertrophy through calcineurin/NFATc3 signalling pathway and correlated with the protein expression levels of calcineurin, phosphorylated CaMKII and NFATc3, revealing that TRPV3 might be a potential therapeutic target for cardiac hypertrophy.
Title: Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin/NFATc3 pathway in rats.
Activation of the peripheral ion channel TRPM8 with menthol and rapid cooling (decrease in body temperature by 3C) led to 1.5-fold activation of the expression of TRPV3 ion channel gene in the posterior hypothalamus, but had no effect on the expression of this gene in the anterior hypothalamus.
Title: Effect of Activation of Peripheral Ion Channel TRPM8 on Gene Expression of Thermosensitive TRP Ion Channels in the Hypothalamus. Comparison with the Effect of Cooling.
TRPV3 activation exacerbated cardiac fibrosis by promoting cardiac fibroblast proliferation through the TGF-beta1 pathway.
Title: Transient receptor potential vanilloid-3 (TRPV3) activation plays a central role in cardiac fibrosis induced by pressure overload in rats via TGF-β(1) pathway.
TRPV3 is involved in hypoxia-induced pulmonary vascular remodeling and promotes proliferation of pulmonary artery smooth muscle cells and the effect is, at least in part, mediated via the PI3K/AKT pathway.
Title: The transient receptor potential vanilloid-3 regulates hypoxia-mediated pulmonary artery smooth muscle cells proliferation via PI3K/AKT signaling pathway.
Antagonism of TRPV3 receptors modulates activity of key classes of neurons in the pain pathway in a manner consistent with limiting pathological nociceptive signaling and was mediated by receptors in the periphery and brain. Blockade of TRPV3 receptors is likely an effective means to alleviate mechanical allodynia and nonevoked pain by blocking supraspinal TRPV3 receptors.
Title: TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats.
Results demonstrate a role for TRPV3 in driving mesolimbic-dopamine food-reward pathway, and underscores the importance of these channels in the ventral tegmental area as key components processing reward.
Title: Transient receptor potential vanilloid 3 (TRPV3) in the ventral tegmental area of rat: Role in modulation of the mesolimbic-dopamine reward pathway.
It was concluded that TRPV3 is expressed in a discrete subpopulation of vagal afferent neurons and may contribute to vagal afferent signaling either directly or in combination with TRPV1.
Title: Genetic and pharmacological evidence for low-abundance TRPV3 expression in primary vagal afferent neurons.
TRPV3 caused an endothelium-independent, IKCa-mediated dilation of the uterine radial artery. NO-PKG-mediated modulation of TRPV3 activity is lost in pregnancy, but this did not alter the response to vasodilator carvacrol.
Title: TRPV3 expression and vasodilator function in isolated uterine radial arteries from non-pregnant and pregnant rats.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

Go to the top of the page Help

Markers

RH139687 (e-PCR)
- UniSTS:221771

RH127973 (e-PCR)
- UniSTS:211283

PMC16295P1 (e-PCR)
- UniSTS:271475

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hair cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to temperature stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: transient receptor potential cation channel subfamily V member 3

Names: heat sensitive channel TRPV3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025757.2 → NP_001020928.2 transient receptor potential cation channel subfamily V member 3

See identical proteins and their annotated locations for NP_001020928.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

E9PU00, Q4QYD9

Related

ENSRNOP00000026596.2, ENSRNOT00000026596.4

Conserved Domains (2) summary

sd00045
Location:214 → 245

ANK; ANK repeat [structural motif]

cd22194
Location:67 → 755

TRPV3; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

58382054..58413657

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086602.2 → XP_038942530.1 transient receptor potential cation channel subfamily V member 3 isoform X3

UniProtKB/TrEMBL

E9PU00, Q4QYD9

Conserved Domains (2) summary

sd00045
Location:214 → 245

ANK; ANK repeat [structural motif]

cd22194
Location:67 → 755

TRPV3; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3
XM_008767860.4 → XP_008766082.1 transient receptor potential cation channel subfamily V member 3 isoform X4

UniProtKB/TrEMBL

Q4QYD9

Conserved Domains (5) summary

cd00204
Location:213 → 361

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:468 → 689

Ion_trans; Ion transport protein

pfam12796
Location:172 → 293

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:214 → 245

ANK; ANK repeat [structural motif]

cl11542
Location:490 → 609

EcsB; Bacterial ABC transporter protein EcsB
XM_017597463.2 → XP_017452952.1 transient receptor potential cation channel subfamily V member 3 isoform X1

UniProtKB/TrEMBL

Q4QYD9
XM_039086601.1 → XP_038942529.1 transient receptor potential cation channel subfamily V member 3 isoform X2

UniProtKB/TrEMBL

Q4QYD9

Conserved Domains (2) summary

sd00045
Location:216 → 247

ANK; ANK repeat [structural motif]

cd22194
Location:125 → 757

TRPV3; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3
XM_039086603.2 → XP_038942531.1 transient receptor potential cation channel subfamily V member 3 isoform X5

Conserved Domains (2) summary

sd00045
Location:216 → 247

ANK; ANK repeat [structural motif]

cl40437
Location:125 → 528

TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
XM_039086604.2 → XP_038942532.1 transient receptor potential cation channel subfamily V member 3 isoform X6

Conserved Domains (1) summary

cl40437
Location:1 → 474

TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
XM_039086605.2 → XP_038942533.1 transient receptor potential cation channel subfamily V member 3 isoform X6

Conserved Domains (1) summary

cl40437
Location:1 → 474

TRPV; Transient Receptor Potential channel, Vanilloid subfamily (TRPV)