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TRPV3 transient receptor potential cation channel subfamily V member 3 [ Homo sapiens (human) ]

Gene ID: 162514, updated on 26-Sep-2021

Summary

Official Symbol
TRPV3provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily V member 3provided by HGNC
Primary source
HGNC:HGNC:18084
See related
Ensembl:ENSG00000167723 MIM:607066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OLMS; VRL3; OLMS1; FNEPPK2
Summary
This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Biased expression in skin (RPKM 5.2), small intestine (RPKM 3.6) and 11 other tissues See more
Orthologs
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Genomic context

See TRPV3 in Genome Data Viewer
Location:
17p13.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (3510502..3557812, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3413796..3461106, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily E member 2 Neighboring gene spermatogenesis associated 22 Neighboring gene aspartoacylase Neighboring gene transient receptor potential cation channel subfamily V member 1 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 2 pseudogene Neighboring gene sedoheptulokinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium channel activity TAS
Traceable Author Statement
more info
 
enables ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in negative regulation of hair cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transient receptor potential cation channel subfamily V member 3
Names
VRL-3
vanilloid receptor-like 3
vanilloid receptor-related osmotically activated channel protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032144.2 RefSeqGene

    Range
    5184..52494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258205.2NP_001245134.1  transient receptor potential cation channel subfamily V member 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC025125, AC027796, BX537539, EU295940
    Consensus CDS
    CCDS58500.1
    UniProtKB/TrEMBL
    B2KYM6
    Related
    ENSP00000301365.4, ENST00000301365.8
    Conserved Domains (4) summary
    cd00204
    Location:213361
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:517689
    Ion_trans; Ion transport protein
    pfam12796
    Location:266366
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:214245
    ANK; ANK repeat [structural motif]
  2. NM_145068.4NP_659505.1  transient receptor potential cation channel subfamily V member 3 isoform 2

    See identical proteins and their annotated locations for NP_659505.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC025125, AC027796, AF514998, BX537539
    Consensus CDS
    CCDS11029.1
    UniProtKB/Swiss-Prot
    Q8NET8
    Related
    ENSP00000461518.2, ENST00000576742.6
    Conserved Domains (4) summary
    cd00204
    Location:213361
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00520
    Location:517689
    Ion_trans; Ion transport protein
    pfam12796
    Location:266366
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:214245
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    3510502..3557812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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