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    ACKR3 atypical chemokine receptor 3 [ Homo sapiens (human) ]

    Gene ID: 57007, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ACKR3provided by HGNC
    Official Full Name
    atypical chemokine receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:23692
    See related
    Ensembl:ENSG00000144476 MIM:610376; AllianceGenome:HGNC:23692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
    Summary
    This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 50.1), urinary bladder (RPKM 36.9) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q37.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (236537122..236582354)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (237027450..237072880)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (237478468..237490997)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:237300037-237301236 Neighboring gene IQCA1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237338113-237338612 Neighboring gene ribosomal protein L3 pseudogene 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:237348547-237349746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237458903-237459402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237459480-237460270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:237475953-237476828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:237476829-237477704 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:237488204-237489403 Neighboring gene uncharacterized LOC107986001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:237509317-237509817 Neighboring gene uncharacterized LOC105373946

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells. Sigmund EC, et al. PLoS One, 2023. PMID 37252916, Free PMC Article
    2. ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression. Tang C, et al. Mol Carcinog, 2023 Jun. PMID 36988340
    3. CXCR7 as a novel therapeutic target for advanced prostate cancer. Gritsina G, et al. Oncogene, 2023 Mar. PMID 36755058, Free PMC Article
    4. Structural snapshot of a β-arrestin-biased receptor. Sarma P, et al. Trends Pharmacol Sci, 2023 Jan. PMID 36057461, Free PMC Article
    5. Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases. Duval V, et al. Front Endocrinol (Lausanne), 2022. PMID 35846294, Free PMC Article

    See all (274) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crosstalk between purinergic receptor P2Y11 and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages.
      Title: Crosstalk between purinergic receptor P2Y(11) and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages.
    2. Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors.
      Title: Exploring the CXCR4/CXCR7/CXCL12 Axis in Primary Desmoid Tumors.
    3. Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer.
      Title: Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer.
    4. Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation.
      Title: Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation.
    5. CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications.
      Title: CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications.
    6. BMP2 induces osteogenic differentiation through ACKR3 in mesenchymal stem cells.
      Title: BMP2 induces osteogenic differentiation through ACKR3 in mesenchymal stem cells.
    7. Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells.
      Title: Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells.
    8. ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression.
      Title: ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression.
    9. CXCR7 as a novel therapeutic target for advanced prostate cancer.
      Title: CXCR7 as a novel therapeutic target for advanced prostate cancer.
    10. ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production.
      Title: ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production.
    Submit: New GeneRIF Correction See all GeneRIFs (247)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Oculomotor-abducens synkinesis
    MedGen: C5543116 OMIM: 619215 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-X-C chemokine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables C-X-C chemokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scavenger receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oculomotor nerve development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mesenchymal stem cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    atypical chemokine receptor 3
    Names
    C-X-C chemokine receptor type 7
    G protein-coupled receptor
    G-protein coupled receptor 159
    G-protein coupled receptor RDC1 homolog
    chemokine (C-X-C motif) receptor 7
    chemokine orphan receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020311.3 → NP_064707.1  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_064707.1

      Status: REVIEWED

      Source sequence(s)
      BC036661, BP426139, DQ822477
      Consensus CDS
      CCDS2516.1
      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
      Related
      ENSP00000272928.3, ENST00000272928.4
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      236537122..236582354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246098.4 → XP_005246155.1  atypical chemokine receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_005246155.1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_047445135.1 → XP_047301091.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    3. XM_047445136.1 → XP_047301092.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    4. XM_005246097.4 → XP_005246154.1  atypical chemokine receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_005246154.1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986
      Conserved Domains (1) summary
      pfam00001
      Location:62 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      237027450..237072880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343068.1 → XP_054199043.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    2. XM_054343064.1 → XP_054199039.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    3. XM_054343067.1 → XP_054199042.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    4. XM_054343065.1 → XP_054199040.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    5. XM_054343063.1 → XP_054199038.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    6. XM_054343066.1 → XP_054199041.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      A8K6J4, P25106, Q53RV4, Q8NE10, Q92938, Q92986

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047841.1: Suppressed sequence

      Description
      NM_001047841.1: This RefSeq was permanently suppressed because it has a none consensus splice site that does not have enough supporting evidence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25106.3 GenPept UniProtKB/Swiss-Prot:P25106

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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