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Ackr3 atypical chemokine receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 12778, updated on 8-Dec-2018

Summary

Official Symbol
Ackr3provided by MGI
Official Full Name
atypical chemokine receptor 3provided by MGI
Primary source
MGI:MGI:109562
See related
Ensembl:ENSMUSG00000044337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1; AW541270
Expression
Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 20 other tissues See more
Orthologs

Genomic context

See Ackr3 in Genome Data Viewer
Location:
1 D; 1 45.28 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (90203980..90215724)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (92100578..92112863)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene IQ motif containing with AAA domain Neighboring gene RIKEN cDNA 4930434B07 gene Neighboring gene predicted gene, 34930 Neighboring gene RIKEN cDNA 2700003A03 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
scavenger receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mesenchymal stem cell migration ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
atypical chemokine receptor 3
Names
C-X-C chemokine receptor type 7
G-protein coupled receptor RDC1 homolog
chemokine (C-X-C motif) receptor 7
chemokine orphan receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271607.1NP_001258536.1  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_001258536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC110261, AC120878
    Consensus CDS
    CCDS15152.1
    UniProtKB/Swiss-Prot
    P56485
    Conserved Domains (1) summary
    pfam00001
    Location:62315
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_007722.4NP_031748.2  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_031748.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC110261, AK031100, BQ033958
    Consensus CDS
    CCDS15152.1
    UniProtKB/Swiss-Prot
    P56485
    Related
    ENSMUSP00000069114.4, ENSMUST00000065587.4
    Conserved Domains (1) summary
    pfam00001
    Location:62315
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    90203980..90215724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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