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Ackr3 atypical chemokine receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 12778, updated on 14-Oct-2021

Summary

Official Symbol
Ackr3provided by MGI
Official Full Name
atypical chemokine receptor 3provided by MGI
Primary source
MGI:MGI:109562
See related
Ensembl:ENSMUSG00000044337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1; AW541270
Expression
Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 20 other tissues See more
Orthologs
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Genomic context

See Ackr3 in Genome Data Viewer
Location:
1 D; 1 45.28 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (90131702..90143446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90203980..90215724)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (92100578..92112863)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing with AAA domain Neighboring gene RIKEN cDNA 4930434B07 gene Neighboring gene RIKEN cDNA 2700003A03 gene Neighboring gene predicted gene, 34992

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-X-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables chemokine binding IEA
Inferred from Electronic Annotation
more info
 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
enables scavenger receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mesenchymal stem cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
atypical chemokine receptor 3
Names
C-X-C chemokine receptor type 7
G-protein coupled receptor RDC1 homolog
chemokine (C-X-C motif) receptor 7
chemokine orphan receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271607.1NP_001258536.1  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_001258536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC110261, AC120878
    Consensus CDS
    CCDS15152.1
    UniProtKB/Swiss-Prot
    P56485
    Conserved Domains (1) summary
    cd14987
    Location:45326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_007722.4NP_031748.2  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_031748.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC110261, AK031100, BQ033958
    Consensus CDS
    CCDS15152.1
    UniProtKB/Swiss-Prot
    P56485
    Related
    ENSMUSP00000069114.5, ENSMUST00000065587.5
    Conserved Domains (1) summary
    cd14987
    Location:45326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    90131702..90143446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157069.1XP_036012962.1  atypical chemokine receptor 3 isoform X1

    Conserved Domains (1) summary
    cd14987
    Location:45326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
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