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    SKM1 putative serine/threonine protein kinase SKM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854036, updated on 13-Apr-2024

    Summary

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    Gene symbol
    SKM1
    Gene description
    putative serine/threonine protein kinase SKM1
    Primary source
    SGD:S000005473
    Locus tag
    YOL113W
    See related
    AllianceGenome:SGD:S000005473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in negative regulation of macromolecule metabolic process; septum digestion after cytokinesis; and sterol import. Located in nucleus and plasma membrane. Human ortholog(s) of this gene implicated in breast cancer; non-syndromic X-linked intellectual disability 30; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PAK3 (p21 (RAC1) activated kinase 3); and PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (104326..106293)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene non-canonical poly(A) polymerase PAP2 Neighboring gene Pth4p Neighboring gene Rab GTPase-activating protein MSB4 Neighboring gene Mdy2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Yu JW, et al. Mol Cell, 2004 Mar 12. PMID 15023338
    2. Characterization of SKM1, a Saccharomyces cerevisiae gene encoding a novel Ste20/PAK-like protein kinase. Martín H, et al. Mol Microbiol, 1997 Feb. PMID 9044278
    3. Role of Cdc42-Cla4 interaction in the pheromone response of Saccharomyces cerevisiae. Heinrich M, et al. Eukaryot Cell, 2007 Feb. PMID 17189484, Free PMC Article
    4. Analysis of the mechanisms of action of the Saccharomyces cerevisiae dominant lethal cdc42G12V and dominant negative cdc42D118A mutations. Davis CR, et al. J Biol Chem, 1998 Jan 9. PMID 9422741
    5. Characterisation of gene expression profiles of yeast cells expressing BRCA1 missense variants. Di Cecco L, et al. Eur J Cancer, 2009 Aug. PMID 19493677

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that the Cdc42 effectors Ste20, Cla4, and Skm1 translocate into the nucleus, where they modulate expression of sterol uptake genes via Sut1, thereby controlling sterol homeostasis.
      Title: The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of sterol import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase SKM1
    NP_014528.1
    • Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      104326..106293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183367.1 → NP_014528.1  TPA: putative serine/threonine protein kinase SKM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1V4, E9P934, Q06940, Q12469
      UniProtKB/TrEMBL
      A0A8H4BUG6, G2WMC3, N1NW98
      Conserved Domains (3) summary
      cd13279
      Location:4 → 113
      PH_Cla4_Ste20; Pleckstrin homology (PH) domain
      cd06614
      Location:359 → 640
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
      pfam00786
      Location:122 → 180
      PBD; P21-Rho-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12469.1

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