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    A3galt2 alpha 1,3-galactosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171553, updated on 5-Mar-2024

    Summary

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    Official Symbol
    A3galt2provided by RGD
    Official Full Name
    alpha 1,3-galactosyltransferase 2provided by RGD
    Primary source
    RGD:727913
    See related
    Ensembl:ENSRNOG00000005935 AllianceGenome:RGD:727913
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity and alpha-1,3-galactosyltransferase activity. Involved in cellular response to manganese ion and lipid glycosylation. Acts upstream of or within glycosphingolipid biosynthetic process. Located in Golgi apparatus and vesicle. Orthologous to human A3GALT2 (alpha 1,3-galactosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 128.1), Uterus (RPKM 93.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (146385725..146398156)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141101329..141113760)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (146933592..146945882)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 12 Neighboring gene polyhomeotic homolog 2 Neighboring gene zinc finger protein 362 Neighboring gene uncharacterized LOC102551009

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids. Keusch JJ, et al. J Biol Chem, 2000 Aug 18. PMID 10854427
    2. UDP-galactose:globotriaosylceramide alpha-galactosyltransferase activity in rat pheochromocytoma (PC12h) cells. Pal S, et al. J Lipid Res, 1992 Mar. PMID 1569388
    3. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. Christiansen D, et al. PLoS Biol, 2008 Jul 15. PMID 18630988, Free PMC Article
    4. Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat. Fullmer JM, et al. J Comp Neurol, 2007 Mar 1. PMID 17206613
    5. Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways. Taylor SG, et al. Glycobiology, 2003 May. PMID 12626403

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,3-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables alpha-1,3-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-1,3-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to manganese ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycosphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-1,3-galactosyltransferase 2
    Names
    iGb3 synthase
    iGb3S
    isoglobotriaosylceramide synthase
    NP_612533.1
    XP_038965168.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138524.2 → NP_612533.1  alpha-1,3-galactosyltransferase 2

      See identical proteins and their annotated locations for NP_612533.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061714
      UniProtKB/Swiss-Prot
      A0A4Z3, A2JQW1
      UniProtKB/TrEMBL
      A0A8L2Q356, A6ISF7
      Related
      ENSRNOP00000007851.5, ENSRNOT00000007851.6
      Conserved Domains (1) summary
      cd02515
      Location:67 → 338
      Glyco_transf_6; Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      146385725..146398156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109240.1 → XP_038965168.1  alpha-1,3-galactosyltransferase 2 isoform X1

      Conserved Domains (1) summary
      cl11394
      Location:69 → 292
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4Z3.1 GenPept UniProtKB/Swiss-Prot:A0A4Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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