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A3GALT2 alpha 1,3-galactosyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 127550, updated on 5-Jan-2022

Summary

Official Symbol
A3GALT2provided by HGNC
Official Full Name
alpha 1,3-galactosyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:30005
See related
Ensembl:ENSG00000184389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGB3S; IGBS3S; A3GALT2P
Summary
Predicted to enable N-acetyllactosaminide 3-alpha-galactosyltransferase activity and alpha-1,3-galactosyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to act upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and vesicle. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See A3GALT2 in Genome Data Viewer
Location:
1p35.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (33306766..33321098, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33772367..33786699, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene antizyme inhibitor 2 Neighboring gene tripartite motif containing 62 Neighboring gene Sharpr-MPRA regulatory region 4113 Neighboring gene zinc finger protein 362 Neighboring gene RN7SK pseudogene 16 Neighboring gene microRNA 3605 Neighboring gene polyhomeotic homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT enables alpha-1,3-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to manganese ion IEA
Inferred from Electronic Annotation
more info
 
involved_in glycosphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
alpha-1,3-galactosyltransferase 2
Names
alpha 1,3-galactosyltransferase 2, pseudogene
iGb3 synthase
isoglobotriaosylceramide synthase
NP_001073907.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080438.1NP_001073907.1  alpha-1,3-galactosyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    AL513327
    Consensus CDS
    CCDS60080.1
    UniProtKB/Swiss-Prot
    U3KPV4
    Related
    ENSP00000475261.1, ENST00000442999.3
    Conserved Domains (1) summary
    cd02515
    Location:68339
    Glyco_transf_6; Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    33306766..33321098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012483.1: Suppressed sequence

    Description
    NG_012483.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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