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    Ppp1r21 protein phosphatase 1, regulatory subunit 21 [ Mus musculus (house mouse) ]

    Gene ID: 73825, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp1r21provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 21provided by MGI
    Primary source
    MGI:MGI:1921075
    See related
    Ensembl:ENSMUSG00000034709 AllianceGenome:MGI:1921075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klraq1; Ccdc128; 1110018J12Rik
    Summary
    Predicted to be located in endosome. Predicted to be active in early endosome. Is expressed in nervous system; neural retina; and thymus primordium. Orthologous to human PPP1R21 (protein phosphatase 1 regulatory subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 11.8), cerebellum adult (RPKM 10.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E4; 17 58.02 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88837552..88895795)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (88530124..88588367)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43553 Neighboring gene predicted gene, 23947 Neighboring gene STARR-positive B cell enhancer ABC_E5644 Neighboring gene forkhead box N2 Neighboring gene STARR-seq mESC enhancer starr_43555 Neighboring gene STARR-seq mESC enhancer starr_43556 Neighboring gene predicted gene, 57646 Neighboring gene STARR-seq mESC enhancer starr_43557 Neighboring gene STARR-seq mESC enhancer starr_43559 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88929251-88929552 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88980789-88981089 Neighboring gene stonin 1 Neighboring gene predicted gene, 31704 Neighboring gene predicted gene, 31903 Neighboring gene predicted gene, 38460

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117934

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 21
    Names
    KLRAQ motif containing 1
    KLRAQ motif-containing protein 1
    coiled-coil domain containing 128
    coiled-coil domain-containing protein 128

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028658.4 → NP_082934.3  protein phosphatase 1 regulatory subunit 21

      See identical proteins and their annotated locations for NP_082934.3

      Status: VALIDATED

      Source sequence(s)
      BC137673, BQ176826, BY205567
      Consensus CDS
      CCDS29023.1
      UniProtKB/Swiss-Prot
      B2RPZ6, Q3KQN7, Q3TDD9, Q3U2U9, Q8BHS9, Q9D1A1
      Related
      ENSMUSP00000048443.7, ENSMUST00000038551.8
      Conserved Domains (2) summary
      pfam10205
      Location:11 → 111
      KLRAQ; Predicted coiled-coil domain-containing protein
      pfam10212
      Location:255 → 771
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      88837552..88895795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317677.1 → XP_017173166.1  protein phosphatase 1 regulatory subunit 21 isoform X1

      Conserved Domains (1) summary
      pfam10212
      Location:135 → 423
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TDD9.2 GenPept UniProtKB/Swiss-Prot:Q3TDD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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