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PPP1R21 protein phosphatase 1 regulatory subunit 21 [ Homo sapiens (human) ]

Gene ID: 129285, updated on 10-Oct-2019

Summary

Official Symbol
PPP1R21provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 21provided by HGNC
Primary source
HGNC:HGNC:30595
See related
Ensembl:ENSG00000162869 MIM:618159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLRAQ1; CCDC128
Expression
Ubiquitous expression in thyroid (RPKM 15.5), kidney (RPKM 15.1) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R21 in Genome Data Viewer
Location:
2p16.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (48440766..48515392)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (48667908..48742531)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724008 Neighboring gene forkhead box N2 Neighboring gene RNA, U4 small nuclear 49, pseudogene Neighboring gene STON1-GTF2A1L readthrough Neighboring gene RNA, U6 small nuclear 282, pseudogene Neighboring gene stonin 1 Neighboring gene general transcription factor IIA subunit 1 like Neighboring gene tumor protein, translationally-controlled 1 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16566, MGC111781

Gene Ontology Provided by GOA

Component Evidence Code Pubs
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 21
Names
KLRAQ motif containing 1
KLRAQ motif-containing protein 1
coiled-coil domain containing 128
coiled-coil domain-containing protein 128

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135629.3NP_001129101.1  protein phosphatase 1 regulatory subunit 21 isoform 1

    See identical proteins and their annotated locations for NP_001129101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AA449986, AC093635, AK172762, AY134855, BC117279
    Consensus CDS
    CCDS46278.1
    UniProtKB/Swiss-Prot
    Q6ZMI0
    Related
    ENSP00000294952.8, ENST00000294952.13
    Conserved Domains (3) summary
    pfam10205
    Location:11111
    KLRAQ; Predicted coiled-coil domain-containing protein
    pfam10212
    Location:255771
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein
    cl25732
    Location:5274
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001193475.1NP_001180404.1  protein phosphatase 1 regulatory subunit 21 isoform 5

    See identical proteins and their annotated locations for NP_001180404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. The resulting protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AA449986, AK172762, AY134855, BC143466
    Consensus CDS
    CCDS54358.1
    UniProtKB/Swiss-Prot
    Q6ZMI0
    Related
    ENSP00000415696.2, ENST00000449090.6
    Conserved Domains (2) summary
    pfam10205
    Location:11111
    KLRAQ; Predicted coiled-coil domain-containing protein
    pfam10212
    Location:255729
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein
  3. NM_152994.5NP_694539.1  protein phosphatase 1 regulatory subunit 21 isoform 2

    See identical proteins and their annotated locations for NP_694539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA449986, AC093635, AK172762, AY134855
    Consensus CDS
    CCDS1839.1
    UniProtKB/Swiss-Prot
    Q6ZMI0
    Related
    ENSP00000281394.4, ENST00000281394.8
    Conserved Domains (2) summary
    pfam10205
    Location:11111
    KLRAQ; Predicted coiled-coil domain-containing protein
    pfam10212
    Location:255760
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

RNA

  1. NR_024188.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA449986, AC093635, AK122900, AK172762, AY134855, BC117279
    Related
    ENST00000416913.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    48440766..48515392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003301.1XP_016858790.1  protein phosphatase 1 regulatory subunit 21 isoform X1

  2. XM_017003302.1XP_016858791.1  protein phosphatase 1 regulatory subunit 21 isoform X2

RNA

  1. XR_001738609.1 RNA Sequence

  2. XR_001738608.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135630.1: Suppressed sequence

    Description
    NM_001135630.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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