SSTR3 somatostatin receptor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SSTR3provided by HGNC
Official Full Name: somatostatin receptor 3provided by HGNC
Primary source: HGNC:HGNC:11332
See related: Ensembl:ENSG00000278195 MIM:182453; AllianceGenome:HGNC:11332
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SS3R; SST3; SS3-R; SS-3-R; SSR-28
Summary: This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression: Biased expression in testis (RPKM 3.5), brain (RPKM 1.1) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (37204237..37220548, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (37664155..37680477, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (37600277..37608517, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
Title: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
the C-terminal phosphorylation motif of the human sst3 receptor that regulates its agonist-promoted phosphorylation, beta-arrestin recruitment, and internalization of this clinically relevant receptor, is reported.
Title: Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking.
Data showed that the distribution of somatostatin receptor (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (54.8%), SSTR1 (53.3%), SSTR4 (51.8%), SSTR5 (33.7%), and SSTR3 (28.6%).
Title: Prognostic Value of Somatostatin Receptor Subtypes in Pancreatic Neuroendocrine Tumors.
Data indicate that somatostatin receptor scintigraphy (SRS) and immunohistochemical results for somatostatin and dopamine receptors sstr2, sstr3, sstr5 and D2R were compared in neuroendocrine neoplasms tissues.
Title: Somatostatin and dopamine receptor expression in neuroendocrine neoplasms: correlation of immunohistochemical findings with somatostatin receptor scintigraphy visual scores.
findings provide new insights in understanding the antiproliferative role of SSTR3 in breast tumor biology.
Title: Human somatostatin receptor-3 distinctively induces apoptosis in MCF-7 and cell cycle arrest in MDA-MB-231 breast cancer cells.
An immunohistochemical investigation of the expression of somatostatin receptor subtypes
Title: An immunohistochemical investigation of the expression of somatostatin receptor subtypes - should therapeutic trials be performed to determine the efficacy of somatostatin analogs in treating advanced thyroid malignances?
In conclusions, in CNFAs, high expression of somatostatin receptors is much less common than that of D2R
Title: Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas.
SSTR2A and SSTR3 are more likely to be expressed in SDH-deficient pheochromocytomas/paragangliomas compared with tumors demonstrating normal SDHB staining pattern.
Title: Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas.
constitutive SSTR3 activity mediates transcriptional repression of GH.
Title: Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis.
High SSTR3 expression is associated with gallbladder cancer.
Title: Somatostatin receptors 3, 4 and 5 play important roles in gallbladder cancer.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Joint influence of small-effect genetic variants on human longevity. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G67502 (e-PCR)
- UniSTS:186763

G67503 (e-PCR)
- UniSTS:186764

G67504 (e-PCR)
- UniSTS:186765

SSTR3__5322 (e-PCR)
- UniSTS:464568

NoName (e-PCR)
- UniSTS:480983

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables somatostatin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IEA Inferred from Electronic Annotation more info
involved_in somatostatin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary membrane	TAS Traceable Author Statement more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: somatostatin receptor type 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001051.5 → NP_001042.1 somatostatin receptor type 3

See identical proteins and their annotated locations for NP_001042.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK291165, BF514979, Z82188

Consensus CDS

CCDS13944.1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7

UniProtKB/TrEMBL

Q86YF2

Related

ENSP00000480971.1, ENST00000610913.2

Conserved Domains (2) summary

pfam00001
Location:61 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:55 → 158

7tm_4; Olfactory receptor
NM_001278687.2 → NP_001265616.1 somatostatin receptor type 3

See identical proteins and their annotated locations for NP_001265616.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BF514979, BU584980, KF511460, Z82188

Consensus CDS

CCDS13944.1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7

UniProtKB/TrEMBL

Q86YF2

Related

ENSP00000481325.1, ENST00000617123.1

Conserved Domains (2) summary

pfam00001
Location:61 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:55 → 158

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

37204237..37220548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005261721.5 → XP_005261778.1 somatostatin receptor type 3 isoform X1

See identical proteins and their annotated locations for XP_005261778.1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7

UniProtKB/TrEMBL

Q86YF2

Conserved Domains (2) summary

pfam00001
Location:61 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:55 → 158

7tm_4; Olfactory receptor
XM_017028924.2 → XP_016884413.1 somatostatin receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7

UniProtKB/TrEMBL

Q86YF2

Conserved Domains (2) summary

pfam00001
Location:61 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:55 → 158

7tm_4; Olfactory receptor
XM_047441473.1 → XP_047297429.1 somatostatin receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7
XM_006724311.4 → XP_006724374.1 somatostatin receptor type 3 isoform X1

See identical proteins and their annotated locations for XP_006724374.1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7

UniProtKB/TrEMBL

Q86YF2

Conserved Domains (2) summary

pfam00001
Location:61 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:55 → 158

7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

NC_060946.1 Alternate T2T-CHM13v2.0

Range

37664155..37680477 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054325877.1 → XP_054181852.1 somatostatin receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7
XM_054325876.1 → XP_054181851.1 somatostatin receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7
XM_054325875.1 → XP_054181850.1 somatostatin receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A8K550, P32745, Q53ZR7