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Sstr3 somatostatin receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 20607, updated on 26-Sep-2022

Summary

Official Symbol
Sstr3provided by MGI
Official Full Name
somatostatin receptor 3provided by MGI
Primary source
MGI:MGI:98329
See related
Ensembl:ENSMUSG00000044933 AllianceGenome:MGI:98329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sst3; Smstr3; Smstr-3
Summary
Enables signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in ciliary membrane and non-motile cilium. Is expressed in several structures, including adrenal gland; brain; gallbladder; genitourinary system; and gut. Orthologous to human SSTR3 (somatostatin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 2.1) and 9 other tissues See more
Orthologs
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Genomic context

See Sstr3 in Genome Data Viewer
Location:
15 E1; 15 37.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78421214..78433565, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78537014..78549365, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene interleukin 2 receptor, beta chain Neighboring gene C1q and tumor necrosis factor related protein 6 Neighboring gene L antigen family, member 3 pseudogene Neighboring gene Rac family small GTPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables somatostatin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
somatostatin receptor type 3
Names
SS-3-R
SS3-R
SS3R
SSR-28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356961.1NP_001343890.1  somatostatin receptor type 3

    Status: VALIDATED

    Source sequence(s)
    AL590144
    Consensus CDS
    CCDS27617.1
    UniProtKB/Swiss-Prot
    Q3UVV5
    Conserved Domains (2) summary
    cd14964
    Location:4872
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001411768.1NP_001398697.1  somatostatin receptor type 3

    Status: VALIDATED

    Source sequence(s)
    AL590144
  3. NM_009218.3NP_033244.2  somatostatin receptor type 3

    See identical proteins and their annotated locations for NP_033244.2

    Status: VALIDATED

    Source sequence(s)
    AL590144
    Consensus CDS
    CCDS27617.1
    UniProtKB/Swiss-Prot
    P30935, Q3UVV5
    Related
    ENSMUSP00000058040.3, ENSMUST00000053239.4
    Conserved Domains (2) summary
    cd14964
    Location:4872
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78421214..78433565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245531.2XP_011243833.1  somatostatin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_011243833.1

    UniProtKB/Swiss-Prot
    P30935, Q3UVV5
    Conserved Domains (2) summary
    cd14964
    Location:4872
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006520670.5XP_006520733.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    P30935, Q3UVV5
    Conserved Domains (2) summary
    cd14964
    Location:4872
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily