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    mik1 M phase inhibitor protein kinase Mik1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540885, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mik1
    Official Full Name
    M phase inhibitor protein kinase Mik1
    Primary source
    PomBase:SPBC660.14
    Locus tag
    SPOM_SPBC660.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mik1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (221298..224117)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene single-stranded telomeric-binding protein Tgc1 Neighboring gene ncRNA Neighboring gene ergothioneine biosynthesis methyltransferase Egt2 Neighboring gene ncRNA Neighboring gene DNA replication factor A subunit Ssb1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cleavage factor complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carboxy-terminal phosphorylation sites in Cdc25 contribute to enforcement of the DNA damage and replication checkpoints in fission yeast. Frazer C, et al. Curr Genet, 2012 Aug. PMID 22806395
    2. The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. Den Haese GJ, et al. Mol Biol Cell, 1995 Apr. PMID 7626804, Free PMC Article
    3. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Lundgren K, et al. Cell, 1991 Mar 22. PMID 1706223
    4. mik1(+) G1-S transcription regulates mitotic entry in fission yeast. Ng SS, et al. FEBS Lett, 2001 Aug 17. PMID 11513869
    5. mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15. Lee MS, et al. J Biol Chem, 1994 Dec 2. PMID 7982971

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mik1 and Mrc1 have roles in checkpoint regulation of G1/S transcription in response to replicative stress
      Title: The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    M phase inhibitor protein kinase Mik1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      221298..224117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021000.3 → NP_595093.1  M phase inhibitor protein kinase Mik1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595093.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P30290
      Conserved Domains (2) summary
      smart00220
      Location:300 → 556
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14052
      Location:288 → 556
      PTKc_Wee1_fungi; Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins
    Nucleotide Protein
    Heading Accession and Version

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