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    CREB5 cAMP responsive element binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 9586, updated on 10-Apr-2024

    Summary

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    Official Symbol
    CREB5provided by HGNC
    Official Full Name
    cAMP responsive element binding protein 5provided by HGNC
    Primary source
    HGNC:HGNC:16844
    See related
    Ensembl:ENSG00000146592 MIM:618262; AllianceGenome:HGNC:16844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CREB-5; CREBPA; CRE-BPA
    Summary
    The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7p15.1-p14.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (28299321..28825894)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (28436682..28963385)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (28338940..28865511)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene JAZF zinc finger 1 Neighboring gene MPRA-validated peak6455 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25794 Neighboring gene JAZF1 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:28330425-28331392 and GRCh37_chr7:28331393-28332360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28332361-28333326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28350942-28351442 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:28398093-28398687 Neighboring gene peptidylprolyl isomerase A pseudogene 80 Neighboring gene Sharpr-MPRA regulatory region 5389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25797 Neighboring gene Sharpr-MPRA regulatory region 14916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18046 Neighboring gene VISTA enhancer hs1604 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:28651065-28652264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28682874-28683374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28683375-28683875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28725036-28725544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25799 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene NANOG hESC enhancer GRCh37_chr7:28808272-28808863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28832834-28833543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:28877832-28878523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18047 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29025827-29026326 Neighboring gene CPVL antisense RNA 2 Neighboring gene TLR4 interactor with leucine rich repeats Neighboring gene carboxypeptidase vitellogenic like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance. Li J, et al. J Clin Lab Anal, 2022 Oct. PMID 36087301, Free PMC Article
    2. Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank. Yanik EL, et al. J Bone Joint Surg Am, 2021 Jul 21. PMID 33979311, Free PMC Article
    3. CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET. Wang S, et al. J Exp Clin Cancer Res, 2020 Aug 25. PMID 32843066, Free PMC Article
    4. Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology. Nho K, et al. Alzheimers Dement, 2020 Sep. PMID 32755048, Free PMC Article
    5. CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer. Hwang JH, et al. Cell Rep, 2019 Nov 19. PMID 31747605, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes.
      Title: Plasma microRNA-320c as a Potential Biomarker for the Severity of Knee Osteoarthritis and Regulates cAMP Responsive Element Binding Protein 5 (CREB5) in Chondrocytes.
    2. SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.
      Title: SPOP promotes CREB5 ubiquitination to inhibit MET signaling in liver cancer.
    3. The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
      Title: The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.
    4. Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.
      Title: Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.
    5. Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
      Title: Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.
    6. microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway.
      Title: microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway.
    7. The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.
      Title: The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.
    8. CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies.
      Title: CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies.
    9. Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank.
      Title: Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank.
    10. Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.
      Title: Genome-wide transcriptome analysis identifies novel dysregulated genes implicated in Alzheimer's pathology.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    EBI GWAS Catalog
    Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
    EBI GWAS Catalog
    Genome-wide association study of co-occurring anxiety in major depression.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclic AMP-responsive element-binding protein 5
    Names
    cAMP response element-binding protein CRE-BPa
    cAMP-response element-binding protein A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011666.3 → NP_001011666.1  cyclic AMP-responsive element-binding protein 5 isoform delta

      See identical proteins and their annotated locations for NP_001011666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream start codon, compared to variant 1. It encodes isoform delta which is shorter and contains a distinct N-terminus compared to isoform alpha.
      Source sequence(s)
      AC005013, BC059400, BQ130001
      Consensus CDS
      CCDS43563.1
      UniProtKB/TrEMBL
      Q59G47
      Related
      ENSP00000379592.2, ENST00000396298.6
      Conserved Domains (1) summary
      cd14687
      Location:238 → 297
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    2. NM_004904.4 → NP_004895.2  cyclic AMP-responsive element-binding protein 5 isoform beta

      See identical proteins and their annotated locations for NP_004895.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' exon and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform beta which has a shorter N-terminus compared to isoform alpha.
      Source sequence(s)
      AB451409, AC005013, AC006980, BQ130001, L05911
      Consensus CDS
      CCDS5418.1
      UniProtKB/Swiss-Prot
      Q02930
      Related
      ENSP00000379594.2, ENST00000396300.6
      Conserved Domains (1) summary
      cd14687
      Location:370 → 429
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    3. NM_182898.4 → NP_878901.2  cyclic AMP-responsive element-binding protein 5 isoform alpha

      See identical proteins and their annotated locations for NP_878901.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (alpha).
      Source sequence(s)
      AB451409, AC005013, AC006367, BQ130001, L05515
      Consensus CDS
      CCDS5417.1
      UniProtKB/Swiss-Prot
      A8KA51, B4DU13, B5BUH3, C9JK47, Q02930, Q05886, Q06246, Q75N02, Q86UJ9
      Related
      ENSP00000350359.2, ENST00000357727.7
      Conserved Domains (1) summary
      cd14687
      Location:377 → 436
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    4. NM_182899.5 → NP_878902.2  cyclic AMP-responsive element-binding protein 5 isoform gamma

      See identical proteins and their annotated locations for NP_878902.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons and uses an alternate 5' terminal exon which results in the use of a downstream in-frame start codon, compared to variant 1. It encodes isoform gamma which has a shorter N-terminus compared to isoform alpha.
      Source sequence(s)
      AB451409, AC005013, AC006367, BQ130001, L05913
      Consensus CDS
      CCDS43562.1
      UniProtKB/Swiss-Prot
      Q02930
      Related
      ENSP00000379593.2, ENST00000396299.6
      Conserved Domains (1) summary
      cd14687
      Location:344 → 403
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      28299321..28825894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012807.2 → XP_016868296.1  cyclic AMP-responsive element-binding protein 5 isoform X2

    2. XM_017012808.2 → XP_016868297.1  cyclic AMP-responsive element-binding protein 5 isoform X3

      UniProtKB/Swiss-Prot
      A8KA51, B4DU13, B5BUH3, C9JK47, Q02930, Q05886, Q06246, Q75N02, Q86UJ9
      Conserved Domains (1) summary
      cd14687
      Location:377 → 436
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    3. XM_017012806.2 → XP_016868295.1  cyclic AMP-responsive element-binding protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q02930
      Conserved Domains (1) summary
      cd14687
      Location:370 → 429
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    4. XM_005249906.2 → XP_005249963.1  cyclic AMP-responsive element-binding protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005249963.1

      UniProtKB/Swiss-Prot
      Q02930
      Conserved Domains (1) summary
      cd14687
      Location:370 → 429
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    5. XM_024447005.2 → XP_024302773.1  cyclic AMP-responsive element-binding protein 5 isoform X5

      Related
      ENSP00000387197.1, ENST00000409603.5
      Conserved Domains (1) summary
      cd14687
      Location:344 → 403
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    6. XM_047421068.1 → XP_047277024.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    7. XM_047421069.1 → XP_047277025.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    8. XM_047421067.1 → XP_047277023.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    9. XM_047421070.1 → XP_047277026.1  cyclic AMP-responsive element-binding protein 5 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      28436682..28963385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359399.1 → XP_054215374.1  cyclic AMP-responsive element-binding protein 5 isoform X8

    2. XM_054359397.1 → XP_054215372.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    3. XM_054359395.1 → XP_054215370.1  cyclic AMP-responsive element-binding protein 5 isoform X7

    4. XM_054359400.1 → XP_054215375.1  cyclic AMP-responsive element-binding protein 5 isoform X5

    5. XM_054359401.1 → XP_054215376.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    6. XM_054359396.1 → XP_054215371.1  cyclic AMP-responsive element-binding protein 5 isoform X2

    7. XM_054359398.1 → XP_054215373.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    8. XM_054359402.1 → XP_054215377.1  cyclic AMP-responsive element-binding protein 5 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02930.3 GenPept UniProtKB/Swiss-Prot:Q02930

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