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Creb5 cAMP responsive element binding protein 5 [ Mus musculus (house mouse) ]

Gene ID: 231991, updated on 12-Mar-2023

Summary

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Official Symbol
Creb5provided by MGI
Official Full Name
cAMP responsive element binding protein 5provided by MGI
Primary source
MGI:MGI:2443973
See related
Ensembl:ENSMUSG00000053007 AllianceGenome:MGI:2443973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crebpa; CRE-BPa; 9430076C15Rik; D430026C09Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in white fat cell differentiation. Acts upstream of or within adipose tissue development; fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including forelimb bud; hindlimb phalanx; limb mesenchyme; oral epithelium; and telencephalon ventricular layer. Orthologous to human CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 2.1), subcutaneous fat pad adult (RPKM 1.0) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Creb5 in Genome Data Viewer
Location:
6 B3; 6 25.9 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (53264154..53677349)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (53287226..53700364)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4872 Neighboring gene predicted gene, 33348 Neighboring gene predicted gene, 25818 Neighboring gene predicted gene, 38815 Neighboring gene predicted gene, 38814 Neighboring gene predicted gene, 33392 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations. Liu X, et al. Mucosal Immunol, 2022 Jun. PMID 36038770, Free PMC Article
  2. The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. Maekawa T, et al. Mol Cell Biol, 2010 Feb. PMID 19948881, Free PMC Article
  3. Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage. Desanlis I, et al. J Dev Biol, 2020 Dec 7. PMID 33297480, Free PMC Article
  4. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Lehoczky JA, et al. Evol Dev, 2004 Nov-Dec. PMID 15509224
  5. Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling. Paschaki M, et al. PLoS One, 2013. PMID 23638021, Free PMC Article

See all (28) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations.
    Title: Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations.
  2. TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
    Title: TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in white fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclic AMP-responsive element-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327821.1 → NP_001314750.1  cyclic AMP-responsive element-binding protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068064, AC068661, AC069141, AC079130, AK052451, BE943969
    Consensus CDS
    CCDS85049.1
    UniProtKB/Swiss-Prot
    Q8K1L0
    UniProtKB/TrEMBL
    A0A0N4SV71
    Related
    ENSMUSP00000144979.2, ENSMUST00000203528.3
    Conserved Domains (1) summary
    cd14687
    Location:370 → 429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  2. NM_172728.2 → NP_766316.1  cyclic AMP-responsive element-binding protein 5 isoform 2

    See identical proteins and their annotated locations for NP_766316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK052451
    Consensus CDS
    CCDS20153.1
    UniProtKB/Swiss-Prot
    Q8K1L0
    UniProtKB/TrEMBL
    A0A0N4SUK5
    Related
    ENSMUSP00000144719.2, ENSMUST00000205120.3
    Conserved Domains (1) summary
    cd14687
    Location:226 → 285
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    53264154..53677349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166039.1 → XP_036021932.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A0N4SUW5
    Related
    ENSMUSP00000144851.2, ENSMUST00000203487.3
    Conserved Domains (1) summary
    cd14687
    Location:377 → 436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  2. XM_036166040.1 → XP_036021933.1  cyclic AMP-responsive element-binding protein 5 isoform X2

    Conserved Domains (1) summary
    cd14687
    Location:377 → 436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  3. XM_036166042.1 → XP_036021935.1  cyclic AMP-responsive element-binding protein 5 isoform X5

  4. XM_036166041.1 → XP_036021934.1  cyclic AMP-responsive element-binding protein 5 isoform X3

    Conserved Domains (1) summary
    cd14687
    Location:226 → 285
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  5. XM_011241296.3 → XP_011239598.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    Conserved Domains (1) summary
    cd14687
    Location:148 → 207
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015553.2: Suppressed sequence

    Description
    NR_015553.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1L0.3 GenPept UniProtKB/Swiss-Prot:Q8K1L0

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