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Creb5 cAMP responsive element binding protein 5 [ Mus musculus (house mouse) ]

Gene ID: 231991, updated on 5-Mar-2024

Summary

Official Symbol
Creb5provided by MGI
Official Full Name
cAMP responsive element binding protein 5provided by MGI
Primary source
MGI:MGI:2443973
See related
Ensembl:ENSMUSG00000053007 AllianceGenome:MGI:2443973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crebpa; CRE-BPa; 9430076C15Rik; D430026C09Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in white fat cell differentiation. Acts upstream of or within adipose tissue development; fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including forelimb bud; hindlimb phalanx; limb mesenchyme; oral epithelium; and telencephalon ventricular layer. Orthologous to human CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 2.1), subcutaneous fat pad adult (RPKM 1.0) and 15 other tissues See more
Orthologs
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Genomic context

See Creb5 in Genome Data Viewer
Location:
6 B3; 6 25.9 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (53264154..53677349)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (53287226..53700364)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15922 Neighboring gene predicted gene 4872 Neighboring gene predicted gene, 33348 Neighboring gene STARR-seq mESC enhancer starr_15923 Neighboring gene STARR-seq mESC enhancer starr_15924 Neighboring gene predicted gene, 25818 Neighboring gene predicted gene, 38815 Neighboring gene predicted gene, 38814 Neighboring gene STARR-seq mESC enhancer starr_15926 Neighboring gene predicted gene, 33392 Neighboring gene STARR-seq mESC enhancer starr_15930 Neighboring gene STARR-seq mESC enhancer starr_15931 Neighboring gene STARR-seq mESC enhancer starr_15932 Neighboring gene STARR-seq mESC enhancer starr_15933 Neighboring gene predicted gene, 57762 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327821.1NP_001314750.1  cyclic AMP-responsive element-binding protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068064, AC068661, AC069141, AC079130, AK052451, BE943969
    Consensus CDS
    CCDS85049.1
    UniProtKB/TrEMBL
    A0A0N4SV71
    Related
    ENSMUSP00000144979.2, ENSMUST00000203528.3
    Conserved Domains (1) summary
    cd14687
    Location:370429
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  2. NM_172728.2NP_766316.1  cyclic AMP-responsive element-binding protein 5 isoform 2

    See identical proteins and their annotated locations for NP_766316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK052451
    Consensus CDS
    CCDS20153.1
    UniProtKB/Swiss-Prot
    Q3TCE1, Q3U228, Q8BWH8, Q8K1L0
    UniProtKB/TrEMBL
    A0A0N4SUK5
    Related
    ENSMUSP00000144719.2, ENSMUST00000205120.3
    Conserved Domains (1) summary
    cd14687
    Location:226285
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    53264154..53677349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166039.1XP_036021932.1  cyclic AMP-responsive element-binding protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A0N4SUW5
    Related
    ENSMUSP00000144851.2, ENSMUST00000203487.3
    Conserved Domains (1) summary
    cd14687
    Location:377436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  2. XM_036166040.1XP_036021933.1  cyclic AMP-responsive element-binding protein 5 isoform X2

    Conserved Domains (1) summary
    cd14687
    Location:377436
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  3. XM_036166042.1XP_036021935.1  cyclic AMP-responsive element-binding protein 5 isoform X5

  4. XM_036166041.1XP_036021934.1  cyclic AMP-responsive element-binding protein 5 isoform X3

    UniProtKB/Swiss-Prot
    Q3TCE1, Q3U228, Q8BWH8, Q8K1L0
    Conserved Domains (1) summary
    cd14687
    Location:226285
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
  5. XM_011241296.3XP_011239598.1  cyclic AMP-responsive element-binding protein 5 isoform X4

    Conserved Domains (1) summary
    cd14687
    Location:148207
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015553.2: Suppressed sequence

    Description
    NR_015553.2: This RefSeq was removed because currently there is insufficient support for the transcript.