atp9b ATPase phospholipid transporting 9B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp9bprovided by ZNC
Official Full Name: ATPase phospholipid transporting 9Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-583
See related: Ensembl:ENSDARG00000062521 AllianceGenome:ZFIN:ZDB-GENE-060503-583
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-198c22.1
Summary: Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within phospholipid transport. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (22074458..22180621)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (22490167..22594903)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled intramembrane lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled intramembrane lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable phospholipid-transporting ATPase IIB

Names: ATPase, class II, type 9B

NP_001038619.1

EC 7.6.2.1

XP_005170114.1

EC 7.6.2.1

XP_009292513.1

EC 7.6.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045154.1 → NP_001038619.1 probable phospholipid-transporting ATPase IIB

Status: PROVISIONAL

Source sequence(s)

BX855612

UniProtKB/TrEMBL

A0A2R8PZC8, A0A8M1NAD0

Related

ENSDARP00000145388.1, ENSDART00000185636.1

Conserved Domains (6) summary

cd01427
Location:713 → 863

HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

TIGR01652
Location:78 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:134 → 396

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:550 → 632

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:65 → 129

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:872 → 1100

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

22074458..22180621

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170057.4 → XP_005170114.1 probable phospholipid-transporting ATPase IIB isoform X1

UniProtKB/TrEMBL

A0A8M2BHD3

Conserved Domains (6) summary

cd01427
Location:730 → 880

HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

TIGR01652
Location:117 → 1134

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:173 → 413

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:567 → 649

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:104 → 168

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:889 → 1128

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
XM_009294238.3 → XP_009292513.1 probable phospholipid-transporting ATPase IIB isoform X2

See identical proteins and their annotated locations for XP_009292513.1

UniProtKB/Swiss-Prot

F1Q4S1

Conserved Domains (6) summary

cd01427
Location:730 → 880

HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...

TIGR01652
Location:117 → 1123

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:173 → 413

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:567 → 649

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:104 → 168

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:889 → 1117

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal