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ATP9B ATPase phospholipid transporting 9B (putative) [ Homo sapiens (human) ]

Gene ID: 374868, updated on 25-Nov-2021

Summary

Official Symbol
ATP9Bprovided by HGNC
Official Full Name
ATPase phospholipid transporting 9B (putative)provided by HGNC
Primary source
HGNC:HGNC:13541
See related
Ensembl:ENSG00000166377 MIM:614446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEO1L; hMMR1; ATPIIB; ATPASEP; HUSSY-20
Expression
Ubiquitous expression in testis (RPKM 2.8), thyroid (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See ATP9B in Genome Data Viewer
Location:
18q23
Exon count:
39
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (79069285..79378391)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (76829394..77138283)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372225 Neighboring gene spalt like transcription factor 3 Neighboring gene VISTA enhancer hs775 Neighboring gene uncharacterized LOC105372226 Neighboring gene histidine-rich protein PFHRP-II-like Neighboring gene uncharacterized LOC107985163 Neighboring gene nuclear factor of activated T cells 1 Neighboring gene uncharacterized LOC101927897

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATPase, class II, type 9B (ATP9B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46612, MGC61572, MGC150650, MGC150651, DKFZp686H2093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid translocation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable phospholipid-transporting ATPase IIB
Names
ATPase type IV, phospholipid transporting (P-type)
ATPase, class II, type 9B
macrophage MHC receptor 1
NP_001293014.1
NP_940933.3
XP_011524265.1
XP_011524266.1
XP_011524267.1
XP_011524268.1
XP_011524273.2
XP_011524274.1
XP_011524275.1
XP_011524276.1
XP_016881215.1
XP_016881216.1
XP_016881217.1
XP_016881218.1
XP_016881219.1
XP_016881220.1
XP_016881221.1
XP_016881222.1
XP_016881223.1
XP_016881224.1
XP_016881225.1
XP_016881226.1
XP_016881230.1
XP_016881231.1
XP_024306937.1
XP_024306938.1
XP_024306939.1
XP_024306940.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306085.2NP_001293014.1  probable phospholipid-transporting ATPase IIB isoform 2

    See identical proteins and their annotated locations for NP_001293014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL096735, AW411030, BC125219, HY028472
    Consensus CDS
    CCDS77202.1
    UniProtKB/Swiss-Prot
    O43861
    UniProtKB/TrEMBL
    Q69YZ7
    Related
    ENSP00000304500.7, ENST00000307671.12
    Conserved Domains (6) summary
    TIGR01652
    Location:1311131
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:223426
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:578660
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:124181
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:9001128
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:854895
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_198531.5NP_940933.3  probable phospholipid-transporting ATPase IIB isoform 1

    See identical proteins and their annotated locations for NP_940933.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK093704, AL096735, AW411030, BC022535, BC037546, BX537860, HY028472
    Consensus CDS
    CCDS12014.1
    UniProtKB/Swiss-Prot
    O43861
    UniProtKB/TrEMBL
    B3KSI8, Q69YZ7, Q7Z3J4
    Related
    ENSP00000398076.2, ENST00000426216.6
    Conserved Domains (6) summary
    TIGR01652
    Location:1311142
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:223426
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:578660
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:124181
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:9001139
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:854895
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. NR_148360.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023090, AC099689, AC104423, AC125437, AW411030

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    79069285..79378391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525963.2XP_011524265.1  probable phospholipid-transporting ATPase IIB isoform X1

    Conserved Domains (6) summary
    TIGR01652
    Location:1321169
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:224427
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:579661
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:125182
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:9271166
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:881922
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. XM_017025727.1XP_016881216.1  probable phospholipid-transporting ATPase IIB isoform X4

  3. XM_017025731.1XP_016881220.1  probable phospholipid-transporting ATPase IIB isoform X10

  4. XM_017025730.1XP_016881219.1  probable phospholipid-transporting ATPase IIB isoform X7

  5. XM_017025732.1XP_016881221.1  probable phospholipid-transporting ATPase IIB isoform X11

  6. XM_017025733.1XP_016881222.1  probable phospholipid-transporting ATPase IIB isoform X12

  7. XM_011525965.2XP_011524267.1  probable phospholipid-transporting ATPase IIB isoform X8

    See identical proteins and their annotated locations for XP_011524267.1

    Conserved Domains (6) summary
    TIGR01652
    Location:921129
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:184387
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:539621
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:85142
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8871126
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:841882
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  8. XM_017025728.2XP_016881217.1  probable phospholipid-transporting ATPase IIB isoform X5

  9. XM_017025726.1XP_016881215.1  probable phospholipid-transporting ATPase IIB isoform X3

  10. XM_017025729.1XP_016881218.1  probable phospholipid-transporting ATPase IIB isoform X6

  11. XM_017025736.2XP_016881225.1  probable phospholipid-transporting ATPase IIB isoform X15

  12. XM_017025735.2XP_016881224.1  probable phospholipid-transporting ATPase IIB isoform X14

  13. XM_017025734.1XP_016881223.1  probable phospholipid-transporting ATPase IIB isoform X13

  14. XM_017025737.1XP_016881226.1  probable phospholipid-transporting ATPase IIB isoform X16

  15. XM_017025742.1XP_016881231.1  probable phospholipid-transporting ATPase IIB isoform X24

  16. XM_011525964.2XP_011524266.1  probable phospholipid-transporting ATPase IIB isoform X2

    Conserved Domains (6) summary
    TIGR01652
    Location:1311168
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:223426
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:578660
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:124181
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:9261165
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:880921
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  17. XM_024451170.1XP_024306938.1  probable phospholipid-transporting ATPase IIB isoform X22

    Conserved Domains (2) summary
    cl21460
    Location:1662
    HAD_like; Haloacid Dehalogenase-like Hydrolases
    cl26237
    Location:182266
    Cation_ATPase; Cation transport ATPase (P-type)
  18. XM_024451169.1XP_024306937.1  probable phospholipid-transporting ATPase IIB isoform X21

    Conserved Domains (2) summary
    cl21460
    Location:1750
    HAD_like; Haloacid Dehalogenase-like Hydrolases
    cl26237
    Location:270354
    Cation_ATPase; Cation transport ATPase (P-type)
  19. XM_024451172.1XP_024306940.1  probable phospholipid-transporting ATPase IIB isoform X22

    Conserved Domains (2) summary
    cl21460
    Location:1662
    HAD_like; Haloacid Dehalogenase-like Hydrolases
    cl26237
    Location:182266
    Cation_ATPase; Cation transport ATPase (P-type)
  20. XM_024451171.1XP_024306939.1  probable phospholipid-transporting ATPase IIB isoform X22

    Conserved Domains (2) summary
    cl21460
    Location:1662
    HAD_like; Haloacid Dehalogenase-like Hydrolases
    cl26237
    Location:182266
    Cation_ATPase; Cation transport ATPase (P-type)
  21. XM_017025741.2XP_016881230.1  probable phospholipid-transporting ATPase IIB isoform X23

    Conserved Domains (4) summary
    TIGR01652
    Location:10739
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:149231
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:497736
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:451492
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  22. XM_011525966.2XP_011524268.1  probable phospholipid-transporting ATPase IIB isoform X9

    See identical proteins and their annotated locations for XP_011524268.1

    Conserved Domains (6) summary
    TIGR01652
    Location:921129
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:184387
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:539621
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:85142
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8871126
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:841882
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  23. XM_011525972.2XP_011524274.1  probable phospholipid-transporting ATPase IIB isoform X18

    Conserved Domains (4) summary
    pfam00122
    Location:78177
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:329411
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:677916
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:631672
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  24. XM_011525974.2XP_011524276.1  probable phospholipid-transporting ATPase IIB isoform X20

    Conserved Domains (4) summary
    pfam00122
    Location:21120
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:272354
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:620859
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:574615
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  25. XM_011525971.2XP_011524273.2  probable phospholipid-transporting ATPase IIB isoform X17

  26. XM_011525973.2XP_011524275.1  probable phospholipid-transporting ATPase IIB isoform X19

    Conserved Domains (4) summary
    pfam00122
    Location:37136
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:288370
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:636875
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:590631
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

  1. XR_001753193.1 RNA Sequence

  2. XR_001753194.1 RNA Sequence

  3. XR_001753192.1 RNA Sequence

  4. XR_001753198.1 RNA Sequence

  5. XR_002958169.1 RNA Sequence

  6. XR_002958170.1 RNA Sequence

  7. XR_001753195.2 RNA Sequence

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