|
| Status |
Public on Mar 01, 2016 |
| Title |
DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across 485,577 CpGs . Samples were restored FFPE DNA extracted from breast tumours in 3 groups; BRCA1 germline mutated tumours (BRCA1), BRCA1 germline wildtype tumours from women from high risk families (BRCAx) and the designated test variant tumours (BRCA1UV).
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| |
|
| Overall design |
Bisulphite converted DNA was hybridised to the Illumina Infinium 450k Human Methylation Beadchip
|
| |
|
| Contributor(s) |
Flanagan JM, Flower KJ |
| Citation(s) |
26727311 |
| Submission date |
Aug 22, 2015 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Kirsty J Flower |
| E-mail(s) |
k.flower@imperial.ac.uk
|
| Organization name |
Imperial College London
|
| Street address |
Du Cane Road
|
| City |
London |
| ZIP/Postal code |
W12 0HS |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
|
| Samples (60)
|
|
| Relations |
| BioProject |
PRJNA293616 |
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