GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE163970 Query DataSets for GSE163970
Status Public on Jun 03, 2021
Title Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary This study demonstrated that PDB has an epigenetic signature in the blood and that differentially methylated sites in white blood cells may be used as predictive markers of the disease. Many of the identified changes in DNA methylation were associated with genes that regulate osteoclast function, immune responses, host reponse to viral infection, pain pathways and pathways involved in mechanosensing.
Overall design The study was conducted in 253 cases with clinical and radiological evidence of PDB and 280 controls who were spouses of PDB cases (n=135) or subjects who had been referred for investigation of osteoporosis but had normal bone density upon examination by dual energy X-ray absorptiometry (n=131)
Contributor(s) Albagha OM, Diboun I, Ralston SH, Wani S
Citation(s) 33929316
Submission date Dec 29, 2020
Last update date Apr 22, 2022
Contact name Omar M E Albagha
Organization name Hamad Bin Khalifa University
Department Health and Life Sciences
Street address Luqta Street, Education City
City Doha
ZIP/Postal code P.O. Box: 34110
Country Qatar
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (492)
GSM4991578 PRISM_PDB_21Case
GSM4991579 PRISM_PDB_178Case
GSM4991580 PRISM_PDB_349Case
BioProject PRJNA688467

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE163970_M-processed-methylationData.txt.gz 1.6 Gb (ftp)(http) TXT
GSE163970_RAW.tar 4.1 Gb (http)(custom) TAR (of IDAT)
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap