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| Status |
Public on Jun 03, 2021 |
| Title |
Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
This study demonstrated that PDB has an epigenetic signature in the blood and that differentially methylated sites in white blood cells may be used as predictive markers of the disease. Many of the identified changes in DNA methylation were associated with genes that regulate osteoclast function, immune responses, host reponse to viral infection, pain pathways and pathways involved in mechanosensing.
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| Overall design |
The study was conducted in 253 cases with clinical and radiological evidence of PDB and 280 controls who were spouses of PDB cases (n=135) or subjects who had been referred for investigation of osteoporosis but had normal bone density upon examination by dual energy X-ray absorptiometry (n=131)
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| Contributor(s) |
Albagha OM, Diboun I, Ralston SH, Wani S |
| Citation(s) |
33929316 |
| |
| Submission date |
Dec 29, 2020 |
| Last update date |
Apr 22, 2022 |
| Contact name |
Omar M E Albagha |
| E-mail(s) |
oalbagha@hbku.edu.qa
|
| Organization name |
Hamad Bin Khalifa University
|
| Department |
Health and Life Sciences
|
| Street address |
Luqta Street, Education City
|
| City |
Doha |
| ZIP/Postal code |
P.O. Box: 34110 |
| Country |
Qatar |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (492)
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| Relations |
| BioProject |
PRJNA688467 |
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