|
| Status |
Public on Nov 30, 2020 |
| Title |
Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity (DNA methylation data set) |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
We show that Glioma initiating cells (GICs) can, through MES transition, enter a reactive-astrocyte-like cell state which is connected to increased therapy resistance
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| |
|
| Overall design |
Illumina Infinium Methylation EPIC array analyses were performed according to the manufacturer's directions on genomic DNA extracted from clonal malignant glioma cells in time series of IL1 stimulation (1-42 days) and corresponding control cells.
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| |
|
| Contributor(s) |
Segerman B, Segerman A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 21, 2018 |
| Last update date |
Dec 03, 2020 |
| Contact name |
Bo Segerman |
| E-mail(s) |
bo.segerman@igp.uu.se
|
| Organization name |
Uppsala University
|
| Street address |
Dag Hammarskjolds v 20
|
| City |
Uppsala |
| ZIP/Postal code |
751 85 |
| Country |
Sweden |
| |
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| Platforms (1) |
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| Samples (14)
|
| GSM3485850 |
RA2_271_CTL_11d: Malignant glioma clone U3065MG-C271 11 days control, replicate serie 1 |
| GSM3485851 |
RA2_271_IL1b_11d: Malignant glioma clone U3065MG-C271 11 days IL1beta stimulation, replicate serie 1 |
| GSM3485852 |
RA2_271_CTL_21d: Malignant glioma clone U3065MG-C271 21 days control, replicate serie 1 |
| GSM3485853 |
RA2_271_IL1b_21d: Malignant glioma clone U3065MG-C271 21 days IL1beta stimulation, replicate serie 1 |
| GSM3485854 |
RA4_271_CTL_42d: Malignant glioma clone U3065MG-C271 42 days control, replicate serie 2 |
| GSM3485855 |
RA4_271_IL1b_42d: Malignant glioma clone U3065MG-C271 42 days IL1beta stimulation, replicate serie 2 |
| GSM3485856 |
RA2_271_CTL_28d: Malignant glioma clone U3065MG-C271 28 days control, replicate serie 1 |
| GSM3485857 |
RA2_271_IL1b_28d: Malignant glioma clone U3065MG-C271 28 days IL1beta stimulation, replicate serie 1 |
| GSM3485858 |
RA2_271_CTL_34d: Malignant glioma clone U3065MG-C271 34 days control, replicate serie 1 |
| GSM3485859 |
RA2_271_IL1b_34d: Malignant glioma clone U3065MG-C271 34 days IL1beta stimulation, replicate serie 1 |
| GSM3485860 |
RA4_271_CTL_13d: Malignant glioma clone U3065MG-C271 13 days control, replicate serie 2 |
| GSM3485861 |
RA4_271_IL1b_13d: Malignant glioma clone U3065MG-C271 13 days IL1beta stimulation, replicate serie 2 |
| GSM3485862 |
RA4_271_CTL_27d: Malignant glioma clone U3065MG-C271 27 days control, replicate serie 2 |
| GSM3485863 |
RA4_271_IL1b_27d: Malignant glioma clone U3065MG-C271 27 days IL1beta stimulation, replicate serie 2 |
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| This SubSeries is part of SuperSeries: |
| GSE122809 |
Mesenchymal transition and acquired therapy resistance of glioblastoma cells is connected to astrocyte reactivity |
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| Relations |
| BioProject |
PRJNA506417 |
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