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    PIAS2 protein inhibitor of activated STAT 2 [ Homo sapiens (human) ]

    Gene ID: 9063, updated on 17-Jun-2019

    Summary

    Official Symbol
    PIAS2provided by HGNC
    Official Full Name
    protein inhibitor of activated STAT 2provided by HGNC
    Primary source
    HGNC:HGNC:17311
    See related
    Ensembl:ENSG00000078043 MIM:603567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4
    Summary
    This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
    Expression
    Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more
    Orthologs

    Genomic context

    See PIAS2 in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (46803218..46920167, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44388900..44500130, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene ribosomal protein S21 pseudogene 6 Neighboring gene uncharacterized LOC105372097 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene elongin A3 family member D Neighboring gene elongin A3 family member C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Activation of HOX genes during differentiation, organism-specific biosystem (from REACTOME)
      Activation of HOX genes during differentiation, organism-specific biosystemHox genes encode proteins that contain the DNA-binding homeobox motif and control early patterning of segments in the embryo as well as later events in development (reviewed in Rezsohazy et al. 2015)...
    • Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystem (from REACTOME)
      Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystemIn mammals, anterior Hox genes may be defined as paralog groups 1 to 4 (Natale et al. 2011), which are involved in development of the hindbrain through sequential expression in the rhombomeres, trans...
    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
      IL12 signaling mediated by STAT4, organism-specific biosystem
      IL12 signaling mediated by STAT4
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
      SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
      Sumoylation by RanBP2 regulates transcriptional repression
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102682

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS2
    Names
    DAB2-interacting protein
    E3 SUMO-protein transferase PIAS2
    androgen receptor-interacting protein 3
    msx-interacting zinc finger protein
    protein inhibitor of activated STAT X
    zinc finger, MIZ-type containing 4
    NP_001310975.1
    NP_001310976.1
    NP_001310977.1
    NP_001310978.1
    NP_001310980.1
    NP_001310981.1
    NP_001310982.1
    NP_001310983.1
    NP_001310984.1
    NP_001310986.1
    NP_001310987.1
    NP_001310988.1
    NP_001310989.1
    NP_001340962.1
    NP_001340963.1
    NP_001340964.1
    NP_001340965.1
    NP_001340966.1
    NP_001340967.1
    NP_001340968.1
    NP_004662.2
    NP_775298.1
    XP_005258434.1
    XP_006722634.1
    XP_006722635.1
    XP_006722636.1
    XP_011524560.1
    XP_016881561.1
    XP_024307050.1
    XP_024307051.1
    XP_024307052.1
    XP_024307053.1
    XP_024307054.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029865.2 RefSeqGene

      Range
      5001..119309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001324046.2NP_001310975.1  E3 SUMO-protein ligase PIAS2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    2. NM_001324047.2NP_001310976.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    3. NM_001324048.2NP_001310977.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A024RC49
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    4. NM_001324049.2NP_001310978.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A024RC49
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    5. NM_001324051.2NP_001310980.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    6. NM_001324052.2NP_001310981.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    7. NM_001324053.2NP_001310982.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    8. NM_001324054.2NP_001310983.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    9. NM_001324055.2NP_001310984.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    10. NM_001324057.2NP_001310986.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    11. NM_001324058.2NP_001310987.1  E3 SUMO-protein ligase PIAS2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, BC111060
      UniProtKB/TrEMBL
      Q2TA77
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:342390
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:145282
      PINIT; PINIT domain
    12. NM_001324059.2NP_001310988.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Related
      ENSP00000479025.1, ENST00000592212.5
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    13. NM_001324060.2NP_001310989.1  E3 SUMO-protein ligase PIAS2 isoform NY

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform NY from PMID: 15301740.
      Source sequence(s)
      AC090241, AF361054
      UniProtKB/Swiss-Prot
      O75928
    14. NM_001354033.2NP_001340962.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    15. NM_001354034.2NP_001340963.1  E3 SUMO-protein ligase PIAS2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:147291
      PINIT; PINIT domain
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    16. NM_001354035.2NP_001340964.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    17. NM_001354036.2NP_001340965.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    18. NM_001354037.2NP_001340966.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    19. NM_001354038.2NP_001340967.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    20. NM_001354039.2NP_001340968.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    21. NM_004671.5NP_004662.2  E3 SUMO-protein ligase PIAS2 isoform beta

      See identical proteins and their annotated locations for NP_004662.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) encodes isoform (beta).
      Source sequence(s)
      AC090241, AF077954, AF086240, BG718291
      Consensus CDS
      CCDS32824.1
      UniProtKB/Swiss-Prot
      O75928
      Related
      ENSP00000465676.1, ENST00000585916.6
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:147291
      PINIT; PINIT domain
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    22. NM_173206.4NP_775298.1  E3 SUMO-protein ligase PIAS2 isoform alpha

      See identical proteins and their annotated locations for NP_775298.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) utilizes an alternate 3' coding exon, compared to variant beta, resulting in a shorter isoform (alpha) that has a unique C-terminus compared to isoform beta.
      Source sequence(s)
      AC090241, BC015190, BG718291
      Consensus CDS
      CCDS32825.1
      UniProtKB/Swiss-Prot
      O75928
      Related
      ENSP00000317163.6, ENST00000324794.11
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:147291
      PINIT; PINIT domain
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    RNA

    1. NR_136684.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, AF086240, AK308143
    2. NR_136685.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, AK294801
    3. NR_148699.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    4. NR_148700.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    5. NR_148701.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    6. NR_148702.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    7. NR_148703.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

      Range
      46803218..46920167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451283.1XP_024307051.1  E3 SUMO-protein ligase PIAS2 isoform X8

      Conserved Domains (3) summary
      smart00513
      Location:5084
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:186330
      PINIT; PINIT domain
      cd16790
      Location:382429
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    2. XM_024451284.1XP_024307052.1  E3 SUMO-protein ligase PIAS2 isoform X8

      Conserved Domains (3) summary
      smart00513
      Location:5084
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:186330
      PINIT; PINIT domain
      cd16790
      Location:382429
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    3. XM_006722571.3XP_006722634.1  E3 SUMO-protein ligase PIAS2 isoform X1

      Conserved Domains (3) summary
      smart00513
      Location:5084
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:381429
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:184321
      PINIT; PINIT domain
    4. XM_024451285.1XP_024307053.1  E3 SUMO-protein ligase PIAS2 isoform X9

      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:147291
      PINIT; PINIT domain
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    5. XM_024451286.1XP_024307054.1  E3 SUMO-protein ligase PIAS2 isoform X10

      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    6. XM_005258377.3XP_005258434.1  E3 SUMO-protein ligase PIAS2 isoform X3

      See identical proteins and their annotated locations for XP_005258434.1

      Conserved Domains (3) summary
      smart00513
      Location:1549
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:346394
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:149286
      PINIT; PINIT domain
    7. XM_006722572.3XP_006722635.1  E3 SUMO-protein ligase PIAS2 isoform X2

      Conserved Domains (3) summary
      smart00513
      Location:5084
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:381429
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:184321
      PINIT; PINIT domain
    8. XM_024451282.1XP_024307050.1  E3 SUMO-protein ligase PIAS2 isoform X5

      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    9. XM_011526258.2XP_011524560.1  E3 SUMO-protein ligase PIAS2 isoform X4

      Conserved Domains (3) summary
      smart00513
      Location:943
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:145289
      PINIT; PINIT domain
      cd16790
      Location:341388
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    10. XM_006722573.2XP_006722636.1  E3 SUMO-protein ligase PIAS2 isoform X6

      Conserved Domains (3) summary
      smart00513
      Location:5084
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:381429
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:184321
      PINIT; PINIT domain
    11. XM_017026072.1XP_016881561.1  E3 SUMO-protein ligase PIAS2 isoform X7

      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

    RNA

    1. XR_001753298.1 RNA Sequence

    2. XR_001753300.1 RNA Sequence

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