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    PIAS2 protein inhibitor of activated STAT 2 [ Homo sapiens (human) ]

    Gene ID: 9063, updated on 1-Mar-2024

    Summary

    Official Symbol
    PIAS2provided by HGNC
    Official Full Name
    protein inhibitor of activated STAT 2provided by HGNC
    Primary source
    HGNC:HGNC:17311
    See related
    Ensembl:ENSG00000078043 MIM:603567; AllianceGenome:HGNC:17311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4
    Summary
    This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
    Expression
    Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PIAS2 in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (46803218..46920145, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (46993864..47110811, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44383181..44500108, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene ribosomal protein S21 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9420 Neighboring gene ST8SIA5 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr18:44374579-44375080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13281 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13282 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:44447848-44449047 Neighboring gene uncharacterized LOC124904294 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:44479065-44479890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44490867-44491368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44491369-44491868 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:44496866-44497619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44499127-44499879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9423 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44546997-44547496 Neighboring gene elongin A3 family member D, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44552405-44553168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:44553169-44553932 Neighboring gene elongin A3 family member B, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102682

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS2
    Names
    DAB2-interacting protein
    E3 SUMO-protein transferase PIAS2
    androgen receptor-interacting protein 3
    msx-interacting zinc finger protein
    protein inhibitor of activated STAT X
    zinc finger, MIZ-type containing 4
    NP_001310975.1
    NP_001310976.1
    NP_001310977.1
    NP_001310978.1
    NP_001310980.1
    NP_001310981.1
    NP_001310982.1
    NP_001310983.1
    NP_001310984.1
    NP_001310986.1
    NP_001310987.1
    NP_001310988.1
    NP_001310989.1
    NP_001340962.1
    NP_001340963.1
    NP_001340964.1
    NP_001340965.1
    NP_001340966.1
    NP_001340967.1
    NP_001340968.1
    NP_004662.2
    NP_775298.1
    XP_006722636.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029865.2 RefSeqGene

      Range
      5026..119315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001324046.2NP_001310975.1  E3 SUMO-protein ligase PIAS2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138282
      PINIT; PINIT domain
    2. NM_001324047.2NP_001310976.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    3. NM_001324048.2NP_001310977.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138282
      PINIT; PINIT domain
    4. NM_001324049.2NP_001310978.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138282
      PINIT; PINIT domain
    5. NM_001324051.2NP_001310980.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    6. NM_001324052.2NP_001310981.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    7. NM_001324053.2NP_001310982.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    8. NM_001324054.2NP_001310983.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    9. NM_001324055.2NP_001310984.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    10. NM_001324057.2NP_001310986.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    11. NM_001324058.2NP_001310987.1  E3 SUMO-protein ligase PIAS2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, BC111060
      UniProtKB/TrEMBL
      A0A087WUY7, Q2TA77
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:342390
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:145282
      PINIT; PINIT domain
    12. NM_001324059.2NP_001310988.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Related
      ENSP00000479025.1, ENST00000592212.5
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    13. NM_001324060.2NP_001310989.1  E3 SUMO-protein ligase PIAS2 isoform NY

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform NY from PMID: 15301740.
      Source sequence(s)
      AC090241, AF361054
      UniProtKB/Swiss-Prot
      O75928
      Related
      ENST00000592011.5
    14. NM_001354033.2NP_001340962.1  E3 SUMO-protein ligase PIAS2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    15. NM_001354034.2NP_001340963.1  E3 SUMO-protein ligase PIAS2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147296
      PINIT; PINIT domain
    16. NM_001354035.2NP_001340964.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138282
      PINIT; PINIT domain
    17. NM_001354036.2NP_001340965.1  E3 SUMO-protein ligase PIAS2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138282
      PINIT; PINIT domain
    18. NM_001354037.2NP_001340966.1  E3 SUMO-protein ligase PIAS2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14324
      Location:138282
      PINIT; PINIT domain
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    19. NM_001354038.2NP_001340967.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    20. NM_001354039.2NP_001340968.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:236
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:334381
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:138287
      PINIT; PINIT domain
    21. NM_004671.5NP_004662.2  E3 SUMO-protein ligase PIAS2 isoform beta

      See identical proteins and their annotated locations for NP_004662.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) encodes isoform (beta).
      Source sequence(s)
      AC090241, AF077954, AF086240, BG718291
      Consensus CDS
      CCDS32824.1
      UniProtKB/Swiss-Prot
      O75927, O75928, Q96BT5, Q96KE3
      Related
      ENSP00000465676.1, ENST00000585916.6
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147296
      PINIT; PINIT domain
    22. NM_173206.4NP_775298.1  E3 SUMO-protein ligase PIAS2 isoform alpha

      See identical proteins and their annotated locations for NP_775298.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) utilizes an alternate 3' coding exon, compared to variant beta, resulting in a shorter isoform (alpha) that has a unique C-terminus compared to isoform beta.
      Source sequence(s)
      AC090241, BC015190, BG718291
      Consensus CDS
      CCDS32825.1
      UniProtKB/TrEMBL
      A0A087WUY7
      Related
      ENSP00000317163.6, ENST00000324794.11
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147296
      PINIT; PINIT domain

    RNA

    1. NR_136684.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, AF086240, AK308143
    2. NR_136685.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373, AK294801
    3. NR_148699.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    4. NR_148700.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    5. NR_148701.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    6. NR_148702.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373
    7. NR_148703.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC090241, AC090373

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      46803218..46920145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722573.3XP_006722636.1  E3 SUMO-protein ligase PIAS2 isoform X1

      UniProtKB/TrEMBL
      A0A087WUY7
      Conserved Domains (3) summary
      smart00513
      Location:5084
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:381429
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:184321
      PINIT; PINIT domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      46993864..47110811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)