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Pias2 protein inhibitor of activated STAT 2 [ Mus musculus (house mouse) ]

Gene ID: 17344, updated on 1-Mar-2024

Summary

Official Symbol
Pias2provided by MGI
Official Full Name
protein inhibitor of activated STAT 2provided by MGI
Primary source
MGI:MGI:1096566
See related
Ensembl:ENSMUSG00000025423 AllianceGenome:MGI:1096566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIP; Dib; Miz1; SIZ2; ARIP3; PIASxb; PIASxbeta; PIASxalpha; PIASxalpha6
Summary
Enables DNA binding activity; SUMO transferase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including protein sumoylation; regulation of osteoblast differentiation; and transcription, DNA-templated. Located in nuclear body. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 36.6), CNS E14 (RPKM 8.7) and 22 other tissues See more
Orthologs
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Genomic context

See Pias2 in Genome Data Viewer
Location:
18 E3; 18 52.07 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77152883..77243406)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77065176..77155710)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene katanin p60 subunit A-like 2 Neighboring gene STARR-seq mESC enhancer starr_45107 Neighboring gene STARR-positive B cell enhancer mm9_chr18:77285922-77286223 Neighboring gene RIKEN cDNA 4930520E11 gene Neighboring gene STARR-seq mESC enhancer starr_45110 Neighboring gene STARR-seq mESC enhancer starr_45112 Neighboring gene STARR-seq mESC enhancer starr_45115 Neighboring gene predicted gene 7276 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_45117 Neighboring gene lipoxygenase homology domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
enables SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS2
Names
DAB2-interacting protein
Msx-interacting-zinc finger
RING-type E3 ubiquitin transferase PIAS2
androgen receptor-interacting protein 3
msx-interacting zinc finger protein
protein inhibitor of activated STAT x
NP_001157639.1
NP_001157640.1
NP_001157641.1
NP_001157642.1
NP_032628.3
XP_006526486.1
XP_006526488.1
XP_036016910.1
XP_036016911.1
XP_036016912.1
XP_036016913.1
XP_036016914.1
XP_036016916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164167.1NP_001157639.1  E3 SUMO-protein ligase PIAS2 isoform 2

    See identical proteins and their annotated locations for NP_001157639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a frameshift and distinct C-terminus in isoform 2, compared to isoform 1.
    Source sequence(s)
    AK029716, AK032463, AK086653
    UniProtKB/Swiss-Prot
    Q8C5D8
    UniProtKB/TrEMBL
    Q3V3U5
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:342390
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:145282
    PINIT; PINIT domain
  2. NM_001164168.1NP_001157640.1  E3 SUMO-protein ligase PIAS2 isoform 3

    See identical proteins and their annotated locations for NP_001157640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 3 has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK032463, AK086653, BU704371
    Consensus CDS
    CCDS50324.1
    UniProtKB/TrEMBL
    G3UWE3
    Related
    ENSMUSP00000131485.2, ENSMUST00000168882.9
    Conserved Domains (3) summary
    smart00513
    Location:438
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:335383
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:138275
    PINIT; PINIT domain
  3. NM_001164169.1NP_001157641.1  E3 SUMO-protein ligase PIAS2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, resulting in a translational frameshift, compared to variant 1. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC157991, AK014871, AK029716
    UniProtKB/Swiss-Prot
    Q8C5D8
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:342390
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:145282
    PINIT; PINIT domain
  4. NM_001164170.1NP_001157642.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 5) has a distinct N- and C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC157991, AK014871, AK086653, BU704371
    Consensus CDS
    CCDS50323.1
    UniProtKB/TrEMBL
    F8WHS8
    Related
    ENSMUSP00000110424.3, ENSMUST00000114776.4
    Conserved Domains (3) summary
    smart00513
    Location:438
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:335383
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:138275
    PINIT; PINIT domain
  5. NM_008602.4NP_032628.3  E3 SUMO-protein ligase PIAS2 isoform 1

    See identical proteins and their annotated locations for NP_032628.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC157991, AK029716, AK032463
    Consensus CDS
    CCDS37866.1
    UniProtKB/Swiss-Prot
    O54987, Q8C384, Q8C5D8, Q8CDQ8, Q8K208, Q99JX5, Q9D5W7, Q9QZ63
    Related
    ENSMUSP00000110425.3, ENSMUST00000114777.10
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:342390
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:145282
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77152883..77243406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526423.4XP_006526486.1  E3 SUMO-protein ligase PIAS2 isoform X1

    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147291
    PINIT; PINIT domain
  2. XM_036161018.1XP_036016911.1  E3 SUMO-protein ligase PIAS2 isoform X4

    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147296
    PINIT; PINIT domain
  3. XM_036161019.1XP_036016912.1  E3 SUMO-protein ligase PIAS2 isoform X4

    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147296
    PINIT; PINIT domain
  4. XM_036161020.1XP_036016913.1  E3 SUMO-protein ligase PIAS2 isoform X4

    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147296
    PINIT; PINIT domain
  5. XM_006526425.4XP_006526488.1  E3 SUMO-protein ligase PIAS2 isoform X2

    Conserved Domains (3) summary
    smart00513
    Location:438
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:336383
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:140284
    PINIT; PINIT domain
  6. XM_036161017.1XP_036016910.1  E3 SUMO-protein ligase PIAS2 isoform X3

    Conserved Domains (3) summary
    smart00513
    Location:438
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:336383
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:140289
    PINIT; PINIT domain
  7. XM_036161021.1XP_036016914.1  E3 SUMO-protein ligase PIAS2 isoform X5

    Conserved Domains (3) summary
    smart00513
    Location:438
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:336383
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:140289
    PINIT; PINIT domain
  8. XM_036161023.1XP_036016916.1  E3 SUMO-protein ligase PIAS2 isoform X5

    Conserved Domains (3) summary
    smart00513
    Location:438
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:336383
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:140289
    PINIT; PINIT domain

RNA

  1. XR_001782348.3 RNA Sequence

  2. XR_001782349.3 RNA Sequence