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PIAS2 protein inhibitor of activated STAT 2 [ Homo sapiens (human) ]

Gene ID: 9063, updated on 20-Mar-2020

Summary

Official Symbol
PIAS2provided by HGNC
Official Full Name
protein inhibitor of activated STAT 2provided by HGNC
Primary source
HGNC:HGNC:17311
See related
Ensembl:ENSG00000078043 MIM:603567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4
Summary
This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
Expression
Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more
Orthologs

Genomic context

See PIAS2 in Genome Data Viewer
Location:
18q21.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (46803218..46920167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44388900..44500130, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene ribosomal protein S21 pseudogene 6 Neighboring gene uncharacterized LOC105372097 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene elongin A3 family member D Neighboring gene elongin A3 family member C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS2
Names
DAB2-interacting protein
E3 SUMO-protein transferase PIAS2
androgen receptor-interacting protein 3
msx-interacting zinc finger protein
protein inhibitor of activated STAT X
zinc finger, MIZ-type containing 4
NP_001310975.1
NP_001310976.1
NP_001310977.1
NP_001310978.1
NP_001310980.1
NP_001310981.1
NP_001310982.1
NP_001310983.1
NP_001310984.1
NP_001310986.1
NP_001310987.1
NP_001310988.1
NP_001310989.1
NP_001340962.1
NP_001340963.1
NP_001340964.1
NP_001340965.1
NP_001340966.1
NP_001340967.1
NP_001340968.1
NP_004662.2
NP_775298.1
XP_005258434.1
XP_006722634.1
XP_006722635.1
XP_006722636.1
XP_011524560.1
XP_016881561.1
XP_024307050.1
XP_024307051.1
XP_024307052.1
XP_024307053.1
XP_024307054.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029865.2 RefSeqGene

    Range
    5026..119315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324046.2NP_001310975.1  E3 SUMO-protein ligase PIAS2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  2. NM_001324047.2NP_001310976.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  3. NM_001324048.2NP_001310977.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A024RC49
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  4. NM_001324049.2NP_001310978.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A024RC49
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  5. NM_001324051.2NP_001310980.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  6. NM_001324052.2NP_001310981.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  7. NM_001324053.2NP_001310982.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  8. NM_001324054.2NP_001310983.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  9. NM_001324055.2NP_001310984.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  10. NM_001324057.2NP_001310986.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  11. NM_001324058.2NP_001310987.1  E3 SUMO-protein ligase PIAS2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, BC111060
    UniProtKB/TrEMBL
    Q2TA77
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:342390
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:145282
    PINIT; PINIT domain
  12. NM_001324059.2NP_001310988.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Related
    ENSP00000479025.1, ENST00000592212.5
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  13. NM_001324060.2NP_001310989.1  E3 SUMO-protein ligase PIAS2 isoform NY

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform NY from PMID: 15301740.
    Source sequence(s)
    AC090241, AF361054
    UniProtKB/Swiss-Prot
    O75928
    Related
    ENST00000592011.5
  14. NM_001354033.2NP_001340962.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  15. NM_001354034.2NP_001340963.1  E3 SUMO-protein ligase PIAS2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  16. NM_001354035.2NP_001340964.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  17. NM_001354036.2NP_001340965.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  18. NM_001354037.2NP_001340966.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  19. NM_001354038.2NP_001340967.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  20. NM_001354039.2NP_001340968.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  21. NM_004671.5NP_004662.2  E3 SUMO-protein ligase PIAS2 isoform beta

    See identical proteins and their annotated locations for NP_004662.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) encodes isoform (beta).
    Source sequence(s)
    AC090241, AF077954, AF086240, BG718291
    Consensus CDS
    CCDS32824.1
    UniProtKB/Swiss-Prot
    O75928
    Related
    ENSP00000465676.1, ENST00000585916.6
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  22. NM_173206.4NP_775298.1  E3 SUMO-protein ligase PIAS2 isoform alpha

    See identical proteins and their annotated locations for NP_775298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) utilizes an alternate 3' coding exon, compared to variant beta, resulting in a shorter isoform (alpha) that has a unique C-terminus compared to isoform beta.
    Source sequence(s)
    AC090241, BC015190, BG718291
    Consensus CDS
    CCDS32825.1
    UniProtKB/Swiss-Prot
    O75928
    Related
    ENSP00000317163.6, ENST00000324794.11
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

RNA

  1. NR_136684.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, AF086240, AK308143
  2. NR_136685.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, AK294801
  3. NR_148699.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  4. NR_148700.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  5. NR_148701.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  6. NR_148702.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  7. NR_148703.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    46803218..46920167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451283.1XP_024307051.1  E3 SUMO-protein ligase PIAS2 isoform X8

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:186330
    PINIT; PINIT domain
    cd16790
    Location:382429
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  2. XM_024451284.1XP_024307052.1  E3 SUMO-protein ligase PIAS2 isoform X8

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:186330
    PINIT; PINIT domain
    cd16790
    Location:382429
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  3. XM_006722571.3XP_006722634.1  E3 SUMO-protein ligase PIAS2 isoform X1

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:381429
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:184321
    PINIT; PINIT domain
  4. XM_024451285.1XP_024307053.1  E3 SUMO-protein ligase PIAS2 isoform X9

    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  5. XM_024451286.1XP_024307054.1  E3 SUMO-protein ligase PIAS2 isoform X10

    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  6. XM_005258377.3XP_005258434.1  E3 SUMO-protein ligase PIAS2 isoform X3

    See identical proteins and their annotated locations for XP_005258434.1

    Conserved Domains (3) summary
    smart00513
    Location:1549
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:346394
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:149286
    PINIT; PINIT domain
  7. XM_006722572.3XP_006722635.1  E3 SUMO-protein ligase PIAS2 isoform X2

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:381429
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:184321
    PINIT; PINIT domain
  8. XM_024451282.1XP_024307050.1  E3 SUMO-protein ligase PIAS2 isoform X5

    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  9. XM_011526258.2XP_011524560.1  E3 SUMO-protein ligase PIAS2 isoform X4

    Conserved Domains (3) summary
    smart00513
    Location:943
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:145289
    PINIT; PINIT domain
    cd16790
    Location:341388
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  10. XM_006722573.2XP_006722636.1  E3 SUMO-protein ligase PIAS2 isoform X6

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:381429
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:184321
    PINIT; PINIT domain
  11. XM_017026072.1XP_016881561.1  E3 SUMO-protein ligase PIAS2 isoform X7

    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

RNA

  1. XR_001753298.1 RNA Sequence

  2. XR_001753300.1 RNA Sequence

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