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PIAS2 protein inhibitor of activated STAT 2 [ Homo sapiens (human) ]

Gene ID: 9063, updated on 4-Nov-2018

Summary

Official Symbol
PIAS2provided by HGNC
Official Full Name
protein inhibitor of activated STAT 2provided by HGNC
Primary source
HGNC:HGNC:17311
See related
Ensembl:ENSG00000078043 MIM:603567; Vega:OTTHUMG00000179301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIP; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4
Summary
This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
Expression
Broad expression in testis (RPKM 8.9), thyroid (RPKM 2.1) and 23 other tissues See more
Orthologs

Genomic context

See PIAS2 in Genome Data Viewer
Location:
18q21.1
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (46803224..46920167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44388900..44500130, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene ribosomal protein S21 pseudogene 6 Neighboring gene uncharacterized LOC105372097 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene elongin A3 family member D Neighboring gene elongin A3 family member C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Activation of HOX genes during differentiation, organism-specific biosystem (from REACTOME)
    Activation of HOX genes during differentiation, organism-specific biosystemHox genes encode proteins that contain the DNA-binding homeobox motif and control early patterning of segments in the embryo as well as later events in development (reviewed in Rezsohazy et al. 2015)...
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystem (from REACTOME)
    Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystemIn mammals, anterior Hox genes may be defined as paralog groups 1 to 4 (Natale et al. 2011), which are involved in development of the hindbrain through sequential expression in the rhombomeres, trans...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
    IL12 signaling mediated by STAT4, organism-specific biosystem
    IL12 signaling mediated by STAT4
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
    SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
    Sumoylation by RanBP2 regulates transcriptional repression
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
PubMed 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase PIAS2
Names
DAB2-interacting protein
E3 SUMO-protein transferase PIAS2
androgen receptor-interacting protein 3
msx-interacting zinc finger protein
protein inhibitor of activated STAT X
zinc finger, MIZ-type containing 4
NP_001310975.1
NP_001310976.1
NP_001310977.1
NP_001310978.1
NP_001310980.1
NP_001310981.1
NP_001310982.1
NP_001310983.1
NP_001310984.1
NP_001310986.1
NP_001310987.1
NP_001310988.1
NP_001310989.1
NP_001340962.1
NP_001340963.1
NP_001340964.1
NP_001340965.1
NP_001340966.1
NP_001340967.1
NP_001340968.1
NP_004662.2
NP_775298.1
XP_005258434.1
XP_006722634.1
XP_006722635.1
XP_006722636.1
XP_011524560.1
XP_016881561.1
XP_024307050.1
XP_024307051.1
XP_024307052.1
XP_024307053.1
XP_024307054.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029865.2 RefSeqGene

    Range
    5001..119309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324046.1NP_001310975.1  E3 SUMO-protein ligase PIAS2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  2. NM_001324047.1NP_001310976.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  3. NM_001324048.1NP_001310977.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A024RC49
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  4. NM_001324049.1NP_001310978.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    UniProtKB/TrEMBL
    A0A024RC49
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  5. NM_001324051.1NP_001310980.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  6. NM_001324052.1NP_001310981.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  7. NM_001324053.1NP_001310982.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  8. NM_001324054.1NP_001310983.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  9. NM_001324055.1NP_001310984.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  10. NM_001324057.1NP_001310986.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  11. NM_001324058.1NP_001310987.1  E3 SUMO-protein ligase PIAS2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, BC111060
    UniProtKB/TrEMBL
    Q2TA77
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:342390
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:145282
    PINIT; PINIT domain
  12. NM_001324059.1NP_001310988.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Related
    ENSP00000479025.1, OTTHUMP00000274528, ENST00000592212.5, OTTHUMT00000445659
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  13. NM_001324060.1NP_001310989.1  E3 SUMO-protein ligase PIAS2 isoform NY

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform NY from PMID: 15301740.
    Source sequence(s)
    AC090241, AF361054, DB024780
    UniProtKB/Swiss-Prot
    O75928
  14. NM_001354033.1NP_001340962.1  E3 SUMO-protein ligase PIAS2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  15. NM_001354034.1NP_001340963.1  E3 SUMO-protein ligase PIAS2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  16. NM_001354035.1NP_001340964.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  17. NM_001354036.1NP_001340965.1  E3 SUMO-protein ligase PIAS2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  18. NM_001354037.1NP_001340966.1  E3 SUMO-protein ligase PIAS2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  19. NM_001354038.1NP_001340967.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  20. NM_001354039.1NP_001340968.1  E3 SUMO-protein ligase PIAS2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  21. NM_004671.4NP_004662.2  E3 SUMO-protein ligase PIAS2 isoform beta

    See identical proteins and their annotated locations for NP_004662.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) encodes isoform (beta).
    Source sequence(s)
    AC090241, AF077954, AF086240, BG718291
    Consensus CDS
    CCDS32824.1
    UniProtKB/Swiss-Prot
    O75928
    Related
    ENSP00000465676.1, OTTHUMP00000261097, ENST00000585916.5, OTTHUMT00000445656
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  22. NM_173206.3NP_775298.1  E3 SUMO-protein ligase PIAS2 isoform alpha

    See identical proteins and their annotated locations for NP_775298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) utilizes an alternate 3' coding exon, compared to variant beta, resulting in a shorter isoform (alpha) that has a unique C-terminus compared to isoform beta.
    Source sequence(s)
    AC090241, BC015190, BG718291
    Consensus CDS
    CCDS32825.1
    UniProtKB/Swiss-Prot
    O75928
    Related
    ENSP00000317163.6, OTTHUMP00000261099, ENST00000324794.11, OTTHUMT00000445658
    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

RNA

  1. NR_136684.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, AF086240, AK308143
  2. NR_136685.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373, AK294801
  3. NR_148699.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  4. NR_148700.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  5. NR_148701.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  6. NR_148702.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373
  7. NR_148703.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090241, AC090373

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    46803224..46920167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451283.1XP_024307051.1  E3 SUMO-protein ligase PIAS2 isoform X8

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:186330
    PINIT; PINIT domain
    cd16790
    Location:382429
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  2. XM_024451284.1XP_024307052.1  E3 SUMO-protein ligase PIAS2 isoform X8

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:186330
    PINIT; PINIT domain
    cd16790
    Location:382429
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  3. XM_006722571.3XP_006722634.1  E3 SUMO-protein ligase PIAS2 isoform X1

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:381429
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:184321
    PINIT; PINIT domain
  4. XM_024451285.1XP_024307053.1  E3 SUMO-protein ligase PIAS2 isoform X9

    Conserved Domains (3) summary
    smart00513
    Location:1145
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:147291
    PINIT; PINIT domain
    cd16790
    Location:343390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  5. XM_024451286.1XP_024307054.1  E3 SUMO-protein ligase PIAS2 isoform X10

    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  6. XM_005258377.3XP_005258434.1  E3 SUMO-protein ligase PIAS2 isoform X3

    See identical proteins and their annotated locations for XP_005258434.1

    Conserved Domains (3) summary
    smart00513
    Location:1549
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:346394
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:149286
    PINIT; PINIT domain
  7. XM_006722572.3XP_006722635.1  E3 SUMO-protein ligase PIAS2 isoform X2

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:381429
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:184321
    PINIT; PINIT domain
  8. XM_024451282.1XP_024307050.1  E3 SUMO-protein ligase PIAS2 isoform X5

    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  9. XM_011526258.2XP_011524560.1  E3 SUMO-protein ligase PIAS2 isoform X4

    Conserved Domains (3) summary
    smart00513
    Location:943
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:145289
    PINIT; PINIT domain
    cd16790
    Location:341388
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
  10. XM_006722573.2XP_006722636.1  E3 SUMO-protein ligase PIAS2 isoform X6

    Conserved Domains (3) summary
    smart00513
    Location:5084
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:381429
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:184321
    PINIT; PINIT domain
  11. XM_017026072.1XP_016881561.1  E3 SUMO-protein ligase PIAS2 isoform X7

    Conserved Domains (3) summary
    smart00513
    Location:236
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam14324
    Location:138282
    PINIT; PINIT domain
    cd16790
    Location:334381
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins

RNA

  1. XR_001753298.1 RNA Sequence

  2. XR_001753300.1 RNA Sequence

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