U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    STX3 syntaxin 3 [ Homo sapiens (human) ]

    Gene ID: 6809, updated on 6-Jun-2024

    Summary

    Official Symbol
    STX3provided by HGNC
    Official Full Name
    syntaxin 3provided by HGNC
    Primary source
    HGNC:HGNC:11438
    See related
    Ensembl:ENSG00000166900 MIM:600876; AllianceGenome:HGNC:11438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MVID2; STX3A; DIAR12; RDMVID
    Summary
    The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in colon (RPKM 9.8), duodenum (RPKM 8.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STX3 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59754188..59805878)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59706662..59757169)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59522849..59573351)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily V member 3 pseudogene Neighboring gene Sharpr-MPRA regulatory regions 192 and 10030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3369 Neighboring gene olfactory receptor family 10 subfamily V member 2 pseudogene Neighboring gene fatty acid binding protein 5 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4762 Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene cobalamin binding intrinsic factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30906

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arachidonic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in azurophil granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor inner segment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in photoreceptor outer segment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in specific granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vacuole TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    syntaxin-3
    Names
    syntaxin 3A
    syntaxin 3B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047082.1 RefSeqGene

      Range
      5318..55820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178040.2NP_001171511.1  syntaxin-3 isoform 2

      See identical proteins and their annotated locations for NP_001171511.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA858058, AK125660, AK297419, AP000640
      Consensus CDS
      CCDS53637.1
      UniProtKB/TrEMBL
      A0A0J9YW33
      Related
      ENSP00000433248.1, ENST00000529177.5
      Conserved Domains (3) summary
      cd00179
      Location:32181
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15881
      Location:190258
      SNARE_syntaxin3; SNARE motif of syntaxin 3
      pfam00804
      Location:32226
      Syntaxin; Syntaxin
    2. NM_004177.5NP_004168.1  syntaxin-3 isoform 1

      See identical proteins and their annotated locations for NP_004168.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA858058, AK125660, AP000640, BC007405
      Consensus CDS
      CCDS7975.1
      UniProtKB/Swiss-Prot
      B4DME0, O43750, O43751, Q13277, Q15360
      UniProtKB/TrEMBL
      Q53YE2, Q7Z338
      Related
      ENSP00000338562.4, ENST00000337979.9
      Conserved Domains (2) summary
      pfam00804
      Location:32226
      Syntaxin; Syntaxin
      cl22856
      Location:194260
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      59754188..59805878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427501.1XP_047283457.1  syntaxin-3 isoform X5

      UniProtKB/TrEMBL
      A0A286YF28, Q7Z338
      Related
      ENSP00000493027.1, ENST00000641815.1
    2. XM_005274198.4XP_005274255.1  syntaxin-3 isoform X4

      See identical proteins and their annotated locations for XP_005274255.1

      UniProtKB/TrEMBL
      A0A0J9YW33
      Conserved Domains (3) summary
      cd00179
      Location:32181
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15881
      Location:190258
      SNARE_syntaxin3; SNARE motif of syntaxin 3
      pfam00804
      Location:32226
      Syntaxin; Syntaxin
    3. XM_047427500.1XP_047283456.1  syntaxin-3 isoform X3

      UniProtKB/Swiss-Prot
      B4DME0, O43750, O43751, Q13277, Q15360
      UniProtKB/TrEMBL
      Q53YE2, Q7Z338
    4. XM_005274195.5XP_005274252.1  syntaxin-3 isoform X3

      See identical proteins and their annotated locations for XP_005274252.1

      UniProtKB/Swiss-Prot
      B4DME0, O43750, O43751, Q13277, Q15360
      UniProtKB/TrEMBL
      Q53YE2, Q7Z338
      Conserved Domains (2) summary
      pfam00804
      Location:32226
      Syntaxin; Syntaxin
      cl22856
      Location:194260
      SNARE; SNARE motif
    5. XM_047427502.1XP_047283458.1  syntaxin-3 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DGE4
    6. XM_047427503.1XP_047283459.1  syntaxin-3 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DGE4
      Related
      ENSP00000431386.1, ENST00000528805.1
    7. XM_017018192.2XP_016873681.2  syntaxin-3 isoform X2

      UniProtKB/TrEMBL
      A0A0J9YW33
    8. XM_017018193.2XP_016873682.2  syntaxin-3 isoform X2

      UniProtKB/TrEMBL
      A0A0J9YW33
    9. XM_017018191.2XP_016873680.2  syntaxin-3 isoform X1

      UniProtKB/TrEMBL
      Q7Z338

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      59706662..59757169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369762.1XP_054225737.1  syntaxin-3 isoform X3

      UniProtKB/Swiss-Prot
      B4DME0, O43750, O43751, Q13277, Q15360
      UniProtKB/TrEMBL
      Q53YE2, Q7Z338
    2. XM_054369764.1XP_054225739.1  syntaxin-3 isoform X4

      UniProtKB/TrEMBL
      A0A0J9YW33
    3. XM_054369763.1XP_054225738.1  syntaxin-3 isoform X3

      UniProtKB/Swiss-Prot
      B4DME0, O43750, O43751, Q13277, Q15360
      UniProtKB/TrEMBL
      Q53YE2, Q7Z338
    4. XM_054369765.1XP_054225740.1  syntaxin-3 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DGE4
    5. XM_054369766.1XP_054225741.1  syntaxin-3 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DGE4
    6. XM_054369760.1XP_054225735.1  syntaxin-3 isoform X8

      UniProtKB/TrEMBL
      A0A0J9YW33
    7. XM_054369761.1XP_054225736.1  syntaxin-3 isoform X8

      UniProtKB/TrEMBL
      A0A0J9YW33
    8. XM_054369759.1XP_054225734.1  syntaxin-3 isoform X7

      UniProtKB/TrEMBL
      Q7Z338
    9. XM_054369767.1XP_054225742.1  syntaxin-3 isoform X9