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Stx3 syntaxin 3 [ Mus musculus (house mouse) ]

Gene ID: 20908, updated on 8-Dec-2022

Summary

Official Symbol
Stx3provided by MGI
Official Full Name
syntaxin 3provided by MGI
Primary source
MGI:MGI:103077
See related
Ensembl:ENSMUSG00000041488 AllianceGenome:MGI:103077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Syn-3
Summary
Predicted to enable SNAP receptor activity; SNARE binding activity; and arachidonic acid binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane and vesicle-mediated transport in synapse. Acts upstream of or within exocytosis; long-term synaptic potentiation; and vesicle fusion. Located in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and photoreceptor cell terminal bouton. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 14.0), cerebellum adult (RPKM 6.3) and 21 other tissues See more
Orthologs
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Genomic context

See Stx3 in Genome Data Viewer
Location:
19; 19 A
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11752482..11798933, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11775118..11821569, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cobalamin binding intrinsic factor Neighboring gene predicted gene, 46655 Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene predicted gene, 41810 Neighboring gene olfactory receptor family 10 subfamily V member 5 Neighboring gene olfactory receptor family 10 subfamily V member 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arachidonic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane EXP
Inferred from Experiment
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organelle membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport in synapse EXP
Inferred from Experiment
more info
PubMed 
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport in synapse IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport in synapse IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in photoreceptor outer segment IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in zymogen granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in zymogen granule membrane IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025307.2NP_001020478.1  syntaxin-3 isoform B

    See identical proteins and their annotated locations for NP_001020478.1

    Status: VALIDATED

    Source sequence(s)
    BC024844, BC056949, BM936677
    Consensus CDS
    CCDS29611.1
    UniProtKB/Swiss-Prot
    Q64704
    UniProtKB/TrEMBL
    A0A6P5P0F3, A0A8C6N5F7
    Related
    ENSMUSP00000074776.8, ENSMUST00000075304.14
    Conserved Domains (2) summary
    pfam00804
    Location:32226
    Syntaxin
    cl22856
    Location:194260
    SNARE; SNARE motif
  2. NM_001286543.2NP_001273472.1  syntaxin-3 isoform D

    See identical proteins and their annotated locations for NP_001273472.1

    Status: VALIDATED

    Source sequence(s)
    AC126266, BC024844, BC056949
    UniProtKB/Swiss-Prot
    Q64704
    UniProtKB/TrEMBL
    A0A6P5P0R7
    Conserved Domains (2) summary
    pfam00804
    Location:1129
    Syntaxin
    cl22856
    Location:97163
    SNARE; SNARE motif
  3. NM_001360386.1NP_001347315.1  syntaxin-3 isoform D

    Status: VALIDATED

    Source sequence(s)
    AC126036, AC126266
    UniProtKB/TrEMBL
    A0A6P5P0R7
    Conserved Domains (2) summary
    pfam00804
    Location:1129
    Syntaxin
    cl22856
    Location:97163
    SNARE; SNARE motif
  4. NM_011502.4NP_035632.1  syntaxin-3 isoform C

    See identical proteins and their annotated locations for NP_035632.1

    Status: VALIDATED

    Source sequence(s)
    AC126266, BC024844, BC056949
    Consensus CDS
    CCDS29612.1
    UniProtKB/Swiss-Prot
    Q64704
    Related
    ENSMUSP00000147398.2, ENSMUST00000211641.2
    Conserved Domains (2) summary
    pfam00804
    Location:49208
    Syntaxin; Syntaxin
    cl22856
    Location:176242
    SNARE; SNARE motif
  5. NM_152220.2NP_689344.1  syntaxin-3 isoform A

    See identical proteins and their annotated locations for NP_689344.1

    Status: VALIDATED

    Source sequence(s)
    AC126266, AK133830, BC056949, BF318335, BG064925, BG079344, BX634318, CJ058200
    Consensus CDS
    CCDS29613.1
    UniProtKB/Swiss-Prot
    Q64704, Q8R1B7
    UniProtKB/TrEMBL
    A0A6P7QUQ9, A0A8C6IIF2, Q3UZI9
    Related
    ENSMUSP00000069529.5, ENSMUST00000069285.6
    Conserved Domains (2) summary
    pfam00804
    Location:32226
    Syntaxin
    cl22856
    Location:194260
    SNARE; SNARE motif

RNA

  1. NR_153433.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126036, AC126266
  2. NR_153434.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126036, AC126266
    Related
    ENSMUST00000047698.14

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    11752482..11798933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161504.1XP_036017397.1  syntaxin-3 isoform X2

    Conserved Domains (2) summary
    pfam00804
    Location:1129
    Syntaxin
    cl22856
    Location:97163
    SNARE; SNARE motif
  2. XM_036161503.1XP_036017396.1  syntaxin-3 isoform X2

    Conserved Domains (2) summary
    pfam00804
    Location:1129
    Syntaxin
    cl22856
    Location:97163
    SNARE; SNARE motif
  3. XM_006526844.4XP_006526907.1  syntaxin-3 isoform X1

    Conserved Domains (2) summary
    pfam00804
    Location:32226
    Syntaxin
    cl22856
    Location:194260
    SNARE; SNARE motif

RNA

  1. XR_001782567.2 RNA Sequence

  2. XR_001782569.2 RNA Sequence

  3. XR_001782568.2 RNA Sequence

  4. XR_004940132.1 RNA Sequence

  5. XR_003952772.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025308.1: Suppressed sequence

    Description
    NM_001025308.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.