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    SRPK1 SRSF protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 6732, updated on 4-Feb-2024

    Summary

    Official Symbol
    SRPK1provided by HGNC
    Official Full Name
    SRSF protein kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:11305
    See related
    Ensembl:ENSG00000096063 MIM:601939; AllianceGenome:HGNC:11305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFRSK1
    Summary
    This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
    Expression
    Broad expression in testis (RPKM 31.4), bone marrow (RPKM 17.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SRPK1 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35832966..35921098, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35653298..35741415, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35800743..35888875, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17101 Neighboring gene colipase Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:35810876-35811031 Neighboring gene uncharacterized LOC124901311 Neighboring gene MPRA-validated peak5780 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17103 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35899139-35899789 Neighboring gene solute carrier family 26 member 8 Neighboring gene uncharacterized LOC105375035 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:35960877-35961390 Neighboring gene uncharacterized LOC105375034 Neighboring gene divergent-paired related homeobox pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    SRSF protein kinase 1
    Names
    SFRS protein kinase 1
    SR-protein-specific kinase 1
    serine/arginine-rich splicing factor kinase 1
    serine/threonine-protein kinase SRPK1
    NP_003128.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029520.1 RefSeqGene

      Range
      5083..93215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003137.5NP_003128.3  SRSF protein kinase 1

      See identical proteins and their annotated locations for NP_003128.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript.
      Source sequence(s)
      AK299591, BC038292, BX648697, Z99128
      Consensus CDS
      CCDS47415.1
      UniProtKB/Swiss-Prot
      B4DS61, Q12890, Q5R364, Q5R365, Q8IY12, Q96SB4
      UniProtKB/TrEMBL
      A8K8B2
      Related
      ENSP00000362931.2, ENST00000373825.7
      Conserved Domains (2) summary
      cd14216
      Location:477653
      STKc_SRPK1; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 1
      cl21453
      Location:69282
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_034069.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' end, compared to variant 1, which results in a novel exon segment that contains an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the protein is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK299591, BX648663, Z99128
      Related
      ENST00000423325.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      35832966..35921098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      35653298..35741415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)