U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Srpk1 serine/arginine-rich protein specific kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 20815, updated on 27-Feb-2024

Summary

Official Symbol
Srpk1provided by MGI
Official Full Name
serine/arginine-rich protein specific kinase 1provided by MGI
Primary source
MGI:MGI:106908
See related
Ensembl:ENSMUSG00000004865 AllianceGenome:MGI:106908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction; protein phosphorylation; and regulation of mRNA processing. Predicted to be located in several cellular components, including chromatin; cytosol; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SRPK1 (SRSF protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 40.4), CNS E11.5 (RPKM 17.6) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Srpk1 in Genome Data Viewer
Location:
17 A3.3; 17 14.78 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28806622..28841795, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28587648..28622528, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42221 Neighboring gene microRNA 6969 Neighboring gene colipase, pancreatic Neighboring gene lipoma HMGIC fusion partner-like 5 Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene STARR-seq mESC enhancer starr_42228 Neighboring gene solute carrier family 26, member 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28828272-28828381 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene G protein subunit gamma 5C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SRSF protein kinase 1
Names
SFRS protein kinase 1
SR-protein-specific kinase 1
serine/threonine-protein kinase SRPK1
NP_058075.2
XP_011244639.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016795.4NP_058075.2  SRSF protein kinase 1

    See identical proteins and their annotated locations for NP_058075.2

    Status: VALIDATED

    Source sequence(s)
    AK141271, AK151152, BE848006
    Consensus CDS
    CCDS37531.1
    UniProtKB/Swiss-Prot
    O70193, O70551, Q99JT3
    UniProtKB/TrEMBL
    Q3UB06
    Related
    ENSMUSP00000116259.2, ENSMUST00000130643.9
    Conserved Domains (2) summary
    smart00220
    Location:80224
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70646
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28806622..28841795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246337.4XP_011244639.1  SRSF protein kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011244639.1

    Conserved Domains (1) summary
    cl21453
    Location:69241
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_385308.5 RNA Sequence

    Related
    ENSMUST00000233440.2
  2. XR_004939484.1 RNA Sequence

  3. XR_004939483.1 RNA Sequence