U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TRIM54 tripartite motif containing 54 [ Homo sapiens (human) ]

    Gene ID: 57159, updated on 5-Aug-2022

    Summary

    Official Symbol
    TRIM54provided by HGNC
    Official Full Name
    tripartite motif containing 54provided by HGNC
    Primary source
    HGNC:HGNC:16008
    See related
    Ensembl:ENSG00000138100 MIM:606474; AllianceGenome:HGNC:16008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MURF; RNF30; muRF3; MURF-3
    Summary
    The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in heart (RPKM 35.4), testis (RPKM 5.2) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM54 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27282429..27307435)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27324049..27349850)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27505297..27530303)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene solute carrier family 30 member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene GTF3C2 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule-based process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of microtubule associated complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tripartite motif-containing protein 54
    Names
    muscle-specific RING finger protein 3
    ring finger protein 30

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032546.4NP_115935.3  tripartite motif-containing protein 54 isoform 1

      See identical proteins and their annotated locations for NP_115935.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AJ291714, BC141807, DA897004
      Consensus CDS
      CCDS1745.2
      UniProtKB/Swiss-Prot
      Q9BYV2
      Related
      ENSP00000296098.4, ENST00000296098.4
      Conserved Domains (2) summary
      cd16761
      Location:2482
      RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
      cd19833
      Location:124166
      Bbox2_MuRF3_C-II; B-box-type 2 zinc finger found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
    2. NM_187841.3NP_912730.2  tripartite motif-containing protein 54 isoform 2

      See identical proteins and their annotated locations for NP_912730.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment within the coding region. The resulting shorter isoform (2) lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      BC141807, DA897004
      Consensus CDS
      CCDS1746.2
      UniProtKB/Swiss-Prot
      Q9BYV2, Q9BYV3
      Related
      ENSP00000369415.3, ENST00000380075.7
      Conserved Domains (2) summary
      pfam00643
      Location:122163
      zf-B_box; B-box zinc finger
      cd16761
      Location:2482
      RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27282429..27307435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453010.1XP_024308778.1  tripartite motif-containing protein 54 isoform X1

      UniProtKB/Swiss-Prot
      Q9BYV3
      Conserved Domains (2) summary
      pfam00643
      Location:122163
      zf-B_box; B-box zinc finger
      cd16761
      Location:2482
      RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
    2. XM_024453011.2XP_024308779.1  tripartite motif-containing protein 54 isoform X2

      Conserved Domains (2) summary
      pfam00643
      Location:122163
      zf-B_box; B-box zinc finger
      cd16761
      Location:2482
      RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
    3. XM_024453012.2XP_024308780.1  tripartite motif-containing protein 54 isoform X3

      Conserved Domains (2) summary
      pfam00643
      Location:122163
      zf-B_box; B-box zinc finger
      cd16761
      Location:2482
      RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27324049..27349850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)