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Trim54 tripartite motif-containing 54 [ Mus musculus (house mouse) ]

Gene ID: 58522, updated on 26-Sep-2022

Summary

Official Symbol
Trim54provided by MGI
Official Full Name
tripartite motif-containing 54provided by MGI
Primary source
MGI:MGI:1889623
See related
Ensembl:ENSMUSG00000062077 AllianceGenome:MGI:1889623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MURF; MuRF3; Rnf30; MURF-3; 4930486E09Rik; 4930566I02Rik
Summary
Enables microtubule binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Part of microtubule associated complex. Is expressed in several structures, including diaphragm; heart; lung; skeletal musculature; and trunk dermomyotome. Orthologous to human TRIM54 (tripartite motif containing 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 63.3), mammary gland adult (RPKM 10.6) and 2 other tissues See more
Orthologs
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Genomic context

See Trim54 in Genome Data Viewer
Location:
5; 5 B1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31273956..31294970)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31116612..31137626)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 (zinc transporter), member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene predicted gene 15469 Neighboring gene urocortin Neighboring gene MpV17 mitochondrial inner membrane protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130201, MGC130202

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
part_of microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 54
Names
muscle-specific RING finger protein 3
muscle-specific RING-finger protein
ring finger protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021447.2NP_067422.1  tripartite motif-containing protein 54

    See identical proteins and their annotated locations for NP_067422.1

    Status: VALIDATED

    Source sequence(s)
    AF294790, BY346743
    Consensus CDS
    CCDS19173.1
    UniProtKB/Swiss-Prot
    Q9ERP3
    Related
    ENSMUSP00000013771.9, ENSMUST00000013771.15
    Conserved Domains (3) summary
    cd00162
    Location:2685
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:125163
    zf-B_box; B-box zinc finger
    cl23765
    Location:170273
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31273956..31294970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)