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    ZCCHC10 zinc finger CCHC-type containing 10 [ Homo sapiens (human) ]

    Gene ID: 54819, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZCCHC10provided by HGNC
    Official Full Name
    zinc finger CCHC-type containing 10provided by HGNC
    Primary source
    HGNC:HGNC:25954
    See related
    Ensembl:ENSG00000155329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in lymph node (RPKM 8.3), testis (RPKM 8.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZCCHC10 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132996985..133026621, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132332677..132362275, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family member 4 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 1 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27 pseudogene Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene heat shock protein family A (Hsp70) member 4 Neighboring gene uncharacterized LOC105379178

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20094

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger CCHC domain-containing protein 10
    Names
    zinc finger, CCHC domain containing 10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300816.3NP_001287745.1  zinc finger CCHC domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_001287745.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443
      Consensus CDS
      CCDS75301.1
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
      Related
      ENSP00000423276.1, ENST00000509437.6
      Conserved Domains (1) summary
      pfam13917
      Location:3976
      zf-CCHC_3; Zinc knuckle
    2. NM_001300817.3NP_001287746.1  zinc finger CCHC domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001287746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK122970, AK300543, BC022443
      Consensus CDS
      CCDS78060.1
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B3KVL5, B4DU89
      Related
      ENSP00000347533.2, ENST00000355372.6
      Conserved Domains (1) summary
      pfam13917
      Location:3976
      zf-CCHC_3; Zinc knuckle
    3. NM_001300818.3NP_001287747.1  zinc finger CCHC domain-containing protein 10 isoform 3

      See identical proteins and their annotated locations for NP_001287747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443, BU165290
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
      Conserved Domains (1) summary
      pfam13917
      Location:3976
      zf-CCHC_3; Zinc knuckle
    4. NM_001300819.3NP_001287748.1  zinc finger CCHC domain-containing protein 10 isoform 5

      See identical proteins and their annotated locations for NP_001287748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in both the 5' and 3' coding regions, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443
      Consensus CDS
      CCDS75300.1
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89, G3XAM1
      Related
      ENSP00000427430.1, ENST00000513848.5
      Conserved Domains (1) summary
      pfam13917
      Location:1754
      zf-CCHC_3; Zinc knuckle
    5. NM_001300822.3NP_001287751.1  zinc finger CCHC domain-containing protein 10 isoform 6

      See identical proteins and their annotated locations for NP_001287751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1, resulting in an isoform (6) that has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BC022443, CB112418
      Consensus CDS
      CCDS75302.1
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89, D6R9G7
      Related
      ENSP00000422111.1, ENST00000513541.5
      Conserved Domains (1) summary
      pfam13917
      Location:3976
      zf-CCHC_3; Zinc knuckle
    6. NM_001308127.2NP_001295056.1  zinc finger CCHC domain-containing protein 10 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (9) that is longer than isoform 1.
      Source sequence(s)
      AK000101, DA905071
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
      Conserved Domains (1) summary
      pfam13917
      Location:4988
      zf-CCHC_3; Zinc knuckle
    7. NM_001308128.2NP_001295057.1  zinc finger CCHC domain-containing protein 10 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (10) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, DA345717
      UniProtKB/Swiss-Prot
      Q8TBK6
    8. NM_001308129.2NP_001295058.1  zinc finger CCHC domain-containing protein 10 isoform 11

      See identical proteins and their annotated locations for NP_001295058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) lacks three alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (11) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, BI766652
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
    9. NM_001308130.2NP_001295059.1  zinc finger CCHC domain-containing protein 10 isoform 12

      See identical proteins and their annotated locations for NP_001295059.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (12) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543, DA528172
      Consensus CDS
      CCDS78059.1
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89, D6RHC2
      Related
      ENSP00000421071.1, ENST00000509008.1
      Conserved Domains (1) summary
      pfam13917
      Location:1754
      zf-CCHC_3; Zinc knuckle
    10. NM_017665.4NP_060135.1  zinc finger CCHC domain-containing protein 10 isoform 4

      See identical proteins and their annotated locations for NP_060135.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
      Source sequence(s)
      AK000101, AK300543
      Consensus CDS
      CCDS4165.1
      UniProtKB/Swiss-Prot
      Q8TBK6
      UniProtKB/TrEMBL
      B4DU89
      Related
      ENSP00000324274.3, ENST00000324170.7
      Conserved Domains (1) summary
      pfam13917
      Location:1754
      zf-CCHC_3; Zinc knuckle

    RNA

    1. NR_125337.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK000101, AK300543, BG699335, BI826979, BM470321
    2. NR_131766.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in the 5' terminal exon, lacks an internal exon but contains a different internal exon, and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK000101, AK300543, BG699335, BI826979, DA466245
    3. NR_131767.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK000101, AK300543, BF983215, BI826979

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      132996985..133026621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543503.2XP_011541805.1  zinc finger CCHC domain-containing protein 10 isoform X2

      Conserved Domains (1) summary
      pfam13917
      Location:4988
      zf-CCHC_3; Zinc knuckle
    2. XM_011543502.1XP_011541804.1  zinc finger CCHC domain-containing protein 10 isoform X1

      Conserved Domains (1) summary
      pfam13917
      Location:4988
      zf-CCHC_3; Zinc knuckle
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