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    ANAPC11 anaphase promoting complex subunit 11 [ Homo sapiens (human) ]

    Gene ID: 51529, updated on 17-Jun-2024

    Summary

    Official Symbol
    ANAPC11provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 11provided by HGNC
    Primary source
    HGNC:HGNC:14452
    See related
    Ensembl:ENSG00000141552 MIM:614534; AllianceGenome:HGNC:14452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC11; Apc11p; HSPC214
    Summary
    Enables cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in protein K11-linked ubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 15.1), heart (RPKM 13.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ANAPC11 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81890790..81900533)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82757952..82767693)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79848666..79858409)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79813353-79813852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9154 Neighboring gene uncharacterized LOC124904086 Neighboring gene Sharpr-MPRA regulatory region 9355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79823980-79824608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79825239-79825867 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79825868-79826497 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79826498-79827126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12983 Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:79846281-79847480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9161 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79850899-79851114 Neighboring gene Aly/REF export factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9164 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9166 Neighboring gene neuropeptide B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79875237-79876133 Neighboring gene sirtuin 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: NPB

    Clone Names

    • MGC882

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cullin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 11
    Names
    APC11 anaphase promoting complex subunit 11 homolog
    anaphase promoting complex subunit 11 (yeast APC11 homolog)
    cyclosome subunit 11
    hepatocellular carcinoma-associated RING finger protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002244.2NP_001002244.1  anaphase-promoting complex subunit 11 isoform 1

      See identical proteins and their annotated locations for NP_001002244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK308091, BC000607, HY067392
      Consensus CDS
      CCDS32769.1
      Related
      ENSP00000349957.3, ENST00000357385.7
      Conserved Domains (1) summary
      cl17238
      Location:151
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. NM_001002245.2NP_001002245.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000461648.2, ENST00000571024.6
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. NM_001002246.2NP_001002246.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AF151048, AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000460064.2, ENST00000574924.6
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    4. NM_001002247.2NP_001002247.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000463640.1, ENST00000579978.5
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    5. NM_001002248.3NP_001002248.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AF151048, AK308091, BC000607, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000339695.5, ENST00000344877.10
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    6. NM_001002249.2NP_001002249.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001002249.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC066308, BM845909
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000376181.3, ENST00000392376.7
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    7. NM_001289414.1NP_001276343.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an exon and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AA356010, AK308091, AW965775
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000458143.1, ENST00000571570.5
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    8. NM_001289415.1NP_001276344.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC171898, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000458265.2, ENST00000572851.6
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    9. NM_001289416.1NP_001276345.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) lacks an exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AK308091, BC066308, BM845909, BY796995
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000463598.1, ENST00000583839.1
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    10. NM_001289417.1NP_001276346.1  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_001276346.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) uses an alternate splice site and contains two alternate exons in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AC145207, AK308091, CA335305, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000464615.1, ENST00000578550.5
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    11. NM_001289420.1NP_001276349.1  anaphase-promoting complex subunit 11 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) lacks an exon and contains two alternate exons in the 5' UTR, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC145207, AK308091, BC066308, BM762129, BM845909
      UniProtKB/Swiss-Prot
      Q9NYG5
      Conserved Domains (2) summary
      pfam12678
      Location:237
      zf-rbx1; RING-H2 zinc finger
      cl17238
      Location:151
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    12. NM_016476.11NP_057560.8  anaphase-promoting complex subunit 11 isoform 2

      See identical proteins and their annotated locations for NP_057560.8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 encode the isoform 2.
      Source sequence(s)
      AF151048, AK308091, BC000607, BF512771, HY067392
      Consensus CDS
      CCDS11789.1
      UniProtKB/Swiss-Prot
      A8MTT2, B7ZW64, Q502X9, Q9BW64, Q9NYG5, Q9P0R2
      Related
      ENSP00000459200.2, ENST00000571874.6
      Conserved Domains (1) summary
      cl17238
      Location:184
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81890790..81900533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82757952..82767693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001289418.1: Suppressed sequence

      Description
      NM_001289418.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    2. NM_001289419.1: Suppressed sequence

      Description
      NM_001289419.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.