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NPB neuropeptide B [ Homo sapiens (human) ]

Gene ID: 256933, updated on 18-Aug-2020

Summary

Official Symbol
NPBprovided by HGNC
Official Full Name
neuropeptide Bprovided by HGNC
Primary source
HGNC:HGNC:30099
See related
Ensembl:ENSG00000183979 MIM:607996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L7; PPL7; PPNPB
Summary
This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
Expression
Biased expression in kidney (RPKM 3.4), fat (RPKM 2.9) and 12 other tissues See more
Orthologs

Genomic context

See NPB in Genome Data Viewer
Location:
17q25.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81902238..81902905)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79860072..79860781)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene sirtuin 7 Neighboring gene MAF bZIP transcription factor G

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide B
Names
prepro-NPB
preproneuropeptide B
preproprotein L7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148896.5NP_683694.1  neuropeptide B preproprotein

    See identical proteins and their annotated locations for NP_683694.1

    Status: REVIEWED

    Source sequence(s)
    BC126128, BM978256
    Consensus CDS
    CCDS11790.1
    UniProtKB/Swiss-Prot
    Q8NG41
    Related
    ENSP00000332766.7, ENST00000333383.8
    Conserved Domains (1) summary
    pfam15180
    Location:20124
    NPBW; Neuropeptides B and W

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81902238..81902905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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