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    ATP2B2 ATPase plasma membrane Ca2+ transporting 2 [ Homo sapiens (human) ]

    Gene ID: 491, updated on 17-Jun-2019

    Summary

    Official Symbol
    ATP2B2provided by HGNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 2provided by HGNC
    Primary source
    HGNC:HGNC:815
    See related
    Ensembl:ENSG00000157087 MIM:108733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PMCA2; PMCA2a; PMCA2i
    Summary
    The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 26.8), salivary gland (RPKM 5.2) and 1 other tissue See more
    Orthologs

    Genomic context

    See ATP2B2 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (10324023..10707962, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10365707..10733131, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 852 Neighboring gene ghrelin opposite strand/antisense RNA Neighboring gene ghrelin and obestatin prepropeptide Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene microRNA 378b Neighboring gene microRNA 885 Neighboring gene Sharpr-MPRA regulatory region 15222 Neighboring gene ATP2B2 intronic transcript 2 Neighboring gene Sharpr-MPRA regulatory region 1605 Neighboring gene long intergenic non-protein coding RNA 606

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Deafness, autosomal recessive 12 not available

    NHGRI GWAS Catalog

    Description
    Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
    NHGRI GWA Catalog
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Ion homeostasis, organism-specific biosystem (from REACTOME)
      Ion homeostasis, organism-specific biosystemIon channel homeostasis in relation to cardiac conduction is described in this section (Couette et al. 2006, Bartos et al. 2015).
    • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
      Ion transport by P-type ATPases, organism-specific biosystemThe P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catal...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
      Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
      Reduction of cytosolic Ca++ levels, organism-specific biosystemDuring steady state conditions, cytoplasmic [Ca2+] is reduced by the accumulation of Ca2+ in intracellular stores and Ca2+ extrusion.
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cardiac conduction TAS
    Traceable Author Statement
    more info
     
    regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    plasma membrane calcium-transporting ATPase 2
    Names
    ATPase, Ca++ transporting, plasma membrane 2
    plasma membrane Ca(2+)-ATPase
    plasma membrane Ca2+ pump 2
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    NP_001001331.1
    NP_001317540.1
    NP_001340493.1
    NP_001350791.1
    NP_001674.2
    XP_005265236.1
    XP_006713238.1
    XP_011532054.1
    XP_016861970.1
    XP_016861971.1
    XP_016861972.1
    XP_016861973.1
    XP_016861974.1
    XP_016861975.1
    XP_016861976.1
    XP_016861977.1
    XP_016861978.1
    XP_016861981.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012046.2 RefSeqGene

      Range
      207375..389009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001001331.4NP_001001331.1  plasma membrane calcium-transporting ATPase 2 isoform 1

      See identical proteins and their annotated locations for NP_001001331.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1), also known as WB.
      Source sequence(s)
      AB210008, AC022384, AK308898, S95738, X63575
      Consensus CDS
      CCDS33701.1
      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Related
      ENSP00000353414.2, ENST00000360273.7
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    2. NM_001330611.3NP_001317540.1  plasma membrane calcium-transporting ATPase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three in-frame exons in the 5' coding region, and contains two additional exons in the 3' coding regions, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC018839, AC022384, AC090841
      Consensus CDS
      CCDS82733.1
      UniProtKB/Swiss-Prot
      Q01814
      Related
      ENSP00000424494.1, ENST00000460129.5
    3. NM_001353564.1NP_001340493.1  plasma membrane calcium-transporting ATPase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks three in-frame exons, compared to variant 1. The encoded isoform (2), also known as ZB, is shorter, compared to isoform 1. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC022384, AC090841, BM681464, L20977
      Consensus CDS
      CCDS2601.1
      Conserved Domains (2) summary
      pfam12424
      Location:10811127
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:121042
      E1-E2_ATPase; E1-E2 ATPase
    4. NM_001363862.1NP_001350791.1  plasma membrane calcium-transporting ATPase 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018839, AC022384, AC090841
      Consensus CDS
      CCDS87040.1
      Conserved Domains (2) summary
      pfam12424
      Location:10811121
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:121042
      E1-E2_ATPase; E1-E2 ATPase
    5. NM_001683.5NP_001674.2  plasma membrane calcium-transporting ATPase 2 isoform 2

      See identical proteins and their annotated locations for NP_001674.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three in-frame exons, compared to variant 1. The encoded isoform (2), also known as ZB, is shorter, compared to isoform 1. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AB210008, AC022384, AK308898, X63575
      Consensus CDS
      CCDS2601.1
      UniProtKB/TrEMBL
      A0A024R2E4, Q4LE63
      Related
      ENSP00000373311.4, ENST00000383800.8
      Conserved Domains (2) summary
      pfam12424
      Location:10811127
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:121042
      E1-E2_ATPase; E1-E2 ATPase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      10324023..10707962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006487.1XP_016861976.1  plasma membrane calcium-transporting ATPase 2 isoform X5

      UniProtKB/TrEMBL
      A0A024R2E4, Q4LE63
      Related
      ENSP00000494381.1, ENST00000646379.1
      Conserved Domains (2) summary
      pfam12424
      Location:10811127
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:121042
      E1-E2_ATPase; E1-E2 ATPase
    2. XM_017006488.2XP_016861977.1  plasma membrane calcium-transporting ATPase 2 isoform X6

      Conserved Domains (7) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161457
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8721050
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10951159
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:659798
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:518607
      Cation_ATPase; Cation transport ATPase (P-type)
    3. XM_017006492.2XP_016861981.1  plasma membrane calcium-transporting ATPase 2 isoform X9

    4. XM_017006485.2XP_016861974.1  plasma membrane calcium-transporting ATPase 2 isoform X3

      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261190
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    5. XM_017006486.2XP_016861975.1  plasma membrane calcium-transporting ATPase 2 isoform X4

      UniProtKB/Swiss-Prot
      Q01814
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261190
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    6. XM_017006489.2XP_016861978.1  plasma membrane calcium-transporting ATPase 2 isoform X7

      UniProtKB/Swiss-Prot
      Q01814
      Related
      ENSP00000495924.1, ENST00000643662.1
    7. XM_017006484.2XP_016861973.1  plasma membrane calcium-transporting ATPase 2 isoform X2

      UniProtKB/Swiss-Prot
      Q01814
      Conserved Domains (7) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161457
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8721050
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10951142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:659798
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:518607
      Cation_ATPase; Cation transport ATPase (P-type)
    8. XM_006713175.4XP_006713238.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_006713238.1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    9. XM_017006481.2XP_016861970.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    10. XM_005265179.5XP_005265236.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_005265236.1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    11. XM_011533752.3XP_011532054.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_011532054.1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Related
      ENSP00000494716.1, ENST00000645850.1
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
    12. XM_017006483.2XP_016861972.1  plasma membrane calcium-transporting ATPase 2 isoform X2

      UniProtKB/Swiss-Prot
      Q01814
      Related
      ENSP00000414854.2, ENST00000452124.2
      Conserved Domains (7) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161457
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8721050
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10951142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:659798
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:518607
      Cation_ATPase; Cation transport ATPase (P-type)
    13. XM_017006482.2XP_016861971.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q01814
      UniProtKB/TrEMBL
      A0A024R2K6
      Conserved Domains (7) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:161488
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:9031081
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51113
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:11261173
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:690829
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:549638
      Cation_ATPase; Cation transport ATPase (P-type)
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