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Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 [ Mus musculus (house mouse) ]

Gene ID: 11941, updated on 5-Nov-2024

Summary

Official Symbol
Atp2b2provided by MGI
Official Full Name
ATPase, Ca++ transporting, plasma membrane 2provided by MGI
Primary source
MGI:MGI:105368
See related
Ensembl:ENSMUSG00000030302 AllianceGenome:MGI:105368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmy; dfw; jog; wms; wri; PMCA2; D6Abb2e; Gena300
Summary
Enables calcium-dependent ATPase activity. Involved in calcium ion transport; cochlea development; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; lactation; and neuron differentiation. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum; and neuronal cell body. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic membrane. Is expressed in heart; labyrinthine zone; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 49.9), cerebellum adult (RPKM 49.7) and 4 other tissues See more
Orthologs
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Genomic context

See Atp2b2 in Genome Data Viewer
Location:
6 E3; 6 52.85 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113720803..114019574, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113743831..114042613, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ghrelin Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene STARR-seq mESC enhancer starr_17054 Neighboring gene STARR-seq mESC enhancer starr_17055 Neighboring gene predicted gene 15083 Neighboring gene STARR-seq mESC enhancer starr_17060 Neighboring gene predicted gene, 36023 Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Neighboring gene predicted gene, 52916

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables P-type calcium transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables P-type calcium transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables P-type calcium transporter activity TAS
Traceable Author Statement
more info
 
enables P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-dependent ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cGMP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar granule cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within organelle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within otolith mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of sound ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within serotonin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
plasma membrane calcium-transporting ATPase 2
Names
deaf waddler
plasma membrane calcium ATPase
plasma membrane calcium pump
wriggle
NP_001031761.1
NP_001334294.1
NP_001396452.1
NP_001396453.1
NP_001396455.1
NP_001396458.1
NP_001396462.1
NP_001396463.1
NP_001396464.1
NP_001396465.1
NP_001396466.1
NP_033853.1
XP_011239463.1
XP_011239464.1
XP_011239468.1
XP_011239469.1
XP_011239470.1
XP_011239471.1
XP_011239472.1
XP_030110979.1
XP_030110980.1
XP_030110982.1
XP_036021655.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001036684.4NP_001031761.1  plasma membrane calcium-transporting ATPase 2 isoform 1

    See identical proteins and their annotated locations for NP_001031761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 3. These differences result in a shorter protein (isoform 1), compared to isoform 2. Variants 1, 2, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AC117596
    Consensus CDS
    CCDS20433.1
    UniProtKB/Swiss-Prot
    O88863, Q9R0K7
    UniProtKB/TrEMBL
    D5L240, Q3UHJ3
    Related
    ENSMUSP00000086398.6, ENSMUST00000089003.12
    Conserved Domains (2) summary
    TIGR01517
    Location:121042
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10811127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  2. NM_001347365.2NP_001334294.1  plasma membrane calcium-transporting ATPase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 2. Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC117596, AC153590
    Consensus CDS
    CCDS85130.1
    UniProtKB/TrEMBL
    D5L240, F8WHB1
    Related
    ENSMUSP00000098605.3, ENSMUST00000101044.9
    Conserved Domains (2) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11261172
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  3. NM_001409523.1NP_001396452.1  plasma membrane calcium-transporting ATPase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117596
    UniProtKB/TrEMBL
    F8WHB1
  4. NM_001409524.1NP_001396453.1  plasma membrane calcium-transporting ATPase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153590
  5. NM_001409526.1NP_001396455.1  plasma membrane calcium-transporting ATPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153590
    UniProtKB/Swiss-Prot
    O88863, Q9R0K7
    UniProtKB/TrEMBL
    Q3UHJ3
  6. NM_001409529.1NP_001396458.1  plasma membrane calcium-transporting ATPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153590
    UniProtKB/Swiss-Prot
    O88863, Q9R0K7
    UniProtKB/TrEMBL
    Q3UHJ3
  7. NM_001409533.1NP_001396462.1  plasma membrane calcium-transporting ATPase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117596
    UniProtKB/TrEMBL
    Q3UHH0
    Related
    ENSMUSP00000145174.2, ENSMUST00000205052.3
  8. NM_001409534.1NP_001396463.1  plasma membrane calcium-transporting ATPase 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117596
  9. NM_001409535.1NP_001396464.1  plasma membrane calcium-transporting ATPase 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC117596
  10. NM_001409536.1NP_001396465.1  plasma membrane calcium-transporting ATPase 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC117596
    UniProtKB/TrEMBL
    S4R1C4
  11. NM_001409537.1NP_001396466.1  plasma membrane calcium-transporting ATPase 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC117596
    UniProtKB/TrEMBL
    S4R1C4
  12. NM_009723.7NP_033853.1  plasma membrane calcium-transporting ATPase 2 isoform 1

    See identical proteins and their annotated locations for NP_033853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 3. These differences result in a shorter protein (isoform 1), compared to isoform 2. Variants 1, 2, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AC117596, AC153590
    Consensus CDS
    CCDS20433.1
    UniProtKB/Swiss-Prot
    O88863, Q9R0K7
    UniProtKB/TrEMBL
    D5L240, Q3UHJ3
    Related
    ENSMUSP00000098606.4, ENSMUST00000101045.10
    Conserved Domains (2) summary
    TIGR01517
    Location:121042
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10811127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RNA

  1. NR_176856.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117596, AC153590

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113720803..114019574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241161.1XP_011239463.1  plasma membrane calcium-transporting ATPase 2 isoform X1

    See identical proteins and their annotated locations for XP_011239463.1

    UniProtKB/TrEMBL
    D5L240, F8WHB1
    Conserved Domains (2) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11261172
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  2. XM_011241167.3XP_011239469.1  plasma membrane calcium-transporting ATPase 2 isoform X4

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11261168
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  3. XM_011241168.2XP_011239470.1  plasma membrane calcium-transporting ATPase 2 isoform X5

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11261168
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  4. XM_030255122.2XP_030110982.1  plasma membrane calcium-transporting ATPase 2 isoform X10

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11261201
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  5. XM_011241162.4XP_011239464.1  plasma membrane calcium-transporting ATPase 2 isoform X1

    See identical proteins and their annotated locations for XP_011239464.1

    UniProtKB/TrEMBL
    D5L240, F8WHB1
    Conserved Domains (2) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11261172
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  6. XM_011241166.4XP_011239468.1  plasma membrane calcium-transporting ATPase 2 isoform X3

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121056
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10951141
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  7. XM_030255120.2XP_030110980.1  plasma membrane calcium-transporting ATPase 2 isoform X3

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121056
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10951141
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  8. XM_030255119.2XP_030110979.1  plasma membrane calcium-transporting ATPase 2 isoform X2

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121073
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:11121158
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  9. XM_036165762.1XP_036021655.1  plasma membrane calcium-transporting ATPase 2 isoform X9

    UniProtKB/TrEMBL
    D5L240, S4R1C4
    Related
    ENSMUSP00000138165.2, ENSMUST00000152831.8
    Conserved Domains (2) summary
    TIGR01517
    Location:121042
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10811123
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  10. XM_011241170.2XP_011239472.1  plasma membrane calcium-transporting ATPase 2 isoform X8

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121042
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10811123
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
  11. XM_011241169.3XP_011239471.1  plasma membrane calcium-transporting ATPase 2 isoform X7

    UniProtKB/TrEMBL
    D5L240
    Conserved Domains (2) summary
    TIGR01517
    Location:121056
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:10951137
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RNA

  1. XR_868849.2 RNA Sequence

  2. XR_001785094.3 RNA Sequence