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    HSP90AB1 heat shock protein 90 alpha family class B member 1 [ Homo sapiens (human) ]

    Gene ID: 3326, updated on 11-Apr-2024

    Summary

    Official Symbol
    HSP90AB1provided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class B member 1provided by HGNC
    Primary source
    HGNC:HGNC:5258
    See related
    Ensembl:ENSG00000096384 MIM:140572; AllianceGenome:HGNC:5258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP84; HSPC2; HSPCB; D6S182; HSP90B
    Summary
    This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    6p21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (44246194..44253883)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (44080360..44088031)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44213931..44221620)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene ReSE screen-validated silencer GRCh37_chr6:44181066-44181247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44184149-44185034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44185035-44185920 Neighboring gene Sharpr-MPRA regulatory region 7869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44191161-44192019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44194558-44195156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17259 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44214649-44215403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44213140-44213894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24632 Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44224854-44225567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44222709-44223424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44232415-44232914 Neighboring gene solute carrier family 29 member 1 (Augustine blood group) Neighboring gene myomixer, myoblast fusion factor Neighboring gene microRNA 4647 Neighboring gene solute carrier family 35 member B2 Neighboring gene NFKB inhibitor epsilon

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
    Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
    tat Expression of HIV-1 Tat upregulates the abundance of heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock protein 90kDa, class B member 1 (HSP90AB1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    capsid gag Reduced infectivity of HIV-1 CA mutants can be rescued by HSP90AB1 overexpression. Hyperthermia-induced expression of HSP90AB1 rescues CA-mutant infectivity in nonactivated cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1: beta; 84 kDa) at amino acid residues 483-484 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26984

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP hydrolysis activity TAS
    Traceable Author Statement
    more info
     
    enables ATP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables MHC class II protein complex binding HDA PubMed 
    enables RNA binding HDA PubMed 
    enables TPR domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cadherin binding HDA PubMed 
    enables disordered domain specific binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone methyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nitric-oxide synthase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone-mediated protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cyclin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tau-protein kinase activity IC
    Inferred by Curator
    more info
     
    involved_in positive regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in supramolecular fiber organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomerase holoenzyme complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in virion attachment to host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of HSP90-CDC37 chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of aryl hydrocarbon receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    heat shock protein HSP 90-beta
    Names
    HSP90-beta
    heat shock 84 kDa
    heat shock 90kD protein 1, beta
    heat shock protein 90 kDa
    heat shock protein 90kDa alpha (cytosolic), class B member 1
    heat shock protein 90kDa alpha family class B member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271969.2NP_001258898.1  heat shock protein HSP 90-beta isoform a

      See identical proteins and their annotated locations for NP_001258898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AY359878, BQ028821
      Consensus CDS
      CCDS4909.1
      UniProtKB/Swiss-Prot
      B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
      UniProtKB/TrEMBL
      B4DGL0
      Related
      ENSP00000325875.3, ENST00000353801.7
      Conserved Domains (1) summary
      PTZ00272
      Location:14724
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    2. NM_001271970.2NP_001258899.1  heat shock protein HSP 90-beta isoform a

      See identical proteins and their annotated locations for NP_001258899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
      Source sequence(s)
      BC004928, BE539681, BX420114, DC341882
      Consensus CDS
      CCDS4909.1
      UniProtKB/Swiss-Prot
      B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
      UniProtKB/TrEMBL
      B4DGL0
      Related
      ENSP00000481908.1, ENST00000620073.4
      Conserved Domains (1) summary
      PTZ00272
      Location:14724
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    3. NM_001271971.2NP_001258900.1  heat shock protein HSP 90-beta isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and two alternate in-frame splice sides in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
      Source sequence(s)
      BC004928, BE539681, BG482327, DC350708
      UniProtKB/TrEMBL
      B4DGL0
      Conserved Domains (2) summary
      PTZ00272
      Location:14676
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:143666
      HSP90; Hsp90 protein
    4. NM_001271972.2NP_001258901.1  heat shock protein HSP 90-beta isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and uses an alternate in-frame splice site in the internal coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
      Source sequence(s)
      AK294643, BC007327, BE539681
      UniProtKB/TrEMBL
      B4DGL0
      Conserved Domains (3) summary
      PTZ00272
      Location:14714
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:181704
      HSP90; Hsp90 protein
      pfam02518
      Location:40178
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    5. NM_001371238.1NP_001358167.1  heat shock protein HSP 90-beta isoform a

      Status: REVIEWED

      Source sequence(s)
      AL139392
      Consensus CDS
      CCDS4909.1
      UniProtKB/Swiss-Prot
      B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
      UniProtKB/TrEMBL
      B4DGL0
      Related
      ENSP00000360609.1, ENST00000371554.2
      Conserved Domains (1) summary
      PTZ00272
      Location:14724
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    6. NM_007355.4NP_031381.2  heat shock protein HSP 90-beta isoform a

      See identical proteins and their annotated locations for NP_031381.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
      Source sequence(s)
      BC004928, BE539681, DC340766
      Consensus CDS
      CCDS4909.1
      UniProtKB/Swiss-Prot
      B2R5P0, P08238, Q5T9W7, Q9NQW0, Q9NTK6
      UniProtKB/TrEMBL
      B4DGL0
      Related
      ENSP00000360709.5, ENST00000371646.10
      Conserved Domains (1) summary
      PTZ00272
      Location:14724
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      44246194..44253883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      44080360..44088031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_073528.1: Suppressed sequence

      Description
      NR_073528.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.