Ptk7 protein tyrosine kinase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptk7provided by RGD
Official Full Name: protein tyrosine kinase 7provided by RGD
Primary source: RGD:1310472
See related: EnsemblRapid:ENSRNOG00000039976 AllianceGenome:RGD:1310472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including actin cytoskeleton reorganization; cellular response to retinoic acid; and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; axis elongation; and morphogenesis of an epithelium. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 114.4), Uterus (RPKM 97.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (21849756..21916077)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (14352155..14418473)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (16662588..16729888)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132300 (e-PCR)
- UniSTS:215583

RH127795 (e-PCR)
- UniSTS:211105

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axis elongation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within convergent extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of planar polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung-associated mesenchyme development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive tyrosine-protein kinase 7

Names: PTK7 protein tyrosine kinase 7; tyrosine-protein kinase-like 7

NP_001382670.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395741.1 → NP_001382670.1 inactive tyrosine-protein kinase 7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AKN3, A0A8I6ALM9

Related

ENSRNOP00000094298.1, ENSRNOT00000108486.2

Conserved Domains (5) summary

cd05046
Location:782 → 1055

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

pfam13927
Location:585 → 660

Ig_3; Immunoglobulin domain

cd00096
Location:592 → 595

Ig; Ig strand A' [structural motif]

cd05760
Location:120 → 214

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7

cl11960
Location:404 → 490

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

21849756..21916077

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106889.2: Suppressed sequence

Description

NM_001106889.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.