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    GOLGA2 golgin A2 [ Homo sapiens (human) ]

    Gene ID: 2801, updated on 8-Jan-2023

    Summary

    Official Symbol
    GOLGA2provided by HGNC
    Official Full Name
    golgin A2provided by HGNC
    Primary source
    HGNC:HGNC:4425
    See related
    Ensembl:ENSG00000167110 MIM:602580; AllianceGenome:HGNC:4425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GM130
    Summary
    The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in prostate (RPKM 18.6), esophagus (RPKM 17.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GOLGA2 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128255829..128276007, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140462943..140483121, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131018108..131038286, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene dynamin 1 Neighboring gene microRNA 199b Neighboring gene microRNA 3154 Neighboring gene SWI5 homologous recombination repair protein Neighboring gene Sharpr-MPRA regulatory region 12606 Neighboring gene Sharpr-MPRA regulatory region 14380 Neighboring gene TruB pseudouridine synthase family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Genome-wide shRNA screening identifies GOLGA2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    nef HIV-1 Nef causes the FMS N-glycosylation defect and induces relocalization of the GM130 by activating the p56Hck/MEK/ERK/GRASP65 phosphorylation cascade in the Golgi PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC20672

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables importin-alpha family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Golgi organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in Golgi ribbon formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in centrosome cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in meiotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi cisterna membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cis-Golgi network NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    golgin subfamily A member 2
    Names
    130 kDa cis-Golgi matrix protein
    GM130 autoantigen
    Golgi matrix protein GM130
    SY11 protein
    golgi autoantigen, golgin subfamily a, 2
    golgin-95

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366244.2NP_001353173.2  golgin subfamily A member 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Consensus CDS
      CCDS94495.1
      UniProtKB/TrEMBL
      A0A8J9BZL8
      Related
      ENSP00000478799.2, ENST00000611957.5
      Conserved Domains (3) summary
      COG1196
      Location:183473
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:408935
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:9801025
      GM130_C; GM130 C-terminal binding motif
    2. NM_001366246.2NP_001353175.2  golgin subfamily A member 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Consensus CDS
      CCDS94494.1
      UniProtKB/TrEMBL
      A0A8I5KZ68
      Related
      ENSP00000510790.1, ENST00000687179.1
      Conserved Domains (3) summary
      TIGR02168
      Location:178445
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15070
      Location:381908
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:953998
      GM130_C; GM130 C-terminal binding motif
    3. NM_001389695.2NP_001376624.2  golgin subfamily A member 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      COG1196
      Location:187468
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:403930
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:9751020
      GM130_C; GM130 C-terminal binding motif
    4. NM_001389696.2NP_001376625.2  golgin subfamily A member 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      COG1196
      Location:183500
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:408929
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:9741019
      GM130_C; GM130 C-terminal binding motif
    5. NM_001389697.2NP_001376626.2  golgin subfamily A member 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      TIGR02168
      Location:152441
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15070
      Location:377904
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:949994
      GM130_C; GM130 C-terminal binding motif
    6. NM_001389698.2NP_001376627.2  golgin subfamily A member 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      COG0419
      Location:187554
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15070
      Location:381902
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:947992
      GM130_C; GM130 C-terminal binding motif
    7. NM_001389699.2NP_001376628.2  golgin subfamily A member 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Consensus CDS
      CCDS94493.1
      UniProtKB/TrEMBL
      A0A8I5QJQ7
      Related
      ENSP00000510145.1, ENST00000686291.1
      Conserved Domains (3) summary
      COG1196
      Location:186433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:368895
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:940985
      GM130_C; GM130 C-terminal binding motif
    8. NM_001389700.2NP_001376629.2  golgin subfamily A member 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      TIGR02168
      Location:154432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15070
      Location:368895
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:940985
      GM130_C; GM130 C-terminal binding motif
    9. NM_001389701.2NP_001376630.2  golgin subfamily A member 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Consensus CDS
      CCDS94492.1
      UniProtKB/TrEMBL
      A0A8I5KNZ1
      Related
      ENSP00000508841.1, ENST00000693185.1
      Conserved Domains (3) summary
      TIGR02168
      Location:151418
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15070
      Location:354881
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:926971
      GM130_C; GM130 C-terminal binding motif
    10. NM_001389702.2NP_001376631.2  golgin subfamily A member 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      COG1196
      Location:121411
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:346873
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:918963
      GM130_C; GM130 C-terminal binding motif
    11. NM_001389703.2NP_001376632.2  golgin subfamily A member 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      COG1196
      Location:159406
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:341868
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:913958
      GM130_C; GM130 C-terminal binding motif
    12. NM_001389704.2NP_001376633.2  golgin subfamily A member 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Conserved Domains (3) summary
      COG1196
      Location:70355
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:263784
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:829874
      GM130_C; GM130 C-terminal binding motif
    13. NM_001389705.2NP_001376634.2  golgin subfamily A member 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Related
      ENSP00000481685.2, ENST00000610329.5
      Conserved Domains (3) summary
      COG1196
      Location:92348
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:250777
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:822867
      GM130_C; GM130 C-terminal binding motif
    14. NM_004486.6NP_004477.5  golgin subfamily A member 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL590708
      Consensus CDS
      CCDS6896.2
      UniProtKB/Swiss-Prot
      Q9NYF9
      Related
      ENSP00000416097.4, ENST00000421699.8
      Conserved Domains (3) summary
      COG1196
      Location:156446
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:381908
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
      pfam19046
      Location:953998
      GM130_C; GM130 C-terminal binding motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      128255829..128276007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      140462943..140483121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)