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    CHD3 chromodomain helicase DNA binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 1107, updated on 5-May-2024

    Summary

    Official Symbol
    CHD3provided by HGNC
    Official Full Name
    chromodomain helicase DNA binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:1918
    See related
    Ensembl:ENSG00000170004 MIM:602120; AllianceGenome:HGNC:1918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFH; Mi-2a; SNIBCPS; Mi2-ALPHA
    Summary
    This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 26.5), brain (RPKM 24.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CHD3 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7884796..7912755)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7790128..7818165)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7788114..7816073)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7759303-7759840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11650 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7760574-7761436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7761437-7762298 Neighboring gene transmembrane protein 88 Neighboring gene N-alpha-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7792539-7793108 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:7797066-7798265 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806009-7806616 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806617-7807223 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7818325-7819258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8148 Neighboring gene ring finger protein 227 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with CHD3 as demonstrated by proximity dependent biotinylation proteomics PubMed
    Tat tat Depletion of CHD3 results in derepression of latent HIV-1 LTR activity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent chromatin remodeler activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding HDA PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables helicase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NuRD complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of NuRD complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    chromodomain-helicase-DNA-binding protein 3
    Names
    ATP-dependent helicase CHD3
    CHD-3
    hZFH
    mi-2 autoantigen 240 kDa protein
    zinc finger helicase
    zinc-finger helicase (Snf2-like)
    NP_001005271.2
    NP_001005273.1
    NP_005843.2
    XP_005256484.1
    XP_005256485.1
    XP_005256486.1
    XP_005256488.1
    XP_006721486.1
    XP_006721487.1
    XP_006721491.1
    XP_016879552.1
    XP_016879553.1
    XP_016879554.1
    XP_016879555.2
    XP_016879556.1
    XP_016879557.1
    XP_016879558.1
    XP_047291146.1
    XP_047291147.1
    XP_047291148.1
    XP_047291149.1
    XP_047291150.1
    XP_047291151.1
    XP_047291152.1
    XP_047291153.1
    XP_047291154.1
    XP_047291155.1
    XP_047291156.1
    XP_047291157.1
    XP_047291158.1
    XP_047291159.1
    XP_047291160.1
    XP_047291161.1
    XP_047291162.1
    XP_047291163.1
    XP_047291164.1
    XP_047291165.1
    XP_047291166.1
    XP_047291167.1
    XP_047291168.1
    XP_047291169.1
    XP_047291170.1
    XP_047291171.1
    XP_047291172.1
    XP_054170787.1
    XP_054170788.1
    XP_054170789.1
    XP_054170790.1
    XP_054170791.1
    XP_054170792.1
    XP_054170793.1
    XP_054170794.1
    XP_054170795.1
    XP_054170796.1
    XP_054170797.1
    XP_054170798.1
    XP_054170799.1
    XP_054170800.1
    XP_054170801.1
    XP_054170802.1
    XP_054170803.1
    XP_054170804.1
    XP_054170805.1
    XP_054170806.1
    XP_054170807.1
    XP_054170808.1
    XP_054170809.1
    XP_054170810.1
    XP_054170811.1
    XP_054170812.1
    XP_054170813.1
    XP_054170814.1
    XP_054170815.1
    XP_054170816.1
    XP_054170817.1
    XP_054170818.1
    XP_054170819.1
    XP_054170820.1
    XP_054170821.1
    XP_054170822.1
    XP_054170823.1
    XP_054170824.1
    XP_054170825.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005271.3NP_001005271.2  chromodomain-helicase-DNA-binding protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and CDS, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct N-terminus, compared to isoform 1. The transcript is supported by ESTs and an mRNA but the predicted protein has not yet been confirmed experimentally.
      Source sequence(s)
      AC104581, AF064844, AK125928, BC110648, BX283837, U91543
      Consensus CDS
      CCDS32553.2
      UniProtKB/Swiss-Prot
      Q12873
      UniProtKB/TrEMBL
      B3KWV4, Q2TAZ1
      Related
      ENSP00000369716.4, ENST00000380358.9
      Conserved Domains (11) summary
      smart00298
      Location:692744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11181233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:14371576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17951966
      CHDCT2; CHDCT2 (NUC038) domain
    2. NM_001005273.3NP_001005273.1  chromodomain-helicase-DNA-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001005273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variant 1 encodes isoform 1.
      Source sequence(s)
      AC104581, AK125928, BC110648, U91543
      Consensus CDS
      CCDS32554.1
      UniProtKB/Swiss-Prot
      D3DTQ9, E9PG89, Q12873, Q9Y4I0
      Related
      ENSP00000332628.7, ENST00000330494.12
      Conserved Domains (11) summary
      smart00298
      Location:633685
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:8791258
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:756914
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:381423
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:458500
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7391035
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10591174
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:13781517
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13121356
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:148200
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17361907
      CHDCT2; CHDCT2 (NUC038) domain
    3. NM_005852.4NP_005843.2  chromodomain-helicase-DNA-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_005843.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC104581, AK125928, BC110648, U91543
      Consensus CDS
      CCDS32555.1
      UniProtKB/Swiss-Prot
      Q12873
      UniProtKB/TrEMBL
      B3KWV4, Q2TAZ1
      Related
      ENSP00000350907.4, ENST00000358181.8
      Conserved Domains (12) summary
      PHA03418
      Location:15191654
      PHA03418; hypothetical E4 protein; Provisional
      smart00298
      Location:633685
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:8791258
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:756914
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:381423
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:458500
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7391035
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10591174
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:13781517
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13121356
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:148200
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17021873
      CHDCT2; CHDCT2 (NUC038) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7884796..7912755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256427.5XP_005256484.1  chromodomain-helicase-DNA-binding protein 3 isoform X1

      Conserved Domains (11) summary
      smart00298
      Location:692744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11181233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:14371576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17961923
      CHDCT2; CHDCT2 (NUC038) domain
    2. XM_005256429.5XP_005256486.1  chromodomain-helicase-DNA-binding protein 3 isoform X7

      Conserved Domains (11) summary
      smart00298
      Location:692744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11181233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:14371576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17961967
      CHDCT2; CHDCT2 (NUC038) domain
    3. XM_006721423.4XP_006721486.1  chromodomain-helicase-DNA-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TR54
      Related
      ENSP00000515165.1, ENST00000700753.1
      Conserved Domains (11) summary
      smart00298
      Location:692744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11181233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:14371576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17951922
      CHDCT2; CHDCT2 (NUC038) domain
    4. XM_005256428.5XP_005256485.1  chromodomain-helicase-DNA-binding protein 3 isoform X5

      Conserved Domains (12) summary
      PHA03418
      Location:15781713
      PHA03418; hypothetical E4 protein; Provisional
      smart00298
      Location:692744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11181233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:14371576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17611888
      CHDCT2; CHDCT2 (NUC038) domain
    5. XM_006721428.4XP_006721491.1  chromodomain-helicase-DNA-binding protein 3 isoform X22

      Conserved Domains (12) summary
      PHA03418
      Location:15781713
      PHA03418; hypothetical E4 protein; Provisional
      smart00298
      Location:692744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:9381317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11181233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:14371576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13711415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17611932
      CHDCT2; CHDCT2 (NUC038) domain
    6. XM_017024065.2XP_016879554.1  chromodomain-helicase-DNA-binding protein 3 isoform X14

    7. XM_047435206.1XP_047291162.1  chromodomain-helicase-DNA-binding protein 3 isoform X27

    8. XM_047435196.1XP_047291152.1  chromodomain-helicase-DNA-binding protein 3 isoform X15

    9. XM_047435207.1XP_047291163.1  chromodomain-helicase-DNA-binding protein 3 isoform X28

    10. XM_047435213.1XP_047291169.1  chromodomain-helicase-DNA-binding protein 3 isoform X34

    11. XM_006721424.4XP_006721487.1  chromodomain-helicase-DNA-binding protein 3 isoform X3

      Conserved Domains (11) summary
      smart00298
      Location:688740
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:9341313
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:811969
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:436478
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:513555
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7941090
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11141229
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:14331572
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13671411
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17921919
      CHDCT2; CHDCT2 (NUC038) domain
    12. XM_047435192.1XP_047291148.1  chromodomain-helicase-DNA-binding protein 3 isoform X8

    13. XM_047435190.1XP_047291146.1  chromodomain-helicase-DNA-binding protein 3 isoform X4

    14. XM_017024064.2XP_016879553.1  chromodomain-helicase-DNA-binding protein 3 isoform X10

    15. XM_047435191.1XP_047291147.1  chromodomain-helicase-DNA-binding protein 3 isoform X6

    16. XM_047435202.1XP_047291158.1  chromodomain-helicase-DNA-binding protein 3 isoform X23

    17. XM_047435198.1XP_047291154.1  chromodomain-helicase-DNA-binding protein 3 isoform X18

    18. XM_047435208.1XP_047291164.1  chromodomain-helicase-DNA-binding protein 3 isoform X29

    19. XM_047435214.1XP_047291170.1  chromodomain-helicase-DNA-binding protein 3 isoform X35

    20. XM_005256431.5XP_005256488.1  chromodomain-helicase-DNA-binding protein 3 isoform X38

      UniProtKB/TrEMBL
      A0A5F9ZHX5
      Conserved Domains (7) summary
      smart00298
      Location:692744
      CHROMO; Chromatin organization modifier domain
      cd00046
      Location:815973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7981094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:11181185
      Helicase_C; Helicase conserved C-terminal domain
      pfam08073
      Location:207259
      CHDNT; CHDNT (NUC034) domain
    21. XM_047435210.1XP_047291166.1  chromodomain-helicase-DNA-binding protein 3 isoform X31

    22. XM_017024067.3XP_016879556.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

      Conserved Domains (11) summary
      smart00298
      Location:622674
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:8681247
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:745903
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:370412
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:447489
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7281024
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10481163
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:13671506
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:13011345
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:137189
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17261853
      CHDCT2; CHDCT2 (NUC038) domain
    23. XM_017024068.2XP_016879557.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

      Conserved Domains (11) summary
      smart00298
      Location:613665
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:8591238
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:736894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:361403
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:438480
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:7191015
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10391154
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:13581497
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:12921336
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:128180
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:17171844
      CHDCT2; CHDCT2 (NUC038) domain
    24. XM_047435211.1XP_047291167.1  chromodomain-helicase-DNA-binding protein 3 isoform X32

    25. XM_047435204.1XP_047291160.1  chromodomain-helicase-DNA-binding protein 3 isoform X25

    26. XM_047435197.1XP_047291153.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

    27. XM_047435199.1XP_047291155.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

    28. XM_047435209.1XP_047291165.1  chromodomain-helicase-DNA-binding protein 3 isoform X30

    29. XM_047435200.1XP_047291156.1  chromodomain-helicase-DNA-binding protein 3 isoform X20

    30. XM_047435201.1XP_047291157.1  chromodomain-helicase-DNA-binding protein 3 isoform X21

    31. XM_047435215.1XP_047291171.1  chromodomain-helicase-DNA-binding protein 3 isoform X36

    32. XM_047435216.1XP_047291172.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

    33. XM_017024066.2XP_016879555.2  chromodomain-helicase-DNA-binding protein 3 isoform X16

    34. XM_017024069.2XP_016879558.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

    35. XM_017024063.2XP_016879552.1  chromodomain-helicase-DNA-binding protein 3 isoform X9

    36. XM_047435193.1XP_047291149.1  chromodomain-helicase-DNA-binding protein 3 isoform X11

    37. XM_047435194.1XP_047291150.1  chromodomain-helicase-DNA-binding protein 3 isoform X12

    38. XM_047435203.1XP_047291159.1  chromodomain-helicase-DNA-binding protein 3 isoform X24

    39. XM_047435195.1XP_047291151.1  chromodomain-helicase-DNA-binding protein 3 isoform X13

    40. XM_047435205.1XP_047291161.1  chromodomain-helicase-DNA-binding protein 3 isoform X26

    41. XM_047435212.1XP_047291168.1  chromodomain-helicase-DNA-binding protein 3 isoform X33

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7790128..7818165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314812.1XP_054170787.1  chromodomain-helicase-DNA-binding protein 3 isoform X1

    2. XM_054314818.1XP_054170793.1  chromodomain-helicase-DNA-binding protein 3 isoform X7

    3. XM_054314813.1XP_054170788.1  chromodomain-helicase-DNA-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TR54
    4. XM_054314816.1XP_054170791.1  chromodomain-helicase-DNA-binding protein 3 isoform X5

    5. XM_054314834.1XP_054170809.1  chromodomain-helicase-DNA-binding protein 3 isoform X22

    6. XM_054314825.1XP_054170800.1  chromodomain-helicase-DNA-binding protein 3 isoform X14

    7. XM_054314839.1XP_054170814.1  chromodomain-helicase-DNA-binding protein 3 isoform X27

    8. XM_054314826.1XP_054170801.1  chromodomain-helicase-DNA-binding protein 3 isoform X15

    9. XM_054314840.1XP_054170815.1  chromodomain-helicase-DNA-binding protein 3 isoform X28

    10. XM_054314846.1XP_054170821.1  chromodomain-helicase-DNA-binding protein 3 isoform X34

    11. XM_054314814.1XP_054170789.1  chromodomain-helicase-DNA-binding protein 3 isoform X3

    12. XM_054314819.1XP_054170794.1  chromodomain-helicase-DNA-binding protein 3 isoform X8

    13. XM_054314815.1XP_054170790.1  chromodomain-helicase-DNA-binding protein 3 isoform X4

    14. XM_054314821.1XP_054170796.1  chromodomain-helicase-DNA-binding protein 3 isoform X10

    15. XM_054314817.1XP_054170792.1  chromodomain-helicase-DNA-binding protein 3 isoform X6

    16. XM_054314835.1XP_054170810.1  chromodomain-helicase-DNA-binding protein 3 isoform X23

    17. XM_054314829.1XP_054170804.1  chromodomain-helicase-DNA-binding protein 3 isoform X18

    18. XM_054314841.1XP_054170816.1  chromodomain-helicase-DNA-binding protein 3 isoform X29

    19. XM_054314847.1XP_054170822.1  chromodomain-helicase-DNA-binding protein 3 isoform X35

    20. XM_054314850.1XP_054170825.1  chromodomain-helicase-DNA-binding protein 3 isoform X38

    21. XM_054314843.1XP_054170818.1  chromodomain-helicase-DNA-binding protein 3 isoform X31

    22. XM_054314831.1XP_054170806.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

    23. XM_054314830.1XP_054170805.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

    24. XM_054314844.1XP_054170819.1  chromodomain-helicase-DNA-binding protein 3 isoform X32

    25. XM_054314837.1XP_054170812.1  chromodomain-helicase-DNA-binding protein 3 isoform X25

    26. XM_054314842.1XP_054170817.1  chromodomain-helicase-DNA-binding protein 3 isoform X30

    27. XM_054314832.1XP_054170807.1  chromodomain-helicase-DNA-binding protein 3 isoform X20

    28. XM_054314833.1XP_054170808.1  chromodomain-helicase-DNA-binding protein 3 isoform X21

    29. XM_054314848.1XP_054170823.1  chromodomain-helicase-DNA-binding protein 3 isoform X36

    30. XM_054314828.1XP_054170803.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

    31. XM_054314849.1XP_054170824.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

    32. XM_054314820.1XP_054170795.1  chromodomain-helicase-DNA-binding protein 3 isoform X9

    33. XM_054314822.1XP_054170797.1  chromodomain-helicase-DNA-binding protein 3 isoform X11

    34. XM_054314823.1XP_054170798.1  chromodomain-helicase-DNA-binding protein 3 isoform X12

    35. XM_054314836.1XP_054170811.1  chromodomain-helicase-DNA-binding protein 3 isoform X24

    36. XM_054314824.1XP_054170799.1  chromodomain-helicase-DNA-binding protein 3 isoform X13

    37. XM_054314838.1XP_054170813.1  chromodomain-helicase-DNA-binding protein 3 isoform X26

    38. XM_054314845.1XP_054170820.1  chromodomain-helicase-DNA-binding protein 3 isoform X33

    39. XM_054314827.1XP_054170802.1  chromodomain-helicase-DNA-binding protein 3 isoform X39

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001272.1: Suppressed sequence

      Description
      NM_001272.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.