Il21r interleukin 21 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il21rprovided by RGD
Official Full Name: interleukin 21 receptorprovided by RGD
Primary source: RGD:1304950
See related: Ensembl:ENSRNOG00000015773 AllianceGenome:RGD:1304950
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in B-cell lymphoma (multiple); Crohn's disease; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and immunodeficiency 56. Orthologous to human IL21R (interleukin 21 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 327.4), Spleen (RPKM 159.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (189598682..189626340)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (180168028..180195690)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (196996405..197024185)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGMA and IL21R and their pathways are crucial in MS pathogenesis and warrant further studies as potential biomarkers and therapeutic targets
Title: RGMA and IL21R show association with experimental inflammation and multiple sclerosis.
expression is induced in intravascular monocytes in vivo in response to allogeneic kidney transplantation
Title: Expression of interleukin-21, interleukin-21 receptor alpha and related type I cytokines by intravascular graft leukocytes during acute renal allograft rejection.

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General gene information

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Markers

AU028119 (e-PCR)
- UniSTS:112640

AU048745 (e-PCR)
- UniSTS:145195

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-21 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012469.1 → NP_001012487.1 interleukin-21 receptor precursor

See identical proteins and their annotated locations for NP_001012487.1

Status: PROVISIONAL

Source sequence(s)

BC089857

UniProtKB/TrEMBL

A0A8I6ASZ0, A6I919, F7FPE1, Q5EBB1

Related

ENSRNOP00000021690.3, ENSRNOT00000021690.5

Conserved Domains (1) summary

cd00063
Location:120 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

189598682..189626340

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230261.5 → XP_006230323.1 interleukin-21 receptor isoform X1

See identical proteins and their annotated locations for XP_006230323.1

UniProtKB/TrEMBL

A0A8I6ASZ0, A6I919, F7FPE1, Q5EBB1

Related

ENSRNOP00000079649.1

Conserved Domains (1) summary

cd00063
Location:120 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...