U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il21r interleukin 21 receptor [ Mus musculus (house mouse) ]

Gene ID: 60504, updated on 10-Jan-2023

Summary

Official Symbol
Il21rprovided by MGI
Official Full Name
interleukin 21 receptorprovided by MGI
Primary source
MGI:MGI:1890475
See related
Ensembl:ENSMUSG00000030745 AllianceGenome:MGI:1890475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NILR
Summary
Enables cytokine receptor activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in lung; mandible; and orbito-sphenoid. Human ortholog(s) of this gene implicated in B-cell lymphoma (multiple); Crohn's disease; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and immunodeficiency 56. Orthologous to human IL21R (interleukin 21 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 55.0), thymus adult (RPKM 44.6) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Il21r in Genome Data Viewer
Location:
7; 7 F3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125202424..125232742)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (125603252..125634397)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene Neighboring gene interleukin 4 receptor, alpha Neighboring gene general transcription factor III C 1 Neighboring gene katanin interacting protein Neighboring gene VISTA enhancer mm174

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-21 receptor
Names
IL-21 receptor
IL-21R
LR-beta
NR8
lymphocyte receptor beta
novel cytokine receptor 8
novel interleukin receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021887.2NP_068687.1  interleukin-21 receptor precursor

    See identical proteins and their annotated locations for NP_068687.1

    Status: VALIDATED

    Source sequence(s)
    AC125213, AF254068, BB634399
    Consensus CDS
    CCDS21823.1
    UniProtKB/Swiss-Prot
    Q9ESM1, Q9JHX3
    UniProtKB/TrEMBL
    Q3TAI3
    Related
    ENSMUSP00000033000.7, ENSMUST00000033000.8
    Conserved Domains (1) summary
    cd00063
    Location:120225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    125202424..125232742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508097.5XP_006508160.1  interleukin-21 receptor isoform X1

    Conserved Domains (1) summary
    cd00063
    Location:123228
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_036153309.1XP_036009202.1  interleukin-21 receptor isoform X3

    Conserved Domains (1) summary
    cd00063
    Location:123228
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_036153310.1XP_036009203.1  interleukin-21 receptor isoform X4

    UniProtKB/TrEMBL
    Q6PEU8
    Related
    ENSMUSP00000145966.2, ENSMUST00000206103.2
    Conserved Domains (1) summary
    cd00063
    Location:120225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006508098.5XP_006508161.1  interleukin-21 receptor isoform X2

    Conserved Domains (1) summary
    cd00063
    Location:113218
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...