| H3K4me3 regulates RNA polymerase II promoter-proximal pause-release. | H3K4me3 regulates RNA polymerase II promoter-proximal pause-release.
Wang H, Fan Z, Shliaha PV, Miele M, Hendrickson RC, Jiang X, Helin K., Free PMC Article | 08/9/2023 |
| POLR2A blocks osteoclastic bone resorption and protects against osteoporosis by interacting with CREB1. | POLR2A blocks osteoclastic bone resorption and protects against osteoporosis by interacting with CREB1.
Liu C, Han Y, Zhao X, Li B, Xu L, Li D, Li G. | 10/16/2021 |
| Enhancers predominantly regulate gene expression during differentiation via transcription initiation. | Enhancers predominantly regulate gene expression during differentiation via transcription initiation.
Larke MSC, Schwessinger R, Nojima T, Telenius J, Beagrie RA, Downes DJ, Oudelaar AM, Truch J, Graham B, Bender MA, Proudfoot NJ, Higgs DR, Hughes JR., Free PMC Article | 03/20/2021 |
| Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements. | Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
Thomas HF, Kotova E, Jayaram S, Pilz A, Romeike M, Lackner A, Penz T, Bock C, Leeb M, Halbritter F, Wysocka J, Buecker C. | 03/20/2021 |
| Dysregulated RPB1 is a central oncogenic hub that drives overgrowth by hijacking an array of oncogenic and anti-apoptosis factors. | Aberrant activation of RPB1 is critical for cell overgrowth in acute myeloid leukemia.
Yu Q, Xu Y, Zhuang H, Wu Z, Zhang L, Li J, Yang L, Wu B, Wang P, Zhang X, Gan X, Liang Y, Zheng S, Yu X, Gu Y, Xu R. | 06/20/2020 |
| Crosstalk between RNA Pol II C-terminal domain acetylation and phosphorylation via RPRD1B protein and its isoforms has been reported. | Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M., Free PMC Article | 01/18/2020 |
| TBP promotes the association of RNA Polymerase II with mitotic chromosomes, and facilitates transcriptional reactivation following mitosis. | A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes.
Teves SS, An L, Bhargava-Shah A, Xie L, Darzacq X, Tjian R., Free PMC Article | 04/13/2019 |
| significantly higher binding of POLR2A to the Tmem132d promoter region of high anxiety behavior mice than in low anxiety behavior mice | Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.
Naik RR, Sotnikov SV, Diepold RP, Iurato S, Markt PO, Bultmann A, Brehm N, Mattheus T, Lutz B, Erhardt A, Binder EB, Schmidt U, Holsboer F, Landgraf R, Czibere L., Free PMC Article | 12/22/2018 |
| Skill learning modulates RNA Pol II poising at immediate early genes in the adult striatum. These experiments demonstrate a novel phenomenon of learning induced transcriptional modulation in adult brain. | Skill Learning Modulates RNA Pol II Poising at Immediate Early Genes in the Adult Striatum.
Galvão-Ferreira P, Lipinski M, Santos F, Barco A, Costa RM., Free PMC Article | 02/3/2018 |
| An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation. | An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.
Sabbattini P, Sjoberg M, Nikic S, Frangini A, Holmqvist PH, Kunowska N, Carroll T, Brookes E, Arthur SJ, Pombo A, Dillon N., Free PMC Article | 11/8/2014 |
| Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription | Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.
Guillamot M, Manchado E, Chiesa M, Gómez-López G, Pisano DG, Sacristán MP, Malumbres M., Free PMC Article | 09/14/2013 |
| These data indicate that, through cooperation with PolII and KDM6A, Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation. | The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.
Wang AH, Zare H, Mousavi K, Wang C, Moravec CE, Sirotkin HI, Ge K, Gutierrez-Cruz G, Sartorelli V., Free PMC Article | 06/22/2013 |
| site-specific p65 phosphorylation targets NF-kappaB activity to particular gene subsets on a global level by influencing p65 and p-RNAP II promoter recruitment | Site-specific phosphorylation of the p65 protein subunit mediates selective gene expression by differential NF-κB and RNA polymerase II promoter recruitment.
Hochrainer K, Racchumi G, Anrather J., Free PMC Article | 03/2/2013 |
| Data show that that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH. | B2 RNA represses TFIIH phosphorylation of RNA polymerase II.
Yakovchuk P, Goodrich JA, Kugel JF., Free PMC Article | 06/23/2012 |
| investigation of contribution of largest subunit of phosphorylated RNAP II to onset of minor gene activation in zygote; nuclear localization of RNAP II in 1-cell zygote; regulation of RNAP II expression by deposition of acetylated histone on promoter | Deposition of acetylated histones by RNAP II promoter clearance may occur at onset of zygotic gene activation in preimplantation mouse embryos.
Tokoro M, Shin SW, Nishikawa S, Lee HH, Hatanaka Y, Amano T, Mitani T, Kato H, Anzai M, Kishigami S, Saeki K, Hosoi Y, Iritani A, Matsumoto K. | 05/21/2011 |
| involvement of RPB1, the largest subunit of RNA polymerase II (RNAP II), in the regulation of transcriptional silencing mechanism | Global gene silencing is caused by the dissociation of RNA polymerase II from DNA in mouse oocytes.
ABE K, INOUE A, SUZUKI MG, AOKI F. | 12/11/2010 |
| These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.[Rpb1] | Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells.
Li H, Zhang Z, Wang B, Zhang J, Zhao Y, Jin Y., Free PMC Article | 01/21/2010 |
| The authors that both the ubiquitylation and proteasomal degradation of the largest subunit of pol II (Rpb1) following UV-irradiation are significantly suppressed in Elongin A-deficient cells. | Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
Yasukawa T, Kamura T, Kitajima S, Conaway RC, Conaway JW, Aso T., Free PMC Article | 01/21/2010 |
| Results suggest that RNA polymerase II is selectively required for positive transcriptional regulation of a subset of genes in embryonic stem cells. | Defective FESTA/EAF2-mediated transcriptional activation in S-II-deficient embryonic stem cells.
Ito T, Saso K, Arimitsu N, Sekimizu K. | 01/21/2010 |
| Reduction in RNA Pol II association is indicative of interruption in direct interactions of RNA Pol II with PEPCK promoter, with general transcription factors and/or with coregulator molecules contributeing to activation of PEPCK gene. | RNA polymerase II association with the phosphoenolpyruvate carboxykinase (PEPCK) promoter is reduced in vitamin A-deficient mice.
Scribner KB, McGrane MM. | 01/21/2010 |