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Sci Rep. 2011;1:189. doi: 10.1038/srep00189. Epub 2011 Dec 12.

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

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1
Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029 Madrid, Spain.

Abstract

Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle.

PMID:
22355704
PMCID:
PMC3240995
DOI:
10.1038/srep00189
[Indexed for MEDLINE]
Free PMC Article
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