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    CD98hc CD98 heavy chain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40941, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CD98hcprovided by FlyBase
    Official Full Name
    CD98 heavy chainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037533
    Locus tag
    Dmel_CG2791
    See related
    AllianceGenome:FB:FBgn0037533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cd98hc; CG2791; Dmel\CG2791; RE39378p
    Summary
    Predicted to enable catalytic activity. Involved in L-leucine import across plasma membrane. Located in cell cortex. Is expressed in several structures, including extended germ band embryo; germ layer; presumptive embryonic/larval system; ventral midline of embryo; and yolk nucleus. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CD98hc in Genome Data Viewer
    Location:
    84E6-84E6; 3-48 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7974409..7978428, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3800131..3804150, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA : MeU2-C41 Neighboring gene lodestar Neighboring gene doublesex Neighboring gene Seminal fluid protein 84E Neighboring gene Os-C Neighboring gene ELOVL fatty acid elongase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation. Lee J, et al. Autophagy, 2023 Jan. PMID 35506243, Free PMC Article
    2. Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth. Galagovsky D, et al. Cell Rep, 2018 Sep 18. PMID 30231999, Free PMC Article
    3. Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties. Reynolds B, et al. Biochem J, 2009 May 27. PMID 19335336, Free PMC Article
    4. New candidate genes for sex-comb divergence between Drosophila mauritiana and Drosophila simulans. Graze RM, et al. Genetics, 2007 Aug. PMID 17565959, Free PMC Article
    5. dMyc-dependent upregulation of CD98 amino acid transporters is required for Drosophila brain tumor growth. Rebelo AR, et al. Cell Mol Life Sci, 2023 Jan 6. PMID 36609617, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Drosophila CG2791 encodes a functional CD98hc orthologue with conservation in intracellular, transmembrane and extracellular domains.
      Title: Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-leucine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aromatic amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylalanine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    CD98 heavy chain
    Names
    CD98hc-PA
    CD98hc-PB
    CD98hc-PD
    CD98hc-PG
    CG2791-PA
    CG2791-PB
    CG2791-PD
    CG2791-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7974409..7978428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275425.1 → NP_001262354.2  CD98 heavy chain, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGE4, Q8SYR7
      Conserved Domains (1) summary
      cd11329
      Location:117 → 593
      AmyAc_maltase-like; Alpha amylase catalytic domain family found in maltase

    2. NM_001275426.1 → NP_001262355.1  CD98 heavy chain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYR7, Q9VHX9
      Conserved Domains (1) summary
      cd11329
      Location:53 → 529
      AmyAc_maltase-like; Alpha amylase catalytic domain family found in maltase

    3. NM_141495.3 → NP_649752.2  CD98 heavy chain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649752.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYR7, Q9VHX9
      Related
      FBpp0081314
      Conserved Domains (1) summary
      cd11329
      Location:53 → 529
      AmyAc_maltase-like; Alpha amylase catalytic domain family found in maltase

    4. NM_001275427.1 → NP_001262356.1  CD98 heavy chain, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFA6, Q8SYR7
      Conserved Domains (1) summary
      cd11329
      Location:53 → 531
      AmyAc_maltase-like; Alpha amylase catalytic domain family found in maltase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFA6 A0A0B4KFA6
    A0A0B4KGE4 A0A0B4KGE4
    Q8SYR7 Q8SYR7
    Q9VHX9 Q9VHX9

    Gene LinkOut

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