Format

Send to

Choose Destination
J Proteome Res. 2009 Jun;8(6):2667-78. doi: 10.1021/pr800866n.

Mapping organelle proteins and protein complexes in Drosophila melanogaster.

Author information

1
Cambridge Systems Biology Centre, Department of Biochemistry, Tennis Court Road, Cambridge CB2 1QR, United Kingdom.

Abstract

Many proteins within eukaryotic cells are organized spatially and functionally into membrane bound organelles and complexes. A protein's location thus provides information about its function. Here, we apply LOPIT, a mass-spectrometry based technique that simultaneously maps proteins to specific subcellular compartments, to Drosophila embryos. We determine the subcellular distribution of hundreds of proteins, and protein complexes. Our results reveal the potential of LOPIT to provide average snapshots of cells.

PMID:
19317464
DOI:
10.1021/pr800866n
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center