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    IntS6 Integrator 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31496, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IntS6provided by FlyBase
    Official Full Name
    Integrator 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0261383
    Locus tag
    Dmel_CG3125
    See related
    AllianceGenome:FB:FBgn0261383
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3125; Dmel\CG3125; Int6; l(1)G0060
    Summary
    Involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to several human genes including INTS6 (integrator complex subunit 6) and INTS6L (integrator complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See IntS6 in Genome Data Viewer
    Location:
    5B4-5B6; 1-13 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5738663..5747254, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5632696..5641287, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif B Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 27 Neighboring gene uncharacterized protein Neighboring gene Regulator of telomere elongation helicase 1 Neighboring gene uncharacterized protein Neighboring gene lin-52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced nucleotide chemistry and toehold nanotechnology reveals lncRNA spreading on chromatin. Machyna M, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32157249
    2. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
    3. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
    4. The Integrator complex desensitizes cellular response to TGF-β/BMP signaling. Liu S, et al. Cell Rep, 2023 Jan 31. PMID 36641752
    5. Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination. Huang KL, et al. Mol Cell, 2020 Oct 15. PMID 32966759, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events.
      Title: IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator 6
    Names
    CG3125-PA
    CG3125-PB
    CG3125-PC
    CG3125-PD
    CG3125-PE
    IntS6-PA
    IntS6-PB
    IntS6-PC
    IntS6-PD
    IntS6-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5738663..5747254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272332.1 → NP_001259261.1  integrator 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259261.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960F1, Q9W485
      Conserved Domains (2) summary
      cd00198
      Location:4 → 147
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:1196 → 1257
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. NM_001272331.1 → NP_001259260.1  integrator 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960F1, Q9W485
      Conserved Domains (2) summary
      cd00198
      Location:4 → 147
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:1196 → 1257
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    3. NM_132025.3 → NP_572253.2  integrator 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572253.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960F1, Q9W485
      Related
      FBpp0070806
      Conserved Domains (2) summary
      cd00198
      Location:4 → 147
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:1196 → 1257
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    4. NM_001272330.1 → NP_001259259.1  integrator 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960F1, Q9W485
      Conserved Domains (2) summary
      cd00198
      Location:4 → 147
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:1196 → 1257
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    5. NM_167047.2 → NP_727026.1  integrator 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727026.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960F1, Q9W485
      Related
      FBpp0070807
      Conserved Domains (2) summary
      cd00198
      Location:4 → 147
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:1196 → 1257
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W485.2 Q9W485

    Gene LinkOut

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