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    tat-3 Phospholipid-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 176498, updated on 23-Nov-2023

    Summary

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    Gene symbol
    tat-3
    Gene description
    Phospholipid-transporting ATPase
    Primary source
    WormBase:WBGene00012360
    Locus tag
    CELE_W09D10.2
    See related
    AllianceGenome:WB:WBGene00012360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in sterol metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anchor cell; distal tip cell; epithelial cell; pharyngeal-intestinal valve; and pharynx. Orthologous to several human genes including ATP10A (ATPase phospholipid transporting 10A (putative)) and ATP10D (ATPase phospholipid transporting 10D (putative)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (10722148..10730705, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Hexosyltransferase Neighboring gene Protein phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Arf-GAP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans. Lyssenko NN, et al. Biotechniques, 2007 Nov. PMID 18072588
    2. An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases. Lyssenko NN, et al. BMC Dev Biol, 2008 Oct 2. PMID 18831765, Free PMC Article
    3. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Darland-Ransom M, et al. Science, 2008 Apr 25. PMID 18436785
    4. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Züllig S, et al. Curr Biol, 2007 Jun 5. PMID 17540571
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular anatomical entity IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phospholipid-transporting ATPase
    NP_499363.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10722148..10730705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066962.5 → NP_499363.3  Phospholipid-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499363.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18182
      Conserved Domains (5) summary
      TIGR01652
      Location:103 → 1357
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:770 → 848
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:94 → 152
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1107 → 1356
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1075 → 1107
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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