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    PRKDC protein kinase, DNA-activated, catalytic subunit [ Bos taurus (cattle) ]

    Gene ID: 512740, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PRKDCprovided by VGNC
    Official Full Name
    protein kinase, DNA-activated, catalytic subunitprovided by VGNC
    Primary source
    VGNC:VGNC:33339
    See related
    BGD:BT18179; Ensembl:ENSBTAG00000017019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    86
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (19424288..19551057, complement)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene scaffold protein involved in DNA repair Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene H3 histone, family 3C Neighboring gene nucleolar RNA helicase 2-like Neighboring gene minichromosome maintenance complex component 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Application of disease-associated differentially expressed genes--mining for functional candidate genes for mastitis resistance in cattle. Schwerin M, et al. Genet Sel Evol, 2003. PMID 12927078, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-dependent protein kinase catalytic subunit
    Names
    protein kinase catalytic subunit (DNA-dependent protein kinase)
    protein kinase, DNA-activated, catalytic polypeptide
    NP_001243488.2
    XP_010810253.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256559.2 → NP_001243488.2  DNA-dependent protein kinase catalytic subunit

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000014
      UniProtKB/TrEMBL
      E1BLB6
      Conserved Domains (5) summary
      cd05172
      Location:3715 → 4011
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:3029 → 3466
      FAT; FAT domain
      pfam02260
      Location:4094 → 4124
      FATC; FATC domain
      pfam08163
      Location:1816 → 2203
      NUC194; NUC194 domain
      cl26692
      Location:3498 → 4011
      FRB_dom; FKBP12-rapamycin binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19424288..19551057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010811951.4 → XP_010810253.2  DNA-dependent protein kinase catalytic subunit isoform X1

      Related
      ENSBTAP00000022631.7, ENSBTAT00000022631.7
      Conserved Domains (5) summary
      cd05172
      Location:3715 → 4011
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:3029 → 3466
      FAT; FAT domain
      pfam02260
      Location:4094 → 4124
      FATC; FATC domain
      pfam08163
      Location:1816 → 2203
      NUC194; NUC194 domain
      cl26692
      Location:3498 → 4011
      FRB_dom; FKBP12-rapamycin binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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