Format

Send to:

Choose Destination

Prkdc protein kinase, DNA activated, catalytic polypeptide [ Mus musculus (house mouse) ]

Gene ID: 19090, updated on 9-Oct-2018

Summary

Official Symbol
Prkdcprovided by MGI
Official Full Name
protein kinase, DNA activated, catalytic polypeptideprovided by MGI
Primary source
MGI:MGI:104779
See related
Ensembl:ENSMUSG00000022672 Vega:OTTMUSG00000043440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; AI326420; AU019811; DNA-PKcs
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.5), frontal lobe adult (RPKM 1.2) and 27 other tissues See more
Orthologs

Genomic context

See Prkdc in Genome Data Viewer
Location:
16 10.09 cM; 16 A2
Exon count:
88
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (15637443..15842252)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (15637959..15842332)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene 7748 Neighboring gene minichromosome maintenance complex component 4 Neighboring gene mitotic spindle organizing protein 2 Neighboring gene predicted gene, 41425 Neighboring gene 60S ribosomal protein L30-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
V(D)J recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin V(D)J recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immune system process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
pro-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in mitotic G1 DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
spleen development ISO
Inferred from Sequence Orthology
more info
 
telomere capping ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
DNA-dependent protein kinase-DNA ligase 4 complex ISO
Inferred from Sequence Orthology
more info
 
nonhomologous end joining complex ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-dependent protein kinase catalytic subunit
Names
DNA-PK catalytic subunit
doxorubicin nephropathy
severe combined immunodeficiency
NP_035289.2
XP_006521924.1
XP_011244143.1
XP_011244144.1
XP_017172381.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011159.2NP_035289.2  DNA-dependent protein kinase catalytic subunit

    See identical proteins and their annotated locations for NP_035289.2

    Status: VALIDATED

    Source sequence(s)
    AB007544, AB011543, AK084827, AK137732, AU019811, CT030649
    Consensus CDS
    CCDS27978.1
    UniProtKB/Swiss-Prot
    P97313
    Related
    ENSMUSP00000023352.7, OTTMUSP00000063630, ENSMUST00000023352.8, OTTMUST00000113952
    Conserved Domains (5) summary
    cd05172
    Location:37194014
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:30243470
    FAT; FAT domain
    pfam02260
    Location:40974128
    FATC; FATC domain
    pfam08163
    Location:18122198
    NUC194; NUC194 domain
    pfam11728
    Location:17661822
    ArAE_1_C; Putative aromatic acid exporter C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    15637443..15842252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521861.3XP_006521924.1  DNA-dependent protein kinase catalytic subunit isoform X1

    Conserved Domains (3) summary
    pfam02259
    Location:30243301
    FAT; FAT domain
    pfam08163
    Location:18122198
    NUC194; NUC194 domain
    pfam11728
    Location:17661822
    ArAE_1_C; Putative aromatic acid exporter C-terminal domain
  2. XM_017316892.1XP_017172381.1  DNA-dependent protein kinase catalytic subunit isoform X2

  3. XM_011245842.2XP_011244144.1  DNA-dependent protein kinase catalytic subunit isoform X4

    Conserved Domains (2) summary
    pfam08163
    Location:18122198
    NUC194; NUC194 domain
    pfam11728
    Location:17661822
    ArAE_1_C; Putative aromatic acid exporter C-terminal domain
  4. XM_011245841.2XP_011244143.1  DNA-dependent protein kinase catalytic subunit isoform X3

    Conserved Domains (5) summary
    cd05172
    Location:20152310
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:13201766
    FAT; FAT domain
    pfam02260
    Location:23932424
    FATC; FATC domain
    pfam08163
    Location:108494
    NUC194; NUC194 domain
    pfam11728
    Location:62118
    ArAE_1_C; Putative aromatic acid exporter C-terminal domain
Support Center