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    CRHR1 corticotropin releasing hormone receptor 1 [ Ovis aries (sheep) ]

    Gene ID: 443025, updated on 5-Mar-2024

    Summary

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    Gene symbol
    CRHR1
    Gene description
    corticotropin releasing hormone receptor 1
    See related
    EnsemblRapid:ENSOARG00020024443
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    CRF1
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (45529956..45589409)

    Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 2 Neighboring gene large ribosomal subunit protein uL22-like Neighboring gene signal peptide peptidase like 2C Neighboring gene microtubule associated protein tau Neighboring gene uncharacterized LOC132657430

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant. Myers DA, et al. Mol Cell Endocrinol, 1998 Sep 25. PMID 9863624

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotrophin-releasing factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotropin-releasing hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotropin-releasing hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    corticotropin-releasing factor receptor 1
    Names
    CRF-R-1
    CRF-R1
    CRFR-1
    CRH-R-1
    CRH-R1
    corticotropin releasing factor receptor type 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009727.1 → NP_001009727.1  corticotropin-releasing factor receptor 1 precursor

      See identical proteins and their annotated locations for NP_001009727.1

      Status: PROVISIONAL

      Source sequence(s)
      AF054582
      UniProtKB/Swiss-Prot
      O62772
      UniProtKB/TrEMBL
      W5PNE7
      Related
      ENSOARP00020032218.1, ENSOART00020038882.2
      Conserved Domains (2) summary
      smart00008
      Location:40 → 111
      HormR; Domain present in hormone receptors
      pfam00002
      Location:116 → 359
      7tm_2; 7 transmembrane receptor (Secretin family)

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      45529956..45589409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027973948.3 → XP_027829749.1  corticotropin-releasing factor receptor 1 isoform X1

      UniProtKB/TrEMBL
      W5PNE7

    2. XM_027973949.3 → XP_027829750.1  corticotropin-releasing factor receptor 1 isoform X2

      UniProtKB/TrEMBL
      W5PNE7
      Related
      ENSOARP00020032211.1, ENSOART00020038873.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62772.1 GenPept UniProtKB/Swiss-Prot:O62772

    Gene LinkOut

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