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Crhr1 corticotropin releasing hormone receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 12921, updated on 2-Nov-2024

Summary

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Official Symbol
Crhr1provided by MGI
Official Full Name
corticotropin releasing hormone receptor 1provided by MGI
Primary source
MGI:MGI:88498
See related
Ensembl:ENSMUSG00000018634 AllianceGenome:MGI:88498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crhr; CRF1R; CRFR1; CRF-R1alpha
Summary
The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in cerebellum adult (RPKM 7.7), frontal lobe adult (RPKM 4.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Crhr1 in Genome Data Viewer
Location:
11 E1; 11 67.77 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104021289..104066349)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104130463..104175523)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35420 Neighboring gene predicted gene, 51921 Neighboring gene predicted gene, 42092 Neighboring gene predicted gene, 35469 Neighboring gene STARR-seq mESC enhancer starr_30874 Neighboring gene signal peptide peptidase 2C Neighboring gene predicted gene, 53648 Neighboring gene microtubule-associated protein tau

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Wang XD, et al. Neurobiol Dis, 2011 Jun. PMID 21296667, Free PMC Article
  2. The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling. Sparta DR, et al. Alcohol Clin Exp Res, 2009 Jan. PMID 18945225, Free PMC Article
  3. Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing factor receptor 1 (CRFR1). Assil-Kishawi I, et al. J Biol Chem, 2008 Dec 19. PMID 18955489, Free PMC Article
  4. Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems. Sandi C, et al. Eur J Neurosci, 2008 Nov. PMID 18973598
  5. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. Kash TL, et al. J Neurosci, 2008 Dec 17. PMID 19091975, Free PMC Article

See all (223) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression.
    Title: Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.
  2. Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice.
    Title: Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice.
  3. The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.
    Title: The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.
  4. Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making.
    Title: Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making.
  5. The CRF1 receptor mediates social behavior deficits induced by opiate withdrawal.
    Title: The CRF(1) receptor mediates social behavior deficits induced by opiate withdrawal.
  6. Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period.
    Title: Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period.
  7. Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5.
    Title: Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5.
  8. Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure.
    Title: Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure.
  9. Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF1 receptors in the medial prefrontal cortex and BNST.
    Title: Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF(1) receptors in the medial prefrontal cortex and BNST.
  10. Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke.
    Title: Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA(2) phosphorylation in experimental ischemic stroke.
Submit: New GeneRIF Correction See all GeneRIFs (126)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (13)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124237, MGC124240

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables corticotrophin-releasing factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables corticotrophin-releasing factor receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables corticotrophin-releasing factor receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables corticotropin-releasing hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables corticotropin-releasing hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables corticotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables corticotropin-releasing hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adrenal gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to pain ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to corticotropin-releasing hormone stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in corticotropin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within exploration behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within general adaptation syndrome, behavioral process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of corticosterone secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
corticotropin-releasing factor receptor 1
Names
CRF 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313928.1 → NP_001300857.1  corticotropin-releasing factor receptor 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK144430, AK158806, BQ174858, BY278495, CJ143058, CJ155572, FJ668671
    UniProtKB/TrEMBL
    K9J9G1
    Conserved Domains (2) summary
    pfam00002
    Location:76 → 319
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl02422
    Location:28 → 71
    HRM; Hormone receptor domain

  2. NM_001313929.1 → NP_001300858.1  corticotropin-releasing factor receptor 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK144430, AK158806, BC105673, BQ174858, BY278495, CJ143058, CJ155572
    UniProtKB/TrEMBL
    Q0VGH2
    Conserved Domains (2) summary
    cd14964
    Location:23 → 43
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 175
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001430903.1 → NP_001417832.1  corticotropin-releasing factor receptor 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL596383, AL603829
    UniProtKB/TrEMBL
    Q0VGH2

  4. NM_007762.5 → NP_031788.1  corticotropin-releasing factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK144430, AK158806, BQ174858, CJ143058, CJ155572
    Consensus CDS
    CCDS25526.1
    UniProtKB/Swiss-Prot
    P35347
    UniProtKB/TrEMBL
    Q3ZAT0
    Related
    ENSMUSP00000091455.5, ENSMUST00000093925.5
    Conserved Domains (2) summary
    smart00008
    Location:40 → 111
    HormR; Domain present in hormone receptors
    pfam00002
    Location:116 → 359
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    104021289..104066349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156275.1 → XP_036012168.1  corticotropin-releasing factor receptor 1 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:23 → 43
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 175
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_036156274.1 → XP_036012167.1  corticotropin-releasing factor receptor 1 isoform X1

    Conserved Domains (1) summary
    cd15445
    Location:75 → 339
    7tmB1_CRF-R1; corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors

  3. XM_017314246.1 → XP_017169735.1  corticotropin-releasing factor receptor 1 isoform X1

    Conserved Domains (1) summary
    cd15445
    Location:75 → 339
    7tmB1_CRF-R1; corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors

RNA

  1. XR_001779869.2 RNA Sequence

  2. XR_001779870.2 RNA Sequence

  3. XR_001779871.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35347.1 GenPept UniProtKB/Swiss-Prot:P35347

Gene LinkOut

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